Outline Chemical Properties Uses Reaction of binary biuret Production method
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Biuret

Outline Chemical Properties Uses Reaction of binary biuret Production method
Product Name
Biuret
CAS No.
108-19-0
Chemical Name
Biuret
Synonyms
IMIDODICARBONIC DIAMIDE;Dicarbonimidic diamide;iuret;BIURET REAGENT;L-101;biure;BIURET;BiuretGr;Isobiuret;Biuret,98%
CBNumber
CB8460994
Molecular Formula
C2H5N3O2
Formula Weight
103.08
MOL File
108-19-0.mol
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Biuret Property

Melting point:
185-190 °C (dec.) (lit.)
Boiling point:
100 °C
Density 
1.01 g/mL at 20 °C
refractive index 
1.4264 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka
10.17±0.46(Predicted)
form 
Liquid
color 
White
Odor
Odorless
Water Solubility 
2 g/100 mL (25 ºC)
Sensitive 
Hygroscopic
Merck 
14,1309
BRN 
1703510
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases. Hygroscopic.
CAS DataBase Reference
108-19-0(CAS DataBase Reference)
NIST Chemistry Reference
Imidodicarbonic diamide(108-19-0)
EPA Substance Registry System
Imidodicarbonic diamide (108-19-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37-36
WGK Germany 
3
TSCA 
Yes
HS Code 
29241990
Hazardous Substances Data
108-19-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2603
Product name
Urea Related Compound A
Packaging
30MG
Price
$267
Updated
2024/03/01
Sigma-Aldrich
Product number
15270
Product name
Biuret
Purity
98%
Packaging
25g
Price
$84.6
Updated
2024/03/01
Sigma-Aldrich
Product number
15270
Product name
Biuret
Purity
98%
Packaging
100g
Price
$268
Updated
2024/03/01
TCI Chemical
Product number
B0513
Product name
Biuret (contains ca. 10% Triuret)
Purity
>98.0%(N)
Packaging
25g
Price
$90
Updated
2024/03/01
TCI Chemical
Product number
B0513
Product name
Biuret (contains ca. 10% Triuret)
Purity
>98.0%(N)
Packaging
500g
Price
$755
Updated
2024/03/01
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Biuret Chemical Properties,Usage,Production

Outline

Biuret is the resulting product in urea production process by deamination and condensation reaction when the temperature is higher than the melting point of urea (150-170 ℃). Formula is NH2CONHCONH2. Reaction is as follows NH2CONH2-(heating)-> HNCO + NH3, HNCO + NH2CONH2 → NH2CONHCONH2, crystallization of urea in the granulation process will generate biuret, this substance is toxic to plants, thus content of biuret in urea is required not exceed 1%. Top dressing with urea, the content of biuret should not exceed 0.5%.

Chemical Properties

It is long white sheet crystals. Melting point is 190 ℃ (decomposition), the relative density is 1.467 (-5/4 ℃). Crystals in water contain 4 molecules of water of crystallization, dehydrate at about 110 ℃. It is easily soluble in alcohol, very slightly soluble in ether.

Uses

1. Biuret is used in feed for ruminants, as feed additives as urea, like, but more safe than urea.
2. It is used as pharmaceutical intermediates, growth hormone, foaming agents, paints.
3. It is used for chemical analysis.

Reaction of binary biuret

Protein produces purple in alkaline copper sulfate solution, this is because the basic copper sulfate with proteins peptide bond (-NHCO-) formed sake complexes. On the structure of purple product, generally disagree, Xu Fu (Schiff) once separated following the reaction of compound (ⅰ) (purple crystal) from the most simple binary biuret reaction mixture, the chemical reaction equation related is as follows:

Someone studied with a spectrophotometric method, suggesting that the reaction of binary biuret produces a colored substance, which is mainly composed of a tripeptide and tetrapeptide, complexes produced by ligand of copper and tripeptide was purple, complexes produced by ligand of copper with tetrapeptide was red.
This reaction is not very sensitive, because its peptide bond with another substance that has other groups conduct the biuret reaction. Some substances without the peptide bonds (e.g., histidine) may also conduct this reaction, so its work on the application is limited.

Production method

Mix urea, water with disodium hydrogen phosphate, dissolve by heating. It was heated to 150-160 ℃, heat preservation for 2h. The reaction was completed, the reactants were poured into water and allowed to stand overnight, crystals filtered off were crude, and recrystallize with dilute ammonia to give the finished product of biuret. In the production of urea, intermediate urine is as raw material, by high temperature thermal condensation, separation, and drying, the production is obtained.

