3-Chloro-4-cyanopyridine

Product Name: 3-Chloro-4-cyanopyridine
CAS No.: 68325-15-5
Chemical Name: 3-Chloro-4-cyanopyridine
Synonyms: 3-CHLORO-ISONICOTINONITRILE;3-Chloro-4-cyanopyri;3-chloro-4-cynopyridine;3-CHLORO-4-CYANOPYRIDINE;3- chloro-4-cyanpyridine;3-Chloro-4-cyanopyridine ,98%;3-Chloropyridin-4-carbonitrile;3-CHLOROPYRIDINE-4-CARBONITRILE;3-Chloro-4-pyridinecarbonitrile;4-Pyridinecarbonitrile, 3-chloro-
CBNumber: CB2209702
Molecular Formula: C6H3ClN2
Formula Weight: 138.55
MOL File: 68325-15-5.mol

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3-Chloro-4-cyanopyridine Property

Melting point:: 71-73°C
Boiling point:: 233.3±20.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane, Ethyl Acetate, Methanol
form: Solid
pka: -0.41±0.18(Predicted)
color: Pale Yellow
InChI: InChI=1S/C6H3ClN2/c7-6-4-9-2-1-5(6)3-8/h1-2,4H
InChIKey: JLLJPPBGJVCFGG-UHFFFAOYSA-N
SMILES: C1=NC=CC(C#N)=C1Cl
CAS DataBase Reference: 68325-15-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37
RIDADR: UN3439
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 792667
Product name: 3-Chloropyridine-4-carbonitrile
Purity: 97%
Packaging: 500mg
Price: $140
Updated: 2023/01/07

TCI Chemical

Product number: C2998
Product name: 3-Chloro-4-cyanopyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: C2998
Product name: 3-Chloro-4-cyanopyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $164
Updated: 2025/07/31

Usbiological

Product number: C4978-45
Product name: 3-Chloro-4-cyanopyridine
Packaging: 100mg
Price: $403
Updated: 2021/12/16

TRC

Product number: C365100
Product name: 3-Chloro-4-cyanopyridine
Packaging: 500mg
Price: $495
Updated: 2021/12/16

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3-Chloro-4-cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.

Synthesis

100-48-1

68325-15-5

The general procedure for the synthesis of 3-chloro-4-cyanopyridine from 4-cyanopyridine was as follows: to a stirred solution of 2,2,6,6-tetramethylpiperidine (17.16 mL, 100.854 mmol) in tetrahydrofuran (THF, 100 mL) at -30 °C was slowly added n-butyllithium (n-BuLi, 2.17 M, 44.26 mL, 96.052 mmol). The reaction mixture was stirred at 25 °C for 15 min before being cooled to -78 °C and a solution of 4-cyanopyridine (5 g, 48.026 mmol) in THF (40 mL) was added slowly and dropwise. After continued stirring at -78 °C for 30 min, a THF (50 mL) solution of hexaethyl ethane (23.87 g, 100.854 mmol) was added. The resulting mixture was stirred at -78 °C for 30 min, followed by quenching the reaction with saturated ammonium chloride (NH4Cl) solution. Water (100 mL) was added to the reaction mixture and extracted with ethyl acetate (4 x 300 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 5% ethyl acetate-hexane as eluent to yield 3-chloropyridine-4-carbonitrile (3.5 g, 25.26±1 mmol, 53% yield) as a light-white solid.The GC-MS analysis showed the molecular ion peak to be 138 m/z. The molecular ions were analyzed by GC-MS.

References

[1] Tetrahedron, 2006, vol. 62, # 25, p. 5862 - 5867
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10118 - 10129
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 182; 183
[4] Tetrahedron Letters, 2005, vol. 46, # 1, p. 135 - 137
[5] Journal of the American Chemical Society, 2013, vol. 135, # 24, p. 9213 - 9219

3-Chloro-4-cyanopyridine Preparation Products And Raw materials

Raw materials

Sodium perborate tetrahydrate 4-Cyanopyridine Hydrogen peroxide Phosphorus oxitrichloride Phosphorus pentachloride Sodium bicarbonate Acetic acid

Preparation Products

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3-Chloro-4-cyanopyridine Suppliers

Americas 1 Canada 2 China 214 Europe 2 France 1 Germany 4 India 9 Japan 1 South Korea 1 United Kingdom 7 United States 31 Global 273

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View Lastest Price from 3-Chloro-4-cyanopyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Chloro-4-cyanopyridine 68325-15-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Career Henan Chemical Co

Product: 3-Chloro-4-cyanopyridine 68325-15-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

68325-15-5, 3-Chloro-4-cyanopyridineRelated Search:

2-Chloro-5-chloromethylpyridine 2,3,5,6-Tetrachloropyridine 2-Chloropyridine-N-oxide 4-Cyanopyridine Clopidol pyridinium Chlorochromate Difluorochloromethane 2-CHLORO-4-CYANOPYRIDINE,2-CHLORO-4-CYANOPYRIDINE 2-CHLORO-ISONICOTINONITRILE,2-CHLORO-4-CYANOPYRIDINE 99+%,2-Chloro-4-cyanopyridine ,98% 5-Bromo-2-chloro-3-cyanopyridine 3,5-DICHLORO-4-PYRIDINECARBONITRILE 2-AMINO-3-CHLORO-5-CYANOPYRIDINE, 95+% 3,5-Dichloro-2-cyanopyridine 2-CYANO-3-CHLORO PYRIDINE / 3-CHLORO-2-CYANOPYRIDINE,3-Chloro-2-cyanopyridine ,95%,3-CHLORO-2-CYANOPYRIDINE 2,6-Dichloroisonicotinonitrile P-1002-Chloro-6-Cyanopyridine,6-CHLORO-2-CYANOPYRIDINE,2-CHLORO-6-CYANOPYRIDINE 2-chloro-5-cyanopyridine 2-Cyano-4-chloropyridine, 4-Chloro-2-cyanopyridine, 4-Chloropicolinonitrile,4-CHLORO-2-CYANOPYRIDINE 2,3,5,6-TETRACHLOROISONICOTINONITRILE

3-CHLORO-4-CYANOPYRIDINE

3-CHLORO-ISONICOTINONITRILE

3-CHLOROPYRIDINE-4-CARBONITRILE

3-chloro-4-cynopyridine

4-Pyridinecarbonitrile,3-chloro-(9CI)

3-Chloro-4-cyanopyridine ,98%

3-Chloro-4-pyridinecarbonitrile

3-Chloro-4-cyanopyri

3-Chloro-4-cyanopyridine, 3-Chloropyridine-4-carbonitrile

3-Chloropyridine-4-carbonitrile 97%

3-Chloro-4-Cyanopyridine(WX683516)

3- chloro-4-cyanpyridine

4-Pyridinecarbonitrile, 3-chloro-

3-Chloro-4-cyanopyridine ISO 9001：2015 REACH

3-Chloropyridin-4-carbonitrile

68325-15-5

68325-15-3

C6H3ClN

Amines

NITRILE

Halides

Pyridines

Heterocyclic Compounds

Heterocycle-Pyridine series

Aromatics

Heterocycles

Pyridine