4-[(4-Methylpiperazin-1-yl)methyl]aniline
- Product Name
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline
- CAS No.
- 70261-82-4
- Chemical Name
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline
- Synonyms
- FN1501;AKOS BB-8955;1-methyl-4-(4-aminobenzyl)piperazine;1-(4-Aminobenzyl)-4-methylpiperazine;4-[(4-methyl-1-piperazinyl)methyl]aniline;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE;4-((4-methylpiperazin-1-yl)methyl)benzenamine;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYLAMINE;4-(4-Methylpiperazin-1-ylmethyl)phenylamine95%;4-[(4-Methyl-1-piperazinyl)methyl]-benzenamine
- CBNumber
- CB8464457
- Molecular Formula
- C12H19N3
- Formula Weight
- 205.3
- MOL File
- 70261-82-4.mol
4-[(4-Methylpiperazin-1-yl)methyl]aniline Property
- Melting point:
- 97-99oC
- Boiling point:
- 331.2±27.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 7.65±0.10(Predicted)
- form
- Solid
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M327310
- Product name
- 4-(4-Methylpiperazin-1-ylmethyl)phenylamine
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 010950
- Product name
- 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine
- Packaging
- 500mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 010950
- Product name
- 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- W7980
- Product name
- 4-(4-Methylpiperazin-1-ylmethyl)phenylamine
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
- Product number
- COR0002706
- Product name
- 4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $160.65
- Updated
- 2021/12/16
4-[(4-Methylpiperazin-1-yl)methyl]aniline Chemical Properties,Usage,Production
Uses
4-(4-Methylpiperazin-1-ylmethyl)phenylamine is an intermediate used to prepare aminopyridopyrimidinones as tyrosine kinase inhibitors and anticancer agents. It is also used in the synthesis of piperazinyltrifluoromethylphenylquinolinylbenzonaphthyridinone derivatives with anticancer activities.
Synthesis
70261-81-3
70261-82-4
Step 2: Preparation of 4-(4-methylpiperazin-1-ylmethyl)aniline (F652-02) 1-Methyl-4-(4-nitrobenzyl)piperazine (F652-01, 4.67 g, 19.9 mmol), methanol (100 mL), zinc powder (6.5 g, 99.3 mmol), and ammonium chloride (4.3 g, 79.5 mmol) were added to a reaction vessel and heated and refluxed for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered through diatomaceous earth. The filtrate was distilled under reduced pressure to remove the solvent to give a solid product. Diethyl ether was added to the solid and the insoluble material was removed by filtration. The filtrate was distilled to remove the solvent to give 4-(4-methylpiperazin-1-ylmethyl)aniline (F652-02, white solid, 3.16 g, 77% yield). LC/MS (Method 6): m/z (ESI, POS): 206 [M + H]+; retention time: 1.15 min. 1H-NMR (400 MHz, DMSO-d6) δ 2.12 (s, 3H), 2.29 (bs, 8H), 3.23 (s, 2H), 4.93 (s, 2H), 6.49 (d, J = 8.4 Hz, 2H), 6.89 (d, J = 8.4 Hz, 2H).
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2917 - 2929
[2] Patent: WO2004/46120, 2004, A2. Location in patent: Page 173
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 15, p. 5738 - 5748
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 21, p. 8801 - 8815
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518
4-[(4-Methylpiperazin-1-yl)methyl]aniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(4-Methylpiperazin-1-yl)methyl]aniline Suppliers
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-20958197 20965099
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 1183
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 021-54849683 13601642561
- Fax
- +86-21-54375689
- sales@keepontech.com
- Country
- China
- ProdList
- 998
- Advantage
- 59
- Tel
- 0371-86615086 18203638366 0371-86159066 13526786601
- Fax
- 0371-86159066
- Country
- China
- ProdList
- 2015
- Advantage
- 60
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- +86 (21) 6715-7650
- Fax
- +86 (21) 6715-7651
- sheepchem@163.com
- Country
- China
- ProdList
- 994
- Advantage
- 60
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2337
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 021-61317773
- Fax
- 021-61486878
- sales@aspirebio.com
- Country
- China
- ProdList
- 2880
- Advantage
- 58
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 028-64353063
- Fax
- 028-64353063 QQ:784253935
- reacchemical@163.com
- Country
- China
- ProdList
- 5253
- Advantage
- 58
- Tel
- 021-34979681; 17701870669
- Fax
- 021-34979681
- 41513101@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 55
- Tel
- 21-33526724 18930996265
- Fax
- +86 21 37023730
- info@carlowchem.com
- Country
- China
- ProdList
- 1969
- Advantage
- 50
- Tel
- 18915409046
- Fax
- 0510-86566870
- 1102409417@qq.com
- Country
- China
- ProdList
- 268
- Advantage
- 55
- Tel
- 021-20960837,QQ1332204249
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 3341
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 15801747407
- Fax
- +86 021 51388225
- sales01@suntechpharma.com
- Country
- China
- ProdList
- 123
- Advantage
- 58
- Tel
- 13356901049
- Fax
- QQ：1025383091
- 3119594100@qq.com
- Country
- China
- ProdList
- 7964
- Advantage
- 55
- Tel
- 2332782371
- Fax
- QQ: 2332782371
- adobechem@qq.com
- Country
- China
- ProdList
- 7980
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 13651987816
- Fax
- -
- hongminpharm@163.com
- Country
- China
- ProdList
- 2326
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- +86-188369842 +86-15618151133
- Fax
- QQ188369842
- 188369842@qq.com
- Country
- China
- ProdList
- 1959
- Advantage
- 58
- Tel
- 027-69573188 18221423799
- 1503407886@qq.com
- Country
- China
- ProdList
- 1439
- Advantage
- 58
- Tel
- 028-87925786 18010564218
- Fax
- 028-61777050
- vendi@cdforestchem.com
- Country
- China
- ProdList
- 1992
- Advantage
- 58
- Tel
- 010-80768286
- Country
- CHINA
- ProdList
- 90
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-25-58393656
- Fax
- +86-25-58393656
- sales@hengbeichem.cn
- Country
- China
- ProdList
- 6854
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- 0531-86092839 13153040268
- Fax
- QQ：2425815073
- 2425815073@qq.com
- Country
- China
- ProdList
- 265
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
View Lastest Price from 4-[(4-Methylpiperazin-1-yl)methyl]aniline manufacturers
- Product
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline 70261-82-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-09-01
- Product
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline 70261-82-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-30
- Product
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline 70261-82-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30