2-Bromo-2-methylpropionic acid
- Product Name
- 2-Bromo-2-methylpropionic acid
- CAS No.
- 2052-01-9
- Chemical Name
- 2-Bromo-2-methylpropionic acid
- Synonyms
- 2-Bromo-2-methylpropanoic acid;2-BROMOISOBUTYRIC ACID;Isobromobutyric acid;A-BROMOISOBUTYRIC ACID;2-bromo-2-methyl-Propanoicacid;2-broMo isobutyrate;α-Bromoisobutyric acid;α-Bromoisobutyric acid;pha-Bromoisobutyric acid;ALPHA-BROMOISOBUTYRIC ACID
- CBNumber
- CB0433637
- Molecular Formula
- C4H7BrO2
- Formula Weight
- 167
- MOL File
- 2052-01-9.mol
2-Bromo-2-methylpropionic acid Property
- Melting point:
- 44-47 °C(lit.)
- Boiling point:
- 198-200 °C(lit.)
- Density
- 1.43 g/cm3
- refractive index
- 1.4570 (estimate)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- soluble in Chloroform, Methanol
- pka
- 2.91±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to slightly yellow
- Water Solubility
- Soluble in alcohol and ether. Slightly soluble in water.
- Merck
- 14,1421
- BRN
- 1745543
- Stability:
- Stable. Incompatible with strong oxidizing agents, strong bases.
- CAS DataBase Reference
- 2052-01-9(CAS DataBase Reference)
- NIST Chemistry Reference
- «alpha»-Bromoisobutyric acid(2052-01-9)
- EPA Substance Registry System
- Propanoic acid, 2-bromo-2-methyl- (2052-01-9)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-25
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 13
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29156000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 306851
- Product name
- 2-Bromo-2-methylpropionic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $53.6
- Updated
- 2025/07/31
- Product number
- 306851
- Product name
- 2-Bromo-2-methylpropionic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- B0605
- Product name
- 2-Bromoisobutyric Acid
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B0605
- Product name
- 2-Bromoisobutyric Acid
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- B0605
- Product name
- 2-Bromoisobutyric Acid
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $267
- Updated
- 2025/07/31
2-Bromo-2-methylpropionic acid Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
2-Bromoisobutyric acid is used in the synthesis of dextran macroinitiator for atom transfer radical polymerization (ATRP) by partial esterification of hydroxyl group of the polysaccharide. The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
Uses
2-Bromo-2-methylpropionic acid is used in the Herceptin functionalization of polyhedral oligomeric silsesquioxane-conjugated oligomers-silica /iron oxide nanoparticles for tumor cell sorting.
General Description
The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
Synthesis
79-31-2
630-51-3
2052-01-9
The general procedure for the synthesis of 2,2,3,3-tetramethylbutanedioic acid and 2-bromo isobutyric acid using isobutyric acid as starting material was as follows: 0.005 moles of carboxylic acid 1 was dissolved in 20 mL of anhydrous THF under argon protection, followed by the slow dropwise addition of this solution to a pre-cooled 0.01 moles of LDA (lithium diisopropylammonium) in 30 mL of anhydrous THF. The reaction mixture was gradually warmed to 35-40°C and stirred at this temperature for 30-40 minutes. Upon completion of the reaction, the mixture was cooled to 20-25°C, followed by addition of 0.005 moles of a solution of N,N-diethyl-N-halogenated amine 3 in 20 mL of anhydrous THF. The resulting mixture was continued to be stirred for 2 hours. At the end of the reaction, it was diluted with 30 ml of distilled water and the pH was adjusted with HCl to 1. The reaction product was extracted with ether (3 x 30 ml) and the combined organic phases were dried over anhydrous Na2SO4 and subsequently concentrated. Removal of the ether gave a mixture of dicarboxylic acids 8a-8c and α-halocarboxylic acids 9a-9f. The structures of the products were confirmed by 1H NMR and 13C NMR spectroscopic analyses and the data were in agreement with those reported in the literature [2,3].
References
[1] Russian Journal of General Chemistry, 2016, vol. 86, # 11, p. 2469 - 2472
[2] Zh. Obshch. Khim., 2016, vol. 86, # 11, p. 1826 - 1829,4
2-Bromo-2-methylpropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-2-methylpropionic acid manufacturers
- Product
- 2-Bromo-2-methylpropionic acid 2052-01-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10
- Product
- 2-Bromo-2-methylpropionic acid 2052-01-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- 2-Bromoisobutyric acid 2052-01-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-12