2-Bromoisobutyryl Bromide Property

Boiling point:

162-164 °C(lit.)

Density 

1.86 g/mL at 20 °C

refractive index 

n20/D 1.507(lit.)

Flash point:

>110°C

storage temp. 

Store below +30°C.

solubility 

Miscible with acetone and carbon disulfide.

form 

Liquid

Specific Gravity

1.860 (20/4℃)

color 

Clear light yellow to yellow

Water Solubility 

reacts

Sensitive 

Moisture Sensitive

BRN 

1746128

Stability:

Stable, but may react with moisture. Incompatible with water, strong oxidizing agents, strong bases.

CAS DataBase Reference

20769-85-1(CAS DataBase Reference)

NIST Chemistry Reference

Propanoyl bromide, 2-bromo-2-methyl-(20769-85-1)

EPA Substance Registry System

Propanoyl bromide, 2-bromo-2-methyl- (20769-85-1)

Safety

Hazard Codes 

C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29159080

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

2-Bromoisobutyryl Bromide Chemical Properties,Usage,Production

Description

2-Bromoisobutyryl Bromide is a kind of bromide being useful in the chemical industry. It is used as an intermediate for the synthesis of pharmaceuticals, agrochemicals, dyes and other organic chemicals1. It can be used as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide; to form an N-protected halodienamide which provided fourand five-membered lactams in the presence of copper (I) and a tertiary amine; in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone dio and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface2,3. As a initiator precursor, it can also be used for surface modification of Ethylene-vinyl alcohol (EVOH) copolymer films to grow surface-grafted poly-(acrylamide) chains.

Sources

1. http://www.chemicalland21.com/specialtychem/finechem/2-BROMOISOBUTYRYL%20BROMIDE.htm
2. https://www.alfa.com/zh-cn/catalog/B24249/
3. https://www.sigmaaldrich.com/catalog/product/aldrich/252271?lang=en&region=US
4. https://pubs.acs.org/doi/abs/10.1021/bk-2003-0854.ch025

Chemical Properties

colourless liquid

Uses

2-Bromoisobutyryl bromide is used to prepare N-protected halodienamide, which provides four- and five-membered lactams in the presence of copper(I) and a tertiary amine. Further, it is used as atom transfer radical polymerization(ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide. It is also used in preparation of polycaprolactone macroinitiators through reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface.

Uses

α-Bromoisobutyryl bromide has been used:

• as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide
• to form an N-protected halodienamide which provided four- and five-membered lactams in the presence of copper (I) and a tertiary amine
• in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface