N-DESMETHYL ROSIGLITAZONE
- Product Name
- N-DESMETHYL ROSIGLITAZONE
- CAS No.
- 257892-31-2
- Chemical Name
- N-DESMETHYL ROSIGLITAZONE
- Synonyms
- SB 237216;N-DESMETHYL ROSIGLITAZONE;N-Desmethyl Rosiglitazone Solution, 100ppm;5-[[4-[2-(2-pyridinylamino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[4-[2-(2-pyridinylamino)ethoxy]phenyl]methyl]-;N-Desmethyl RosiglitazoneQ: What is N-Desmethyl Rosiglitazone Q: What is the CAS Number of N-Desmethyl Rosiglitazone Q: What is the storage condition of N-Desmethyl Rosiglitazone Q: What are the applications of N-Desmethyl Rosiglitazone
- CBNumber
- CB8433330
- Molecular Formula
- C17H17N3O3S
- Formula Weight
- 343.4
- MOL File
- 257892-31-2.mol
N-DESMETHYL ROSIGLITAZONE Property
- Melting point:
- 177-179°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Pale Beige
N-Bromosuccinimide Price
- Product number
- 22103
- Product name
- N-desmethyl Rosiglitazone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $104
- Updated
- 2024/03/01
- Product number
- 22103
- Product name
- N-desmethyl Rosiglitazone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $395
- Updated
- 2024/03/01
- Product number
- 22103
- Product name
- N-desmethyl Rosiglitazone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $656
- Updated
- 2024/03/01
- Product number
- D3218-50
- Product name
- N-Desmethyl Rosiglitazone |
- Packaging
- 1mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- D292165
- Product name
- N-DesmethylRosiglitazone
- Packaging
- 2.5mg
- Price
- $155
- Updated
- 2021/12/16
N-DESMETHYL ROSIGLITAZONE Chemical Properties,Usage,Production
Description
N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Item Nos. 71740 | 71742 | 11884), a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.
Chemical Properties
White Solid
Uses
A metabolite of Rosiglitazone.
Definition
ChEBI: N-desmethylrosiglitazone is an aromatic ether.
References
[1] J M LEHMANN. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).[J]. The Journal of Biological Chemistry, 1995, 270 22: 12953-12956. DOI: 10.1074/jbc.270.22.12953
[2] KWON-BOK KIM . Simultaneous quantification of rosiglitazone and its two major metabolites, N-desmethyl and p-hydroxy rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study[J]. Journal of Chromatography B, 2009, 877 20: Pages 1951-1956. DOI: 10.1016/j.jchromb.2009.05.001
N-DESMETHYL ROSIGLITAZONE Preparation Products And Raw materials
Raw materials
Preparation Products
N-DESMETHYL ROSIGLITAZONE Suppliers
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