1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE

Product Name: 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE
CAS No.: 23794-15-2
Chemical Name: 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE
Synonyms: 1-(2-Chloropyridin-4-yl)ethan-1-one;4-ACETYL-2-CHLOROPYRIDINE;4-Acetyl-2-chloropyridine,97%;1-(2-Chloro-4-pyridyl)ethanone;1-(2-Chloro-4-pyridinyl)ethanone;1-(2-chloropyridine-4-yl)ethanone;1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE;1-(2-chloro-4-pyridinyl)-1-ethanone;Ethanone, 1-(2-chloro-4-pyridinyl)-;1-(2-Chloropyridin-4-yl)ethanone ,97%
CBNumber: CB8478610
Molecular Formula: C7H6ClNO
Formula Weight: 155.58
MOL File: 23794-15-2.mol

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1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE Property

Melting point:: 36.5 °C
Boiling point:: 270.2±25.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
Flash point:: >110℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: -1.55±0.10(Predicted)
color: Off white to brown

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT-HARMFUL
HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 734918
Product name: 4-Acetyl-2-chloropyridine
Purity: 97%
Packaging: 1g
Price: $119
Updated: 2023/06/20

TRC

Product number: C380655
Product name: 1-(2-Chloro-4-pyridinyl)ethanone
Packaging: 1g
Price: $165
Updated: 2021/12/16

TRC

Product number: C380655
Product name: 1-(2-Chloro-4-pyridinyl)ethanone
Packaging: 10g
Price: $855
Updated: 2021/12/16

Apolloscientific

Product number: OR8761
Product name: 4-Acetyl-2-chloropyridine
Packaging: 1g
Price: $18
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H17-5-X1
Product name: 4-Acetyl-2-chloropyridine
Packaging: 1g
Price: $20
Updated: 2021/12/16

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1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE Chemical Properties,Usage,Production

Uses

1-(2-Chloro-4-pyridinyl)ethanone is used for the synthesis of pyrimidine derivatives as hSMG-1 inhibitors in the treatment of cancer.

Synthesis

250263-39-9

75-16-1

23794-15-2

Step 2: Synthesis of 1-(2-chloropyridin-4-yl)ethanone To a solution of 2-chloro-N-methoxy-N-methylisonicotinamide (10.0 g, 50 mmol) in anhydrous tetrahydrofuran (50 mL) was slowly added 3M methylmagnesium bromide solution in tetrahydrofuran (50 mL, 150 mmol) at 0 °C, keeping stirring. After addition, the reaction mixture was gradually warmed to room temperature and stirring was continued overnight. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution, followed by extraction of the organic phase with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 1-(2-chloropyridin-4-yl)ethanone (7.5 g, 96% yield). Mass spectrometric analysis (ESI) showed m/z: 156.0 [M + H]+.

References

[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0106
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 21, p. 6636 - 6641,6
[3] Patent: WO2016/97351, 2016, A1. Location in patent: Page/Page column 11-12
[4] Patent: WO2004/78682, 2004, A2. Location in patent: Page 17-18
[5] Patent: US2012/225876, 2012, A1. Location in patent: Page/Page column 50

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE Preparation Products And Raw materials

Raw materials

Tetrahydrofuran 2-Chloro-4-cyanopyridine Methyl bromide Magnesium

Preparation Products

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1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE Suppliers

Belgium 1 Canada 1 China 121 Germany 3 India 5 United Kingdom 5 United States 21 Global 157

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View Lastest Price from 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE manufacturers

R&D Scientific Inc.

Product: 4-Acetyl-2-chloropyridine 23794-15-2
Price: US $2190.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-09-06

Dideu Industries Group Limited

Product: 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE 23794-15-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE 23794-15-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

23794-15-2, 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONERelated Search:

3-AMINO-2-CHLORO-ISONICOTINIC ACID METHYL ESTER 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE 1-(3-AMINO-2-CHLORO-PYRIDIN-4-YL)-ETHANONE 2-Chloro-5-acetylpyridine 4-Acetylpyridine 2-CHLORO-4-(5-CHLOROVALERYL)PYRIDINE (2-CHLORO-PYRIDIN-4-YL)-CYCLOHEXYL-METHANONE (2-CHLORO-PYRIDIN-4-YL)-CYCLOPENTYL-METHANONE (2-CHLORO-PYRIDIN-4-YL)-CYCLOPROPYL-METHANONE METHYL 2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(METHYLAMINO)BUT-2-ENOATE 2-CHLORO-4-VALERYLPYRIDINE 2-CHLORO-4-DODECANOYLPYRIDINE 2-CHLORO-4-HEPTANOYLPYRIDINE (2,6-Dichloro-4-pyridinyl)-2-thienyl-methanone 2-CHLORO-4-DECANOYLPYRIDINE (2-CHLORO-PYRIDIN-4-YL)-CYCLOBUTYL-METHANONE 2-CHLORO-4-PROPIONYLPYRIDINE 2-CHLORO-4-OCTANOYLPYRIDINE

1-(2-chloro-4-pyridinyl)ethanone(SALTDATA: FREE)

Ethanone, 1-(2-chloro-4-pyridinyl)-

1-(2-Chloro-4-pyridinyl)ethanone

1-(2-Chloro-4-pyridyl)ethanone

4-ACETYL-2-CHLOROPYRIDINE

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE

1-(2-chloro-4-pyridinyl)-1-ethanone

1-(2-Chloropyridin-4-yl)ethan-1-one

1-(2-chloropyridine-4-yl)ethanone

1-(2-Chloropyridin-4-yl)ethanone ,97%

4-Acetyl-2-chloropyridine,97%

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE ISO 9001：2015 REACH

23794-15-2

Pyridines

Pyridine series