4-[(4-Methylpiperazin-1-yl)methyl]aniline
- Product Name
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline
- CAS No.
- 70261-82-4
- Chemical Name
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline
- Synonyms
- FN1501;AKOS BB-8955;1-methyl-4-(4-aminobenzyl)piperazine;1-(4-Aminobenzyl)-4-methylpiperazine;4-[(4-methyl-1-piperazinyl)methyl]aniline;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE;4-((4-methylpiperazin-1-yl)methyl)benzenamine;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYLAMINE;4-(4-Methylpiperazin-1-ylmethyl)phenylamine95%;4-[(4-Methyl-1-piperazinyl)methyl]-benzenamine
- CBNumber
- CB8464457
- Molecular Formula
- C12H19N3
- Formula Weight
- 205.3
- MOL File
- 70261-82-4.mol
4-[(4-Methylpiperazin-1-yl)methyl]aniline Property
- Melting point:
- 97-99oC
- Boiling point:
- 331.2±27.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 7.65±0.10(Predicted)
- form
- Solid
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M327310
- Product name
- 4-(4-Methylpiperazin-1-ylmethyl)phenylamine
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- COR0002706
- Product name
- 4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
- Product number
- COR0002706
- Product name
- 4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1548.26
- Updated
- 2021/12/16
- Product number
- 010950
- Product name
- 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine
- Packaging
- 500mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 010950
- Product name
- 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
4-[(4-Methylpiperazin-1-yl)methyl]aniline Chemical Properties,Usage,Production
Uses
4-(4-Methylpiperazin-1-ylmethyl)phenylamine is an intermediate used to prepare aminopyridopyrimidinones as tyrosine kinase inhibitors and anticancer agents. It is also used in the synthesis of piperazinyltrifluoromethylphenylquinolinylbenzonaphthyridinone derivatives with anticancer activities.
Synthesis
70261-81-3
70261-82-4
Step 2: Preparation of 4-(4-methylpiperazin-1-ylmethyl)aniline (F652-02) 1-Methyl-4-(4-nitrobenzyl)piperazine (F652-01, 4.67 g, 19.9 mmol), methanol (100 mL), zinc powder (6.5 g, 99.3 mmol), and ammonium chloride (4.3 g, 79.5 mmol) were added to a reaction vessel and heated and refluxed for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered through diatomaceous earth. The filtrate was distilled under reduced pressure to remove the solvent to give a solid product. Diethyl ether was added to the solid and the insoluble material was removed by filtration. The filtrate was distilled to remove the solvent to give 4-(4-methylpiperazin-1-ylmethyl)aniline (F652-02, white solid, 3.16 g, 77% yield). LC/MS (Method 6): m/z (ESI, POS): 206 [M + H]+; retention time: 1.15 min. 1H-NMR (400 MHz, DMSO-d6) δ 2.12 (s, 3H), 2.29 (bs, 8H), 3.23 (s, 2H), 4.93 (s, 2H), 6.49 (d, J = 8.4 Hz, 2H), 6.89 (d, J = 8.4 Hz, 2H).
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2917 - 2929
[2] Patent: WO2004/46120, 2004, A2. Location in patent: Page 173
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 15, p. 5738 - 5748
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 21, p. 8801 - 8815
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518
4-[(4-Methylpiperazin-1-yl)methyl]aniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(4-Methylpiperazin-1-yl)methyl]aniline Suppliers
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View Lastest Price from 4-[(4-Methylpiperazin-1-yl)methyl]aniline manufacturers
- Product
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline 70261-82-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-09-01
- Product
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline 70261-82-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-30
- Product
- 4-[(4-Methylpiperazin-1-yl)methyl]aniline 70261-82-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30