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Methenolone acetate

Product Name
Methenolone acetate
CAS No.
434-05-9
Chemical Name
Methenolone acetate
Synonyms
nibal;sh567;sh567a;PriMo A;sq16496;pirmo a;NSC 74226;17-Acetate;premobolan;primobolan
CBNumber
CB8446910
Molecular Formula
C22H32O3
Formula Weight
344.49
MOL File
434-05-9.mol
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Methenolone acetate Property

Melting point:
138-139°
Boiling point:
419.57°C (rough estimate)
Density 
1.0906 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 3.6 mg/mL (10.45 mM)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C22H32O3/c1-13-11-16(24)12-15-5-6-17-18-7-8-20(25-14(2)23)21(18,3)10-9-19(17)22(13,15)4/h11,15,17-20H,5-10,12H2,1-4H3/t15-,17-,18-,19-,20-,21-,22-/s3
InChIKey
PGAUJQOPTMSERF-MQEWATRANA-N
SMILES
[C@]12([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC[C@@]1([H])CC(=O)C=C(C)[C@]21C)OC(=O)C |&1:0,4,6,10,12,16,24,r|
CAS DataBase Reference
434-05-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
099254
Product name
Methenolone acetate
Purity
95+%
Packaging
1g
Price
$525
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006383
Product name
METHENOLONE ACETATE
Purity
95.00%
Packaging
10MG
Price
$739.2
Updated
2021/12/16
Matrix Scientific
Product number
099254
Product name
Methenolone acetate
Purity
95+%
Packaging
5g
Price
$855
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006383
Product name
METHENOLONE ACETATE
Purity
95.00%
Packaging
100MG
Price
$1871.1
Updated
2021/12/16
Crysdot
Product number
CD33000297
Product name
Methenoloneacetate
Purity
98+%
Packaging
10g
Price
$750
Updated
2021/12/16
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Methenolone acetate Chemical Properties,Usage,Production

Description

Methenolone acetate (Brand name: Primobolan) is a synthetic, orally active anabolic-androgenic steroid and dihydrotestosterone (DHT) derivative. It can be used for the treatment of bone marrow disease and anemia. Methenolone acetate is known for its higher therapeutic efficiency and lower hepatic toxicity compared with its 17 alpha- alkylated analogs. However, it is frequently abused in human sports because of its capability of increasing muscle strength as well as promoting performance and aggressiveness. It is capable of enhancing performance in racehorses.

Chemical Properties

White Solid

Originator

Primobolan ,Schering ,W. Germany,1961

Uses

Methenolone acetate is an anabolic steroid. This is a controlled substance.

Definition

ChEBI: Methenolone acetate is a steroid ester.

Manufacturing Process

8.42 ml of methyl iodide are slowly added dropwise at room temperature with stirring in a nitrogen atmosphere to 3.067 g of magnesium turnings and 107 ml of absolute ether. After about 30 minutes, 185 ml of absolute tetrahydrofuran are slowly introduced and then liquid is distilled off until a boiling point of 62°C is reached. After cooling to room temperature, 613 mg of cuprous chloride are added and then 10 g of ?1,4,6-androstatrien-17β-ol-3- one-17-acetate in 110 ml of tetrahydrofuran slowly introduced. After 30 minutes reaction time, the whole is cooled to 0C, the excess of Grignard reagent decomposed with saturated ammonium chloride solution, the product diluted with ether and the aqueous phase separated. The ethereal phase is washed consecutively with aqueous sodium thiosulfate solution, saturated ammonium chloride solution and water. It is dried over sodium sulfate and evaporated to dryness under vacuum. The residue is dissolved in 40 ml of pyridine and 20 ml of acetic anhydride and the solution kept for 16 hours at room temperature. It is then stirred into ice water and the precipitate filtered with suction, dried and recrystallized from isopropyl ether. 1α-Methyl-?4,6- androstadien-17β-ol-3-one-17-acetate is obtained. MP 156°C to 157°C; [α]D25 = -33.8° (in CHCl3; c = 0.9). Yield 65-70% of the theoretical.
4.67 g of 1α-methyl-?4,6-androstadien-17β-ol-3-one-17-acetate are dissolved in 273 ml of methanol and, after the addition of 350 mg of 10% palladium on calcium carbonate catalyst, hydrogenated until 1 mol equivalent of hydrogen has been taken up. After filtering off the catalyst, the solution is treated with 150 ml of 2N-hydrochloric acid and evaporated under vacuum to about 1/3 of the volume. The whole is then diluted with water and extracted with ether. The ethereal solution is washed with water until neutral, dried over sodium sulfate and evaporated. The crude product is heated on a steam bath for 90 minutes in 10 ml of pyridine and 10 ml of acetic anhydride. Extraction with ether is then carried out and the ethereal phase washed until neutral with water. The crude crystalline 1α-methyl-?4-androsten-17β-ol-3-one-17- acetateobtained after drying and evaporation of the solution, melts at 122°C to 129°C. Yield 98% of the theoretical.
1α-Methyl-?4-androsten-17β-ol-3-one-17-acetate when purified by recrystallization from isopropyl ether melts at 138°C to 139°C.

Therapeutic Function

17β-Hydroxy-1β-methyl-5α-androst-l-ene-3-one acetate

References

Ho, Emmie N. M., et al. "Metabolic studies of methenolone acetate in horses." Analytica Chimica Acta 540.1(2005): 111-119.
https://en.wikipedia.org/wiki/Metenolone_acetate

Methenolone acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methenolone acetate Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Methenolone acetate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Metenolone Acetate 434-05-9
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-15
hebei hongtan Biotechnology Co., Ltd
Product
Methenolone Acetate 434-05-9
Price
US $90.00-70.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-05-11
CONTIDE BIOTECH CO.,LTD
Product
Methenolone Acetate 434-05-9
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-04-12

434-05-9, Methenolone acetateRelated Search:


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