ChemicalBook > CAS DataBase List > 5-BROMO-2-METHYL-3-NITROBENZOIC ACID

5-BROMO-2-METHYL-3-NITROBENZOIC ACID

Product Name
5-BROMO-2-METHYL-3-NITROBENZOIC ACID
CAS No.
107650-20-4
Chemical Name
5-BROMO-2-METHYL-3-NITROBENZOIC ACID
Synonyms
AKOS BB-9545;-3-nitrobenzoic acid;5-Bromo-2-methyl-3-nitrobenzoicAci;5-BROMO-2-METHYL-3-NITROBENZOIC ACID;Benzoic acid, 5-broMo-2-Methyl-3-nitro-;5-BROMO-2-METHYL-3-NITROBENZOIC ACID ISO 9001：2015 REACH
CBNumber
CB8460277
Molecular Formula
C8H6BrNO4
Formula Weight
260.04
MOL File
107650-20-4.mol
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5-BROMO-2-METHYL-3-NITROBENZOIC ACID Property

Boiling point:
377.0±42.0 °C(Predicted)
Density 
1.777±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
2?+-.0.20(Predicted)
InChI
InChI=1S/C8H6BrNO4/c1-4-6(8(11)12)2-5(9)3-7(4)10(13)14/h2-3H,1H3,(H,11,12)
InChIKey
DXUUJILVHXQDCV-UHFFFAOYSA-N
SMILES
C1(C(C)=C(C(=O)O)C=C(Br)C=1)[N+]([O-])=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B687510
Product name
5-Bromo-2-methyl-3-nitrobenzoicAcid
Packaging
10g
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0105115
Product name
5-BROMO-2-METHYL-3-NITROBENZOIC ACID
Purity
95.00%
Packaging
1G
Price
$145.95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB32995
Product name
5-Bromo-2-methyl-3-nitrobenzoic acid
Packaging
5G
Price
$150
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0105115
Product name
5-BROMO-2-METHYL-3-NITROBENZOIC ACID
Purity
95.00%
Packaging
10G
Price
$1589.28
Updated
2021/12/16
AK Scientific
Product number
X8853
Product name
5-Bromo-2-methyl-3-nitrobenzoicacid
Packaging
1g
Price
$20
Updated
2021/12/16
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5-BROMO-2-METHYL-3-NITROBENZOIC ACID Chemical Properties,Usage,Production

Uses

5-Bromo-2-methyl-3-nitrobenzoic Acid is a reactant in the preparation of EPZ005687 (E592200), a potent and selective inhibitor of EZH2.

Synthesis

1975-50-4

107650-20-4

General procedure for the synthesis of 2-methyl-3-nitro-5-bromobenzoic acid from 2-methyl-3-nitrobenzoic acid: N-bromosuccinimide (15 g, 84.3 mmol) was added to a concentrated sulfuric acid solution (60 mL) containing 2-methyl-3-nitrobenzoic acid (15 g, 82.8 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was slowly poured into ice water (400 mL). The precipitate was collected by filtration and dried under vacuum to give 21 g of the target product 2-methyl-3-nitro-5-bromobenzoic acid in 98% yield.

References

[1] Patent: US2012/264734, 2012, A1. Location in patent: Page/Page column 100
[2] Patent: WO2012/142513, 2012, A1. Location in patent: Page/Page column 288
[3] Patent: US2014/107122, 2014, A1. Location in patent: Paragraph 0157; 0158
[4] Patent: WO2003/99275, 2003, A1. Location in patent: Page 101
[5] Patent: US2007/219212, 2007, A1. Location in patent: Page/Page column 23

5-BROMO-2-METHYL-3-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-METHYL-3-NITROBENZOIC ACID Suppliers

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View Lastest Price from 5-BROMO-2-METHYL-3-NITROBENZOIC ACID manufacturers

Henan Fengda Chemical Co., Ltd
Product
5-Bromo-2-methyl-3-nitrobenzoic acid 107650-20-4
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-BROMO-2-METHYL-3-NITROBENZOIC ACID 107650-20-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-BROMO-2-METHYL-3-NITROBENZOIC ACID 107650-20-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

107650-20-4, 5-BROMO-2-METHYL-3-NITROBENZOIC ACIDRelated Search:

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