2-Chloro-4-cyanopyridine

Product Name: 2-Chloro-4-cyanopyridine
CAS No.: 33252-30-1
Chemical Name: 2-Chloro-4-cyanopyridine
Synonyms: 2-CHLOROISONICOTINONITRILE;2-CHLOROPYRIDINE-4-CARBONITRILE;BUTTPARK 43\57-01;2-Chloro-4-cyanopyri;6-Chloro-4-cyanopyridine;2-CHLORO-4-CYANOPYRIDINE;oro-4-cyanopyridine, 98%;4-CYANO-2-CHLORO PYRIDINE;2-Chloro-4-cyanopyridine,97%;2-Chloro-4-cyanopyridine >
CBNumber: CB7673984
Molecular Formula: C6H3ClN2
Formula Weight: 138.55
MOL File: 33252-30-1.mol

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2-Chloro-4-cyanopyridine Property

Melting point:: 69-73 °C(lit.)
Boiling point:: 104-106°C 15mm
Density: 1.33±0.1 g/cm3(Predicted)
Flash point:: 104-106°C/15mm
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -1.60±0.10(Predicted)
color: White to Almost white
BRN: 113927
InChI: InChI=1S/C6H3ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H
InChIKey: QRXBTPFMCTXCRD-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C#N)=C1
CAS DataBase Reference: 33252-30-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-36/37
RIDADR: 3276
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 548227
Product name: 2-Chloro-4-pyridinecarbonitrile
Purity: 97%
Packaging: 25g
Price: $142
Updated: 2025/07/31

Sigma-Aldrich

Product number: 548227
Product name: 2-Chloro-4-pyridinecarbonitrile
Purity: 97%
Packaging: 5g
Price: $37
Updated: 2023/06/20

TCI Chemical

Product number: C1873
Product name: 2-Chloro-4-cyanopyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: C1873
Product name: 2-Chloro-4-cyanopyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $104
Updated: 2025/07/31

TRC

Product number: C380665
Product name: 2-Chloro-4-cyanopyridine
Packaging: 25g
Price: $165
Updated: 2021/12/16

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2-Chloro-4-cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

2-Chloro-4-cyanopyridine is an intermediate used to prepare pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). It is also used to synthesize pyridinyl-tetrazoles as scaffold to identify matrix MMP-13 inhibitors for treatment of osteoarthritis.

Materials Uses

2-Chloro-4-cyanopyridine is employed in the formulation of advanced materials, including polymers and coatings, offering improved durability and chemical resistance compared to similar compounds.

Synthesis

14906-59-3

33252-30-1

The general procedure for the synthesis of 2-chloro-4-cyanopyridine from 4-cyanopyridine N-oxide was as follows: 120 g of 4-cyanopyridine-N-oxide, 360 mL of 1,2-dichloroethane, and 183.6 g of phosphorochloridic acid were added sequentially in a 1000 mL three-necked reaction flask. After the reaction system was cooled to -2±2°C, 151.5 g of triethylamine was added slowly dropwise for a controlled dropwise time of 2 hours. After the dropwise addition, the reaction was continued at the same temperature with stirring for 2 hours. Upon completion of the reaction, the reaction solution was concentrated by reduced pressure distillation until no fractions flowed out. 240 mL of water was added to the concentrated solution and a large amount of solid was precipitated after thorough stirring. The solid was collected by filtration and the filter cake was washed with appropriate amount of water to obtain 117.5 g of white solid product 2-chloro-4-cyanopyridine.

References

[1] Tetrahedron Letters, 2001, vol. 42, # 39, p. 6815 - 6818
[2] Patent: CN104945383, 2017, B. Location in patent: Paragraph 0031; 0035; 0036

2-Chloro-4-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE

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2-Chloro-4-cyanopyridine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 3 China 327 Europe 4 France 4 Germany 4 India 32 Ireland 1 Italy 1 Japan 5 Jordan 1 Poland 1 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 3 United Kingdom 23 United States 60 Global 478

Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

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WEIFANG CYANOCHEM CO; LTD.

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View Lastest Price from 2-Chloro-4-cyanopyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4-cyanopyridine 33252-30-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-4-cyanopyridine 33252-30-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4-cyanopyridine 33252-30-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

33252-30-1, 2-Chloro-4-cyanopyridineRelated Search:

2-Chloro-4-picoline 2-Chloro-5-chloromethylpyridine ETHYL 2-CYANOACRYLATE 4-Cyanopyridine Pentachloropyridine Clopidol MCPA SODIUM Methylene dithiocyanate 2,6-Lutidine 2,6-Dichloroisonicotinonitrile 3-CHLORO-4-CYANOPYRIDINE,3-Chloro-4-cyanopyridine ,98% 2-Chloro-3-cyanopyridine 97%,2-CHLORO-3-CYANOPYRIDINE Difluorochloromethane 2,6-Dichloronicotinonitrile 2-CHLORO-3-CYANOPYRIDINE-4-BORONIC ACID 2-CHLORO-6-CYANOPYRIDINE,P-1002-Chloro-6-Cyanopyridine,6-CHLORO-2-CYANOPYRIDINE 4-CHLORO-2-CYANOPYRIDINE,2-Cyano-4-chloropyridine, 4-Chloro-2-cyanopyridine, 4-Chloropicolinonitrile 2-chloro-5-cyanopyridine

BUTTPARK 43\57-01

4-CYANO-2-CHLORO PYRIDINE

2-CHLORO-4-CYANOPYRIDINE

2-CHLORO-4-PYRIDINECARBONITRILE

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2-CHLORO-4-CYANOPYRIDINE 99+%

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2-Chloro-4-Cyano Pyridine 99%

2-Chloro-4-cyanopyridine ,98%

6-Chloro-4-cyanopyridine

2-Chloro-4-pyridinecarbonitrile,2-Chloro-4-cyanopyridine

2-Chloro-4-cyanopyri

2-Chloroisonicotinonitrile 2-Chloro-4-pyridinecarbonitrile

2-Chloro-4-cyanopyridine, 2-Chloropyridine-4-carbonitrile

2-4 - cyanopyridine chloride -

2-Chloro-4-cyanopyridine,97%

4-Pyridinecarbonitrile, 2-chloro-

2-Chloro-4-pyridinecarbonitrile 97%

2-Chloro-4-cyanopyridine &gt

oro-4-cyanopyridine, 98%

2-Chloro-4-cyanopyridine ISO 9001：2015 REACH

(2-Bromo-5-methoxy-53-methyl-phenyl)-methano

2-Chloro-4-cyanopyridine, 95%

33252-30-1

3252-30-1

1122-71-4

C7H4NCl

Building Blocks

Pyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines, Pyrimidines, Purines and Pteredines

Halides

Pyridine

Chloropyridines

Halopyridines

blocks

Carboxes

Pyridines

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles

bc0001