ChemicalBook > CAS DataBase List > (2-Hydroxypropyl)-γ-cyclodextrin

(2-Hydroxypropyl)-γ-cyclodextrin

Product Name
(2-Hydroxypropyl)-γ-cyclodextrin
CAS No.
128446-34-4
Chemical Name
(2-Hydroxypropyl)-γ-cyclodextrin
Synonyms
HPGCD;HP-gamma-CD;CAVASOL(R)W8;Cavasol? W8 HP;Calcium Dobesilate Capsules;2-FLUORO-4-METHYL-1-NITROBENZENE;HydroxypropyI Gamma Cyclodextrin;(2-Hydroxypropyl)-γ-cyclodextrin,HGC;g-Cyclodextrin, 2-hydroxypropylethers;(2-Hydroxyapropyl)-gamma-cyclodextrin
CBNumber
CB8449476
Molecular Formula
C48H80-nO40.(C3H7O)n
Formula Weight
0
MOL File
128446-34-4.mol
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(2-Hydroxypropyl)-γ-cyclodextrin Property

Melting point:
52-55 °C(lit.)
Boiling point:
97-98 °C3 mm Hg(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
H2O: soluble450mg/mL
form 
Solid powder
color 
white
PH
6-9 (2% in H2O)
optical activity
[α]20/D +145°, c = 1 in H2O
InChIKey
WZMOWQCNPFDWPA-UHFFFAOYSA-N
CAS DataBase Reference
128446-34-4(CAS DataBase Reference)
Absorption
≤1.7 at 220-350nm in solution at 2%
≤1.7 at 350-660nm in solution at 2%
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HS Code 
2940000080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H125
Product name
(2-Hydroxypropyl)-γ-cyclodextrin
Purity
solid
Packaging
5G
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
H125
Product name
(2-Hydroxypropyl)-γ-cyclodextrin
Purity
solid
Packaging
100g
Price
$1050
Updated
2024/03/01
Sigma-Aldrich
Product number
390704
Product name
(2-Hydroxypropyl)-γ-cyclodextrin
Purity
extent of labeling: 0.6 molar substitution
Packaging
5g
Price
$78.8
Updated
2024/03/01
Sigma-Aldrich
Product number
390704
Product name
(2-Hydroxypropyl)-γ-cyclodextrin
Purity
extent of labeling: 0.6 molar substitution
Packaging
25g
Price
$168
Updated
2024/03/01
Sigma-Aldrich
Product number
779229
Product name
(2-Hydroxypropyl)-γ-cyclodextrin
Purity
Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, ≥98.0% (HPLC)
Packaging
100g
Price
$490
Updated
2024/03/01
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(2-Hydroxypropyl)-γ-cyclodextrin Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

For R&D use

General Description

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.

Biological Activity

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. HPγCD treatment promotes a wide distribution of lysosomes across the cytoplasm in NPC1 patient-derived fibroblasts. In contrast, lysosomes are clustered near the cell center in untreated cells, raising the possibility that HPγCD has the potential to modulate lysosomal dynamics and functions[1]. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation. Industrially produced HPγCD, which is used as a complexing agent in new ophthalmic formulations, is not a single compound but a heterogeneous, complex mixture of homologues and isomers substituted by a variable number of 2-hydroxy-propyl groups at different positions of the sugar moieties[2].

References

[1] Ashutosh Singhal. “2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy.” Scientific Reports (2020): 8663.
[2] W Blum . "Determination of 2-hydroxypropyl-γ-cyclodextrin in plasma of cynomolgus monkeys after oral administration by gas chromatography–mass spectrometry.” Journal of Chromatography B: Biomedical Sciences and Applications 720 1 (1998): Pages 171-178.

(2-Hydroxypropyl)-γ-cyclodextrin Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Hydroxypropyl)-γ-cyclodextrin Suppliers

China 156 Germany 2 India 3 Japan 2 Switzerland 2 United Kingdom 9 United States 19 Global 193
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View Lastest Price from (2-Hydroxypropyl)-γ-cyclodextrin manufacturers

Watson Biotechnology Co.,Ltd
Product
(2-Hydroxypropyl)-gamma-cyclodextrin 128446-34-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-08-14
Wuhan Fortuna Chemical Co.,Ltd
Product
(2-Hydroxypropyl)-γ-cyclodextrin 128446-34-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-08-10
Shanghai UCHEM Inc.
Product
(2-Hydroxypropyl)-gamma-cyclodextrin 128446-34-4
Price
US $62.00-196.00/g
Min. Order
25g
Purity
0.98
Supply Ability
25kg
Release date
2023-10-30

128446-34-4, (2-Hydroxypropyl)-γ-cyclodextrinRelated Search:

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