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Famoxadone

Product Name
Famoxadone
CAS No.
131807-57-3
Chemical Name
Famoxadone
Synonyms
JE 874;Famoxate;Famoxadon;CCharisma;IN-JE 874;DPX-JE 874;FAMOXADONE;FaMoxadone solutio;famoxadone solution;C13399000 Famoxadone
CBNumber
CB8439206
Molecular Formula
C22H18N2O4
Formula Weight
374.39
MOL File
131807-57-3.mol
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Famoxadone Property

Melting point:
140.3～141.8℃
Boiling point:
491.3±55.0 °C(Predicted)
Density 
1.327±0.06 g/cm3(Predicted)
vapor pressure 
6.4 x 10-7 Pa (20 °C)
Flash point:
2 °C
storage temp. 
0-6°C
solubility 
DMSO: 100 mg/mL (267.10 mM)
Water Solubility 
0.243 mg-1 (pH 5), 0.011 mg l-1 (pH 7) at 20 °C
pka
0.63±0.40(Predicted)
form 
Solid:particulate/powder
color 
White to yellow
LogP
4.65-5.08 at 20℃ and pH4-7
Surface tension
73mN/m at 90μg/L and 20.4℃
EPA Substance Registry System
Famoxadone (131807-57-3)
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Safety

Hazard Codes 
Xn,N,F
Risk Statements 
48/22-50/53-36-20/21/22-11
Safety Statements 
46-60-61-36-26-16-36/37
RIDADR 
UN1648 3/PG 2
WGK Germany 
2
Hazardous Substances Data
131807-57-3(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Joshi, Sternberg)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33495
Product name
Famoxadone solution
Purity
100?μg/mL in acetonitrile, PESTANAL?, analytical standard
Packaging
2ML
Price
$86.2
Updated
2024/03/01
TRC
Product number
F102300
Product name
Famoxadone
Packaging
1g
Price
$145
Updated
2021/12/16
TRC
Product number
F102300
Product name
Famoxadone
Packaging
10g
Price
$305
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
51328
Product name
Famoxadone
Packaging
1g
Price
$620
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
51328
Product name
Famoxadone
Packaging
50g
Price
$875
Updated
2021/12/16
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Famoxadone Chemical Properties,Usage,Production

Description

Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.

Chemical Properties

Brown Solid

Uses

Famoxadone provides preventive control of a broad spectrum of fungal pathogens such as Plasmopara viticola (grape downy mildew), Phytophthora infestans (potato/ tomato late blight), Pseudoperonospora cubensis (cucumber downy mildew), Septoria tritici (wheat leaf blotch), S. nodorum (wheat glume blotch) and Alternaria solani (potato/tomato early blight).

Uses

Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.

Uses

Agricultural fungicide.

Definition

ChEBI: 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione is a member of the class of oxazolidinones that is 1,3-oxazolidine-2,4-dione in which the hydrogen attached to the nitrogen is substituted by a phenylamino group and the hydrogens at position 5 are substituted by methyl and 4-phenoxyphenyl groups. It is an aromatic ether, a carbohydrazide and an oxazolidinone.

Agricultural Uses

Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.

Trade name

DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®

Pharmacology

Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).

Metabolic pathway

Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.

Degradation

Famoxadone is relatively stable to hydrolytic degradation under dark conditions in pH 5 buffer solution (DT50 41 days) (Jernberg et al., 1998a). It was hydrolysed rapidly at pH 7 and pH 9 at 25 °C (DT50 values 2 days and <2 hours, respectively). No sigruficant sunlight-induced degradation was observed at pH 7. Hydrolytic degradation was catalysed in acidic conditions (pH 5) under natural sunlight (DT50 4.6 days in contrast to 41 days at pH 7). Primary hydrolytic degradation reactions include the opening of the oxazolidinedione ring [to yieldα-hydroxy-α-methyl-4-phenoxyphenylacetic acid 2-phenylhydrazide (2) and 1-carboxy-1-(4-phenoxy-phenyl) ethyl-2-phenylhydrazinecarboxylic acid (3)], and the cleavage of the oxazolidine-aminophenyl linkage to yield various products from both the phenoxyphenyl moiety [ 1-(4-phenoxyphenyl)ethanone (4) and α-hydroxy- α-methyl-4-phenoxyphenylacetiac acid (5)] and the aminophenyl moiety [small amounts of phenol (6), catechol (7) and benzene (8) via the proposed 2-phenylhydrazinecarboxylic acid intermediate (9)] (see Scheme 1).

Toxicity evaluation

Famoxadone has an acute oral LD50 > 5,000 mg/kg and an acute percutaneous LD50 > 2,000 mg/kg in rats. It is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows very little soil degradation, is nonmobile, and has a good ecotoxicological profile.

Famoxadone Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 4'-Phenoxyacetophenone

Preparation Products

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Famoxadone Suppliers

Canada 1 China 144 France 2 Germany 1 India 2 Japan 2 South Korea 1 Switzerland 1 United Kingdom 3 United States 15 Global 172
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
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--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
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--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
AccuStandard Inc
Tel
--
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--
Email
info@bester.nl
Country
United States
ProdList
5300
Advantage
76
Waterstone Technology, LLC
Tel
--
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--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
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30
ChemService Inc.
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--
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Country
United States
ProdList
6379
Advantage
68
DuPont Specialty Colorants & Additives
Tel
--
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Country
United States
ProdList
1186
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87
2A PharmaChem USA
Tel
--
Fax
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Email
sales@2apharmachem.com
Country
United States
ProdList
6137
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39
3B Scientific Corporation
Tel
--
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Email
sales@3bsc.com
Country
United States
ProdList
6718
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47
Crescent Chemical Co., Inc.
Tel
--
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sales@creschem.com
Country
United States
ProdList
4597
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68
American Custom Chemicals Corporation
Tel
--
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Email
sales@acccorporation.com
Country
United States
ProdList
6820
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51
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View Lastest Price from Famoxadone manufacturers

qingdao trust agri chemical co.,ltd
Product
Famoxadone 131807-57-3
Price
US $0.00/KG
Min. Order
100KG
Purity
98
Supply Ability
200TONS
Release date
2024-07-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
Famoxadone 131807-57-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Famoxadone 131807-57-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

131807-57-3, FamoxadoneRelated Search:

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  • Semicarbacide Hydrochloride, Vetranal
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  • famoxadone (bsi, pa iso)
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  • famoxadone 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione
  • 3-pheny-lamino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione
  • CCharisma
  • DPX-JE 874
  • IN-JE 874
  • JE 874
  • FaMoxadone solutio
  • 2,4-Oxazolidinedione,5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-
  • FAMOXADONE
  • 3-ANILINO-5-METHYL-5-(4-PHENOXYPHENYL)OXAZOLIDINE-2,4-DIONE
  • Famoxadone Solution, 1000ppm
  • FamoxadoneSolution,100mg/L,1ml
  • Famoxadone Reference Material
  • Famoxadon@1000 μg/mL in Acetonitrile
  • Famoxadon @100 μg/mL in Acetonitrile
  • Famoxadone Solution in Methanol, 100μg/mL
  • Fensulfothion Impurity 8
  • Famoxadone Solution in Methanol
  • C13399000 Famoxadone
  • L13399000CY FamoxadonE10μg/mLin Cyclohexane
  • Famoxadone in Acetonitrile
  • 131807-57-3
  • 13180-57-3
  • API
  • agrochemical
  • Fungicide