ChemicalBook > CAS DataBase List > Boc-1-amino-3,6-dioxa-8-octanediamine

Boc-1-amino-3,6-dioxa-8-octanediamine

Product Name: Boc-1-amino-3,6-dioxa-8-octanediamine
CAS No.: 153086-78-3
Chemical Name: Boc-1-amino-3,6-dioxa-8-octanediamine
Synonyms: BOC-NH-PEG2-NH2;NHBoc-PEG3-NH2;N-BOC-2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;{2-[2-(2-AMino-ethoxy)-ethoxy]-ethyl}-carbaMic acid tert-butyl ester;BOC-DOOA;NH2-PEG2-NHBOC;NHBoc-PEG2-amine;PROTAC Linker 13;BOC-N-AMIDO-PEG2-NH2;Boc-NH-PEG2-CH2CH2NH2
CBNumber: CB8456887
Molecular Formula: C11H24N2O4
Formula Weight: 248.32
MOL File: 153086-78-3.mol

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Boc-1-amino-3,6-dioxa-8-octanediamine Property

Boiling point:: 365.2±27.0 °C(Predicted)
Density: 1.046 g/mL at 20 °C
refractive index: 1.4570 to 1.4610
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: clear liquid
pka: 12.23±0.46(Predicted)
color: Colorless to Light yellow to Light orange
InChI: InChI=1S/C11H24N2O4/c1-11(2,3)17-10(14)13-5-7-16-9-8-15-6-4-12/h4-9,12H2,1-3H3,(H,13,14)
InChIKey: OCUICOFGFQENAS-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCOCCN

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: 2735
WGK Germany: 3
F: 10-21
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 89761
Product name: N-Boc- 2,2′-(ethylenedioxy)diethylamine
Purity: ≥95.0% (NT)
Packaging: 1g
Price: $228
Updated: 2025/07/31

Sigma-Aldrich

Product number: 89761
Product name: N-Boc- 2,2′-(ethylenedioxy)diethylamine
Purity: ≥95.0% (NT)
Packaging: 5G
Price: $611.8
Updated: 2025/07/31

TCI Chemical

Product number: B5141
Product name: N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine
Purity: >97.0%(HPLC)(T)
Packaging: 200mg
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: B5141
Product name: N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $276
Updated: 2025/07/31

Usbiological

Product number: 262064
Product name: Boc-1-amino-3,6-dioxa-8-octanediamine
Packaging: 500mg
Price: $340
Updated: 2021/12/16

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Boc-1-amino-3,6-dioxa-8-octanediamine Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG2-amine is a PEG linker containing an amino group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Light yellow oil

Uses

Linker reagent for the prep. of a broad variety of linked tags, monomers for polymerisation, ionophores etc., e.g. biotinylation reagents.

reaction suitability

reagent type: cross-linking reagent

Synthesis

929-59-9

24424-99-5

153086-78-3

General procedure: A dichloromethane solution (10 mL/mmol) of 1,8-diamino-3,6-dioxaoctane (1 eq.) was treated with di-tert-butyl dicarbonate (0.15 eq.) at 0 °C, kept at 0 °C for 5 hours, and then the reaction was continued at room temperature for 18 hours. Upon completion of the reaction, the organic phase was washed with water until all unreacted 1,8-diamino-3,6-dioxaoctane was removed by extraction. The organic phase was dried over anhydrous magnesium sulfate and recovered quantitatively to give the Boc-protected product tert-butyl 2-(2-(2-aminoethoxy)ethoxy)ethylcarbamate, which was concentrated under vacuum. The product characterization data were as follows:11a: 1H NMR (300 MHz, CDCl3): δ 1.45 (s, 9H), 1.80 (br m, 2H, NH2), 3.25 (m, 2H), 3.38 (m, 2H), 3.50-3.70 (m, 8H), 5.10 (br s, 1H, NHCO2).11b: 1H NMR ( 300 MHz, CDCl3): δ 1.42 (s, 9H), 1.75 (br m, 2H, NH2), 2.84 (t, 2H, J = 5.3 Hz), 3.29 (m, 2H), 3.51 (m, 4H), 3.58 (sharp m, 8H), 5.30 (br s, 1H, NHCO2).

