O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
- Product Name
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
- CAS No.
- 6723-30-4
- Chemical Name
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
- Synonyms
- )-hydroxyL;O-(Tetrahydropyran-2-yL;O-(oxan-2-yl)hydroxylaMine;2-(Aminooxy)tetrahydro-2H-pyran;O-2-tetrahydro-2H-pyranhydroxylamine;O-(TETRAHYDRO-PYRAN-2-YL)-HYDROXYLAMINE;O-tertrahydroxy-pyran-2-yl-hydroxylamine;O-(2H-Tetrahydropyran-2-yl)hydroxylamine;O-(TETRAHYDRO-2H-PYRAN-2-YL)HYDROXYLAMINE;O-(Tetrahydropyran-2-yl)hydroxylamine, 96%,
- CBNumber
- CB8452849
- Molecular Formula
- C5H11NO2
- Formula Weight
- 117.15
- MOL File
- 6723-30-4.mol
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Property
- Melting point:
- 34-37 °C (lit.)
- Boiling point:
- 81 °C/20 mmHg (lit.)
- Density
- 1.1274 (rough estimate)
- refractive index
- 1.4206 (estimate)
- Flash point:
- 180 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.28±0.20(Predicted)
- form
- Low Melting Solid
- color
- White
- InChI
- InChI=1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2
- InChIKey
- NLXXVSKHVGDQAT-UHFFFAOYSA-N
- SMILES
- NOC1OCCCC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 480894
- Product name
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
- Purity
- 96%
- Packaging
- 1g
- Price
- $80.5
- Updated
- 2025/07/31
- Product number
- T2598
- Product name
- O-(Tetrahydropyran-2-yl)hydroxylamine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- T2598
- Product name
- O-(Tetrahydropyran-2-yl)hydroxylamine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- T889565
- Product name
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- JK560184
- Product name
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine can be used to treat fibrotic and inflammatory diseases.
Uses
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as an oximation reagent in the synthesis of a marine alkaloid which shows significant inhibitory activity against mycothiol S-conjugate amidase.
General Description
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.
Synthesis
110-87-2
6723-30-4
General procedure for the synthesis of O-(tetrahydro-2H-pyran-2-yl)hydroxylamine from 3,4-dihydro-2H-pyran: N-hydroxyphthalimide (10 g, 0.061 mol) and 3,4-dihydro-2H-pyran (6.1 g, 0.073 mol) were added to a 250 mL three-necked flask, and tetrahydrofuran (100 mL) was added to dissolve. Subsequently, p-toluenesulfonic acid (1.1 g, 6.1 mmol) was added to catalyze the reaction. The reaction was carried out at room temperature for 2 hours. Upon completion of the reaction, the tetrahydrofuran was removed by distillation under reduced pressure. Water (200 mL) was added to the residue and extracted with dichloromethane (3 x 200 mL). The organic phases were combined and washed sequentially with saturated aqueous NaHCO3 solution (3 x 200 mL) and saturated aqueous NaCl solution (200 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated to dryness to give a yellow-green solid (15.3 g). The resulting solid was transferred to a 1000 mL three-necked flask and ethanol (450 mL) was added and stirred to dissolve. 80% hydrazine hydrate (10.4 mL, 0.17 mol) was slowly added dropwise and the reaction was carried out for 1 hour at room temperature. The reaction solution was directly filtrated and the filtrate was evaporated to give the crude product (10.6 g). The crude product was dissolved with ethyl acetate (500 mL), mixed thoroughly and vacuum filtered to remove insoluble matter. The filtrate was washed with water (3×100 mL) and saturated NaCl aqueous solution (200 mL) sequentially, dried with anhydrous sodium sulfate and filtered, evaporated to dryness to obtain a light yellow oil. The oily material was dried under vacuum to give a yellow solid (5.39 g) with a melting point of 35-37 °C and a yield of 75.3%.
References
[1] Organic Letters, 2006, vol. 8, # 18, p. 4035 - 4038
[2] Patent: CN107400131, 2017, A. Location in patent: Paragraph 0031; 0063-0065
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 21, p. 4197 - 4210
[4] Patent: WO2012/96832, 2012, A2
[5] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 2, p. 168 - 175
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine manufacturers
- Product
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine 6723-30-4
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-05
- Product
- O-(Tetrahydropyran-2-yl)-hydroxylamine 6723-30-4
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine 6723-30-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13