PP1

Product Name: PP1
CAS No.: 172889-26-8
Chemical Name: PP1
Synonyms: PP1;PPEN;CS-716;EI 275;AGL 1872;PP1 Base;PP1 USP/EP/BP;PP1, Free Base;PP1 (AGL 1872);AGL 1872,EI 275
CBNumber: CB8472133
Molecular Formula: C16H19N5
Formula Weight: 281.36
MOL File: 172889-26-8.mol

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PP1 Property

Melting point:: 205-207°C
storage temp.: room temp
solubility: DMSO: >20mg/mL
form: powder
color: white to off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0040
Product name: PP1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $211
Updated: 2024/03/01

Cayman Chemical

Product number: 14244
Product name: PP1 (Src Inhibitor)
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 14244
Product name: PP1 (Src Inhibitor)
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0040
Product name: PP1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $848
Updated: 2024/03/01

Cayman Chemical

Product number: 14244
Product name: PP1 (Src Inhibitor)
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

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PP1 Chemical Properties,Usage,Production

Description

PP1 (172889-26-8) is a potent and selective inhibitor of Src family tyrosine kinases. IC50=5 nM (p65lck), IC50=6 nM(P59fynT), IC50=170 nM (p60src). Cell permeable.

Chemical Properties

Off-White to Grey Solid

Uses

A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

Uses

PP1 has been used as:

an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Biological Activity

Potent inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.

Biochem/physiol Actions

PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.

in vitro

it was reported that pp1 specifically inhibited the expression and activity of lyn, a src family kinase, in rbl-2h3 cells. based on the immune-complex kinase assays in vitro, pp1 suppressed the activity of lyn at nanomolar levels without any effect on syk kinase activity. in contrast, phosphorylation of both syk and lyn kinases were both blocked in rbl cells. fcεri- and thy-1-mediated early and late activation events were also interrupted by pp1 in a similar mannar. moreover, pp1 was found to inhibited ret-derived oncoproteins with ic50 of 80 nm. ret/ptc3-transformed cells received pp1 treatment with a dose of 5 μm lost proliferative autonomy and showed morphological reversion. [2, 3]

in vivo

under in vivo conditions pp1 was suggested to suppress tyrosine phosphorylation and proliferation in t cells stimulated with anti-cd3 and mitogen. studies using mice tumor model also showed that pp1 upregulated the expression of the il-2 gene rather than the granulocyte macrophage colony-stimulating factor or the il-2 receptor genes. based on these, pp1 could be adopted as a useful agent to investigate the role of lck and fyn t cell activation. [2]

IC 50

a potent and selective inhibitor of src-family tyrosine kinases, with an ic50 of 5 and 6 nm respectively for p56lck and p59fynt.

storage

+4°C (desiccate)

References

1) Hanke et al. (1996), Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation; J. Biol. Chem., 271 695

PP1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PP1 Suppliers

Canada 1 China 137 Germany 3 India 1 Switzerland 1 United Kingdom 6 United States 27 Global 176

MedChemexpress LLC

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View Lastest Price from PP1 manufacturers

Career Henan Chemical Co

Product: PP1 172889-26-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 200kg
Release date: 2020-03-05

172889-26-8, PP1Related Search:

PP2 USP/EP/BP PP242 PP-360 PP 148 PP1 PP PP2B PP3 PP211 Cypermethrin EC 3.1.1.1 PP (31-36) MURINE CYTOMEGALOVIRUS PP 89 (170-174),MURINE CMV PP 89 (170-174) MURINE CYTOMEGALOVIRUS PP 89 (168-176),MURINE CMV PP 89 (168-176) (L)-HIV-TAT48-57-PP-JBD20 PP-3 PP2A PP1 ANALOG II,1 NM-PP1

1-(1,1-DIMETHYLETHYL)-1-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

PP1

PP1; PP 1; PP-1.

CS-716

PP1, Free Base

PP1 Base

EI 275

1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine

AGL 1872

4-AMINO-5-(4-METHYLPHENYL)-7-(T-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE

4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE

1-(TERT-BUTYL)-3-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

1-(TERT-BUTYL)-3-(4-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE

1-tert-Butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

PP1 (AGL 1872)

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(4-methylphenyl)-

AGL 1872,EI 275

4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine

1-tert-butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

PP1 (Src Inhibitor)

7-tert-Butyl-5-p-tolyl-6,7-dihydro-5H-pyrazolo[3,4-d]pyrimidin-4-amine

PP 1 (enzyme inhibitor)

Src Inhibitor, PP1

PP1;PP 1;PP-1;AGL 1872;EI 275

PP1 USP/EP/BP

1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine[AGL 1872

P-436 Poly(1-pentene)

Poly(1-propyl-1,2-ethanediyl)

Poly(1-propylethylene)

PPEN

PP1,AGL1872,EI275,EI-275,PP-1,Inhibitor,AGL-1872,PP 1,Src,inhibit,Apoptosis

PP 1, Src family tyrosine kinase inhibitor

PP1, 10 mM in DMSO

172889-26-8

C16H19N5

多肽抗原

小鼠抗人和大、小鼠磷酸酯酶-1 多克隆抗体

Inhibitors

Heterocyclic Compounds

Bases & Related Reagent

Heterocycles

Nucleotides

Protein Kinase Inhibitors and Activators

Protein Kinase