ChemicalBook > CAS DataBase List > 5-Chloro-2,3-difluoropyridine

5-Chloro-2,3-difluoropyridine

Product Name
5-Chloro-2,3-difluoropyridine
CAS No.
89402-43-7
Chemical Name
5-Chloro-2,3-difluoropyridine
Synonyms
2,3-DIFLUORO-5-CHLOROPYRIDINE;2,3-Difulor-5-Chloropyridine;2,3-Difluoro-5-Chloro;2,3-DIFLUORO-5-CHLOROPYRIDIN;2,3-Difuoro-5-chloropyridine;2,3-fluoro-5-chloro pyridine;5-CHLORO-2,3-DIFLUOROPYRIDINE;5-Chloro-2,3 difluro pyridine;5-Chloro-2,3-Difluoropyridine96%;5-Chloro-2,3-difluoropyridine98%
CBNumber
CB8438870
Molecular Formula
C5H2ClF2N
Formula Weight
149.53
MOL File
89402-43-7.mol
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5-Chloro-2,3-difluoropyridine Property

Melting point:
47-49 C
Boiling point:
135°C
Density 
1.442 g/mL at 25 °C
refractive index 
1.4738
Flash point:
135°C
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
-5.14±0.20(Predicted)
form 
Oil
color 
Clear Colourless
BRN 
4177319
InChI
InChI=1S/C5H2ClF2N/c6-3-1-4(7)5(8)9-2-3/h1-2H
InChIKey
PERMDYZFNQIKBL-UHFFFAOYSA-N
SMILES
C1(F)=NC=C(Cl)C=C1F
CAS DataBase Reference
89402-43-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-52/53-10-36/37/38-20/21/22
Safety Statements 
23-36-61-26
RIDADR 
2810
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HazardClass 
3
PackingGroup 
III
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
720208
Product name
2,3-Difluoro-5-chloropyridine
Purity
95%
Packaging
5g
Price
$17.1
Updated
2023/06/20
TCI Chemical
Product number
C2113
Product name
5-Chloro-2,3-difluoropyridine
Purity
>93.0%(GC)
Packaging
5g
Price
$19
Updated
2025/07/31
TCI Chemical
Product number
C2113
Product name
5-Chloro-2,3-difluoropyridine
Purity
>93.0%(GC)
Packaging
25g
Price
$60
Updated
2025/07/31
TRC
Product number
C365385
Product name
5-Chloro-2,3-difluoropyridine
Packaging
25g
Price
$140
Updated
2021/12/16
TRC
Product number
C365385
Product name
5-Chloro-2,3-difluoropyridine
Packaging
250g
Price
$1110
Updated
2021/12/16
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5-Chloro-2,3-difluoropyridine Chemical Properties,Usage,Production

Uses

5-Chloro-2,3-difluoropyridine is a 2,3,5-trihalopyridine used in the preparation of the herbicides and pesticides such as chodinafop-propargyl.

Synthesis

16063-70-0

89402-43-7

General procedure for the synthesis of 2,3-difluoro-5-chloropyridine from 2,3,5-trichloropyridine: First, 400 g of cyclobutanesulfone and 400 g of dimethylsulfoxide were added to a 1000 mL flask, and dehydrated to a moisture content of less than 0.05% at 200 °C under 0.05 MPa (negative pressure). Subsequently, 96 g (1.66 mol) of potassium fluoride, 120 g (0.67 mol) of 2,3,5-trichloropyridine, 2 g of 18-crown ether, and 3 g of potassium carbonate were added to the reaction flask at 120 °C and heated to 200 °C for about 3 hours. After completion of the reaction, the product was collected to give 95 g (0.51 mol) of 2,3-difluoro-5-chloropyridine in 90% yield. The purity of the product was 96.8% as determined by gas chromatography.

References

[1] Patent: CN106008329, 2016, A. Location in patent: Paragraph 0008; 0009
[2] Synthetic Communications, 2004, vol. 34, # 23, p. 4301 - 4311
[3] Patent: US33478, 1990, E1
[4] Patent: US4565568, 1986, A
[5] Patent: US4678509, 1987, A

5-Chloro-2,3-difluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Chloro-2,3-difluoropyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Chloro-2,3-difluoropyridine 89402-43-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
5-Chloro-2,3-difluoropyridine 89402-43-7
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-24
Hubei Lidu New Material Technology Co., Ltd
Product
5-Chloro-2,3-difluoropyridine 89402-43-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2024-10-30

89402-43-7, 5-Chloro-2,3-difluoropyridineRelated Search:

2,3-Difluoropyridine 2-chloro-6-trichloromethylpyridine Clopidol 2-Chloro-5-chloromethylpyridine 2,3,5,6-Tetrachloropyridine 2-Chloropyridine-N-oxide 1-Chloro-1,1-difluoroethane 3-Chloro-2,4,5,6-tetrafluoropyridine 3-CHLORO-2,5,6-TRIFLUOROPYRIDINE 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE 5-Chloro-2,3-difluoro-4-iodopyridine 5-CHLORO-2,3,4-TRIFLUOROPYRIDINE 5-Chloro-2,3-difluoropyridine 2,5-DIFLUORO-4-CHLOROPYRIDINE 1-(3-chloro-2,5,6-trifluoropyridin-4-yl)hydrazine 3-CHLORO-2,5,6-TRIFLUORO-4-PYRIDINOL

  • 2,3-DIFLUORO-5-CHLOROPYRIDIN
  • 2,3-DIFLUORO-5-CHLOROPYRIDINE
  • 5-CHLORO-2,3-DIFLUOROPYRIDINE
  • 5-Chloro-2,3-Difluoropyridine96%
  • 2,3-Difluoro-5-Chloro
  • intermediate for Clodinafop-propargyl
  • 2,3-Difulor-5-Chloropyridine
  • 5-Chloro-2,3-difluoropyridine 98%
  • 5-Chloro-2,3-difluoropyridine98%
  • 5-Chloro-2,3 difluro pyridine
  • 2,3-Difuoro-5-chloropyridine
  • 2,3-fluoro-5-chloro pyridine
  • 5-Chloro-2,3-difluoropyridine,97%
  • 5-Chloro-2,3-difluoropyridine &gt
  • Pyridine, 5-chloro-2,3-difluoro-
  • 5-Chloro-2,3-difluoropyridine ISO 9001：2015 REACH
  • 2,3-Difluoro-5-chloro pyridine (CDFP)
  • 2,3 Difluoro 5-chloro pyridine, 97%+
  • high quality 2,3-Difluoro-5-chloropyridine
  • 5-Chloro-2,3-difluoropyridine（CDFP）
  • 89402-43-7
  • 89042-43-7
  • 84902-43-7
  • C5H2CIF2N
  • C5H2NClF2
  • C5H2ClF2N
  • Fluorine series
  • alkyl Fluorine| alkyl chloride
  • Chloropyridines
  • Fluoropyridines
  • Halopyridines
  • blocks
  • FluoroCompounds
  • Pyridines
  • Pyridine
  • bc0001
  • 89402-43-7
  • OLED