2-FLUORO-4-METHYLPHENOL

Product Name: 2-FLUORO-4-METHYLPHENOL
CAS No.: 452-81-3
Chemical Name: 2-FLUORO-4-METHYLPHENOL
Synonyms: 2-Fluoro-p-cresol;2-FLUORO-4-METHYLPHENOL;Phenol, 2-fluoro-4-methyl-;3-Fluoro-4-hydroxytoluene, 2-Fluoro-p-cresol
CBNumber: CB8451882
Molecular Formula: C7H7FO
Formula Weight: 126.13
MOL File: 452-81-3.mol

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2-FLUORO-4-METHYLPHENOL Property

Boiling point:: 173.0±20.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
refractive index: 1.513
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 9.01±0.18(Predicted)
form: liquid
color: Clear, colourless
InChI: InChI=1S/C7H7FO/c1-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3
InChIKey: WJKISRFVKIOBCQ-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(C)C=C1F

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-34-22
Safety Statements: 26-36/37/39
RIDADR: 2922
Hazard Note: Irritant
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 2908990000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: F597140
Product name: 2-Fluoro-4-methylphenol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F597140
Product name: 2-Fluoro-4-methylphenol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC5944
Product name: 2-Fluoro-4-methylphenol
Packaging: 25g
Price: $103
Updated: 2021/12/16

Apolloscientific

Product number: PC5944
Product name: 2-Fluoro-4-methylphenol
Packaging: 100g
Price: $317
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2701-3-06
Product name: 2-Fluoro-4-methylphenol
Packaging: 25g
Price: $136
Updated: 2021/12/16

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2-FLUORO-4-METHYLPHENOL Chemical Properties,Usage,Production

Synthesis

106-44-5

452-81-3

77249-33-3

GENERAL METHOD: To a solution of the substrate 4-methylphenol (1 mmol) in 10 mL of solvent (acetonitrile or methanol) was added Fluoride Reagent 1, 2 or 3 (1.1 mmol). The reaction mixture was stirred under reflux conditions for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in 50 mL of dichloromethane and filtered to remove insoluble material. The filtrate was washed with 30 mL of water and the organic layer was dried with anhydrous sodium sulfate followed by evaporation of the solvent. The crude product was analyzed by 1H NMR and 19F NMR spectroscopy. The relative distribution and total yield of the fluorinated products were determined by 19F NMR using octafluoronaphthalene (OFN) as an internal standard. The identification of the products was accomplished by comparing their NMR spectral data with those reported in the literature, independently prepared samples, or their conversion to known compounds. In the presence of excess reagents, 2-fluoro-4-alkyl-substituted phenols or alkoxybenzenes (5, see Scheme 1) can be converted to 2,2-difluoro-4-alkyl-3,5-cyclohexadienones (unknown compounds 8b or 8c) or hydrolyzed to 2-fluoro-4-methylphenols (4aa). 4-fluoro-4-alkyl-2,5-cyclohexadienones (6a, 6b, and 6c) were determined by preparative thin layer chromatography (silica gel , dichloromethane/petroleum ether, 4:1) from the crude mixture and identified on the basis of their spectral data. Also, 4-fluoroalkoxybenzene derivatives could be identified by hydrolytic conversion to 4-fluorophenol or by comparison with independently prepared compounds.

References

[1] Journal of Fluorine Chemistry, 1981, vol. 17, p. 159 - 172
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 17, p. 2469 - 2474
[3] Journal of Fluorine Chemistry, 1981, vol. 17, p. 159 - 172
[4] Journal of Fluorine Chemistry, 2013, vol. 156, p. 276 - 282
[5] Tetrahedron, 2006, vol. 62, # 18, p. 4474 - 4481

2-FLUORO-4-METHYLPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-4-METHYLPHENOL Suppliers

Belgium 1 China 94 France 2 Germany 4 India 6 The Netherlands 1 United Kingdom 11 United States 22 Global 141

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View Lastest Price from 2-FLUORO-4-METHYLPHENOL manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-FLUORO-4-METHYLPHENOL 452-81-3
Price: US $40.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-05

452-81-3, 2-FLUORO-4-METHYLPHENOLRelated Search:

3-Fluoro-4-methoxybenzaldehyde 2-FLUORO-4-METHYLANISOLE 3-FLUORO-4-METHOXYPHENYLACETIC ACID 3-Fluoro-4-methoxyacetophenone 3-(3-FLUORO-4-METHOXYBENZOYL)PROPIONIC ACID 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE OCTAFLUORO-4,4'-BIPHENOL 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 3-FLUORO-L-TYROSINE 3-Fluoro-4-hydroxybenzaldehyde 3-FLUORO-4-HYDROXYPHENYLACETIC ACID 3-FLUORO-4-METHOXYPHENYLACETONITRILE 3-Fluoro-4-methoxybenzoic acid 3-FLUORO-2-METHYLPHENOL,3-Fluoro-2-methylphenol98% 2,3-DIFLUORO-4-METHYLPHENOL Phenol, 2,6-difluoro-3-methyl- (9CI) 2-CHLORO-6-FLUORO-3-METHYLPHENOL 6-CHLORO-2-FLUORO-3-METHYLPHENOL

2-Fluoro-p-cresol

2-FLUORO-4-METHYLPHENOL

3-Fluoro-4-hydroxytoluene, 2-Fluoro-p-cresol

Phenol, 2-fluoro-4-methyl-

452-81-3

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