ChemicalBook > CAS DataBase List > KN-62

KN-62

Product Name
KN-62
CAS No.
127191-97-3
Chemical Name
KN-62
Synonyms
KN-2;N 62;KN-62;CS-756;KN-62 97%;KN-62,97%;KN 62;KN-2;KN-62, 99+%;KN 62; KN62;KN-62, >=98%
CBNumber
CB8443368
Molecular Formula
C38H35N5O6S2
Formula Weight
721.84
MOL File
127191-97-3.mol
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KN-62 Property

Melting point:
92-94°C
Boiling point:
964.7±75.0 °C(Predicted)
Density 
1.388
storage temp. 
-20°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
form 
solid
pka
4.07±0.13(Predicted)
color 
white
biological source
synthetic (organic)
CAS DataBase Reference
127191-97-3(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I2142
Product name
KN-62
Purity
≥95%, powder
Packaging
.5mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
422706
Product name
KN-62
Packaging
1mg
Price
$181
Updated
2023/01/07
Alfa Aesar
Product number
J62444
Product name
KN-62
Packaging
1mg
Price
$103.65
Updated
2024/03/01
Alfa Aesar
Product number
J62444
Product name
KN-62
Packaging
10mg
Price
$604.65
Updated
2024/03/01
Cayman Chemical
Product number
13318
Product name
KN-62
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
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KN-62 Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II

Uses

selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,

Uses

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Definition

ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.

General Description

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biological Activity

Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

storage

-20°C (desiccate)

KN-62 Preparation Products And Raw materials

Raw materials

Preparation Products

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KN-62 Suppliers

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View Lastest Price from KN-62 manufacturers

Career Henan Chemical Co
Product
KN-62 127191-97-3
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-29

127191-97-3, KN-62Related Search:

N-Aminoethylpiperazine 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE 1-(3-PHENYLPROPYL)PIPERAZINE 5-Isoquinolinesulfonic acid 1-Acetylpiperazine 4-Methyl-1-piperazineethanamine 1-Piperazineethanamine,N,4-dimethyl-(9CI) 1-(4-phenylpiperazin-1-yl)propan-2-amine 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE 1-ETHYL-4-PHENYLPIPERAZINE N-[2-(4-HYDROXYPHENYL)ETHYL]-METHANESULFONAMIDE 2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE KN-62 N-phenethylmethanesulphonamide 1-(PROPANOYL)-PIPERAZINE KN-62 **NOT FOR SALE IN JAPAN** KN-62: HBC COMPLEX

  • 1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR
  • KN-62 97%
  • KN-62, 99+%
  • 4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid
  • 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester,
  • 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
  • (s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
  • CS-756
  • KN-62 - CAS 127191-97-3 - Calbiochem
  • KN 62;KN-2
  • KN-2
  • (S)-4-(2-(N-methylisoquinoline-5-suNLFonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-suNLFonate
  • N 62
  • KN 62; KN62
  • (1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL)4-PHENYLPIPERAZINE) KN 62
  • (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine
  • 4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester
  • 5-Isoquinolinesulfonic acid 4-[(S)-2-[[(isoquinolin-5-yl)sulfonyl]methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
  • KN-62,97%
  • 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo- 3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacid ester KN-62
  • (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate
  • (S)-4-(2-(N-Methylisoquinoline-5-sulfonaMido)-3-oxo-3-(4-phenylp
  • KN-62, >=98%
  • (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonat
  • KN-62;KN 62; KN62
  • (S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl is
  • KN-62
  • 4-[(2S)-2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]-3-OXO-3-(4-PHENYL-1-PIPERAZINYL)PROPYL] PHENYL ISOQUINOLINESULFONIC ACID ESTER
  • 1-[N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE
  • 5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)MethylaMino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)-
  • (S)-5-ISOQUINOLINESULFONIC ACID 4-(2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]- 3-OXO-3-[4-PHENYL-1-PIPERAZINYL]PROPYL)PHENYL ESTER
  • KN-62 USP/EP/BP
  • [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate
  • noncompetitive antagonism,KN-62,KN 62,inhibit,P2XRs,Calmodulin-dependent protein kinases,HEK293 cells,P2X Receptor,Calmodulin-dependent kinases,CaMK,Inhibitor,autophosphorylation,KN62
  • KN-62, CaM kinase II inhibitor. P2X7 antagonist.
  • 127191-97-3
  • C38H35O6S2
  • C38H35N5O6S2
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Calcium/Calmodulin-Dependent Protein Kinase (CaMK)
  • BioChemical
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Inhibitor
  • Protein Kinase
  • Protein Kinase Inhibitors and Activators