IC 50

PEGs

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 15, p. 4208 - 4212
[2] Tetrahedron, 2012, vol. 68, # 52, p. 10818 - 10826
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2678 - 2685
[4] Journal of the American Chemical Society, 2013, vol. 135, # 34, p. 12684 - 12689
[5] Tetrahedron, 2017, vol. 73, # 33, p. 4972 - 4978

Boc-1-amino-3,6-dioxa-8-octanediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-1-amino-3,6-dioxa-8-octanediamine Suppliers

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View Lastest Price from Boc-1-amino-3,6-dioxa-8-octanediamine manufacturers

LAURENT

Product: BocNH-PEG2-CH2CH2NH2 153086-78-3
Price: US $8824.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-15

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: tert-butyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate 153086-78-3
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

Jinan Ruitong Biotech Co., Ltd.

Product: tert-Butyl [2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate 153086-78-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

153086-78-3, Boc-1-amino-3,6-dioxa-8-octanediamineRelated Search:

2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-thiol alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol) PENTAETHYLENE GLYCOL MONOMETHYL ETHER alpha-aMine-oMega-propionic acid hexaethylene glycol Nonaethylene glycol alpha, oMega-Dipropionic acid dodecaethylene glycol alpha, oMega-Dipropionic acid triethylene glycol 20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine NONAETHYLENE GLYCOL MONOMETHYL ETHER BIOTIN-XX-NHS alpha-aMine-oMega-propionic acid octaethylene glycol H2N-PEG24-tBu 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL 1-Azidohexaethylene Glycol tert-Butyl N-{2-[(5-cyanopyridin-2-yl)amino]ethyl}carbamate tert-butyl 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenethylcarbaMate tert-Butyl N-{2-[(2-fluorophenyl)formamido]ethyl}carbamate Boc-1-amino-3,6-dioxa-8-octanediamine

BOC-1-AMINO-3,6-DIOXA-8-OCTANEDIAMINE

BOC-DOOA

1-(TERT-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE

1-(T-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE

tert-butyl N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate

Boc-1-amino-3,6-dioxa-8-octanediamine(Boc-NH-PEG3)

t-BocNH-PEG2-CH2CH2NH2

t-Boc-N-amido-PEG2-Amine 98%

TERT-BUTYL 2-[2-(2-AMINOETHOXY)ETHOXY]ETHYLCARBAMATE

N-BOC-3,6-DIOXA-1,8-OCTANEDIAMINE

N-BOC-2,2'-(ETHYLENEDIOXY)DIETHYLAMINE

1-(TERT-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE, LIQ.

1-(T-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE, LIQ.

5,8-dioxa-2-azadiheptaoic acid, 10-aMino-,1,1-diMethylethyl ester

Boc-NH-PEG2-CH2CH2NH2

{2-[2-(2-AMino-ethoxy)-ethoxy]-ethyl}-carbaMic acid tert-butyl ester

N-Boc- 2,2'-(ethylenedioxy)diethylaMine >=95.0% (NT)

CarbaMic acid,N-[2-[2-(2-aMinoethoxy)ethoxy]ethyl]-, 1,1-diMethylethyl ester

t-Boc-N-amido-PEG2-Amine

N-Boc- 2,2′-(ethylenedioxy)diethylamine, >=98%

N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine

Boc-N-amido-PEG2-Amine

N-Boc-3,6-dioxaoctane-1,8-diamine

Boc-NH-PEG3 Boc-1-amino-3,6-dioxa-8-octanediamine

tert-Butyl (2-(2-(2-aminoethoxy)

N-Boc-2-[2-(2-amino-ethoxy)-ethoxy]-ethylamine

Boc-1-amino-3,6-dioxa-8-octanediamine≥ 97% (Titration)

BOC-N-AMIDO-PEG2-NH2

BOC-NH-PEG2-NH2

NHBoc-PEG3-NH2

NHBoc-PEG2-amine

PROTAC Linker 13

Boc-N-amido-PEG2-Amine,t-boc-N-amido-PEG2-amine

N-tert-Butyloxycarbonyl-1,8-diamino-3,6-dioxaoctane

N-(tert-Butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

N-Boc-2-[2-(2-amino-ethoxy)-etho

t-Boc-Amido-PEG3-Amine

NH2-PEG2-NHBOC

Boc-N-amido-PEG2-Amine t-boc-N-amido-PEG2-amin

N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)

N-Boc-2,2’-(ethylenedioxy)diethylamine

<i>N</i>-Boc- 2,2′-(ethylenedioxy)diethylamine

153086-78-3

153086-78-8

C11H24N2O4

Bifunctional Crosslinkers

Specialty Synthesis

Peptide Synthesis

Linkers

peg