Chemical Properties

white powder

Uses

Analytical reagent, especially for proteins.

Uses

Biuret is used in protein assay. It is also used as Catalytic agent, Petrochemical additive. It is used in organic synthesis. Biuret (Carbamoylurea) was used as a source of dietary nitrogen in purified diets for steers.

Definition

A colorless crystalline organic compound made by heating UREA (carbamide). It is used in a chemical test for PROTEINS.

Definition

ChEBI: A member of the class of condensed ureas that is the compound formed by the condensation of two molecules of urea; the parent compound of the biuret group of compounds. Used as a non-protein nitrogen source in ruminant feed.

Agricultural Uses

Biuret is a compound formed from urea when the temperature during the manufacture of urea goes above 140 to 170°C. A biuret concentration of more than 2% in urea is harmful to plants as it affects the metabolism of proteins.

Purification Methods

Crystallise biuret from EtOH. [Beilstein 3 IV 141.]

Biuret Preparation Products And Raw materials

Raw materials

Urea

Preparation Products

Polyester resin paint Hexamethylene Diisocyanate Glycine
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Americas 1 Australia 1 Belgium 3 Canada 1 China 300 Europe 6 France 3 Germany 6 India 42 Japan 4 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 United Kingdom 13 United States 53 Global 439
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View Lastest Price from Biuret manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Biuret 108-19-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
Biuret 108-19-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Biuret 108-19-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

108-19-0, BiuretRelated Search:

N,N-Dimethylformamide P-AMINOBENZAMIDE GLUTAMIC ACID Semicarbazide p-Aminobenzamide Sulfanilamide Aminoguanidine bicarbonate Iminodiacetonitrile N,N,N',N'-Tetramethylazodicarboxamide 3-Aminobenzenesulfonamide Iminodiacetic acid OXONIC ACID POTASSIUM SALT 1,3,5-Tris(2-hydroxyethyl)cyanuric acid URAZOLE L-ACYLASE 4-Phenylurazole 1,3,5-Tri-2-propenyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione Trichloroisocyanuric acid Sodium dichloroisocyanurate

  • (aminocarbonyl)-ure
  • Allophamicacidamide
  • Allophanimidic acid
  • allophanimidicacid
  • Dicarbamylamine
  • Dicarbonimidic diamide
  • Isobiuret
  • L-101
  • Urea, (aminocarbonyl)-
  • BiuretGr
  • BIURET REAGENT GR
  • Allophanic acid amide, Carbamoylurea
  • Biuret, 97%, extra pure
  • Shrinkage of two urea
  • EZ-96 KIT TOTAL RNA (12X96)
  • Biuret (contains ca. 10% Triuret)
  • Biuret, extra pure, 97%
  • uridoformamide
  • Biuret, 97+%
  • Biuret [for Fertilizer Analysis]
  • ALLOPHANAMIDE, PURE
  • Biuret, extra pure, 97% 25GR
  • Biuret, extra pure, 97% 5GR
  • Urea Related Compound A
  • Standard solution for the determination of biuret
  • iuret
  • 1-(carbamoylamino)formamide
  • Allophanimidic
  • ZERENEX ZX005314
  • UREIDOFORMAMIDE
  • DICARBAMYLUREA
  • CARBAMOYLUREA
  • CARBAMYLUREA
  • IMIDODICARBONIC DIAMIDE
  • BIURET
  • BIURET REAGENT
  • BIURET REAGENT, GORNALL, BARDAWILL AND DAVID
  • BIURET REAGENT SERUM PROTEIN
  • Biuret reagent solution
  • BIURET REAGENT TS
  • ALLOPHANAMIDE
  • ALLOPHANIC ACID AMIDE
  • ALLOPHANIC AMIDE
  • Biuret Allophanamide
  • Biuret,98%
  • Biuret &gt
  • Biuret(Technical)
  • Biuret [for Fertilizer Analysis]&gt
  • BiuretSolution,100mg/L,100ml
  • (Aminocarbonyl)urea
  • biure
  • Biuret impurity determination standard solution
  • Biuret, GR 96%
  • Biuret 96% AR 25GM
  • Biuret 96% AR 100GM
  • Biuret extrapure AR, 97%
  • Urea Related Compound A (Dicarbonimidic diamide) (1706712)
  • Biuret, ≥ 98.0%