2-Chloro-5-acetylpyridine

Application

Product Name: 2-Chloro-5-acetylpyridine
CAS No.: 55676-22-7
Chemical Name: 2-Chloro-5-acetylpyridine
Synonyms: 1-(6-CHLOROPYRIDIN-3-YL)ETHANONE;1-(6-Chloropyridin-3-yl)ethan-1-one;1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE;3-Acetyl-6-chloropyridine;5-Acetyl-2-chloropyridine;6-CHLORO-3-ACETYLPYRIDINE;2-CHLORO-5-ACETYLPYRIDINE;5-Acetyl-2-chloropyridine >1-(6-Chlorpyridin-3-yl)ethanon;1-(6-chloro-3-pyridinyl)ethanone
CBNumber: CB1354254
Molecular Formula: C7H6ClNO
Formula Weight: 155.58
MOL File: 55676-22-7.mol

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2-Chloro-5-acetylpyridine Property

Melting point:: 98 °C
Boiling point:: 280.5±20.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -2.14±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C7H6ClNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3
InChIKey: UXSNZYGTQTXRAD-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(Cl)N=C1)C
CAS DataBase Reference: 55676-22-7

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: WGK 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 2933399990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2796
Product name: 5-Acetyl-2-chloropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: A2796
Product name: 5-Acetyl-2-chloropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $122
Updated: 2025/07/31

TRC

Product number: C596183
Product name: 1-(6-Chloropyridin-3-yl)ethanone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C596183
Product name: 1-(6-Chloropyridin-3-yl)ethanone
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 046735
Product name: 1-(6-Chloro-3-pyridinyl)-1-ethanone
Purity: 95+%
Packaging: 1g
Price: $18
Updated: 2021/12/16

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2-Chloro-5-acetylpyridine Chemical Properties,Usage,Production

Application

2-Chloro-5-acetylpyridine is also used industrially as a denaturant and dyeing aid.

Synthesis

923034-23-5

55676-22-7

Step 3 Synthesis of 1-(6-chloropyridin-3-yl)ethanone: Dimethyl 2-(6-chloronicotinoyl)malonate (89.8 g, 331 mmol) was dissolved in a solvent mixture of DMSO (445 mL) and water (11 mL), and the reaction was heated for 2.5 hr at 130 °C. After the reaction was completed, the reaction mixture was cooled and poured into H2O/ice (300 mL). The aqueous phase was extracted with EtOAc (4 x 150 mL). The organic phases were combined, washed with brine, dried and concentrated under reduced pressure. The residue was recrystallized by 60% ethanol-water solution to afford the target compound 1-(6-chloropyridin-3-yl)ethanone in a yield of 16.5 g (32% yield) as a yellow solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Tetrahedron, 1992, vol. 48, # 42, p. 9233 - 9236
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 3041 - 3044

2-Chloro-5-acetylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-acetylpyridine Suppliers

Americas 1 Belgium 2 China 240 Europe 1 France 1 Germany 4 India 14 Japan 1 South Korea 1 Switzerland 1 United Kingdom 7 United States 26 Global 299

Zhejiang Karry Pharmachem Co., Ltd.

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Energy Chemical

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View Lastest Price from 2-Chloro-5-acetylpyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-5-acetylpyridine 55676-22-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Nanjing Fred Technology Co., Ltd

Product: 2-Chloro-5-acetylpyridine 55676-22-7
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99%
Supply Ability: 5 ton
Release date: 2023-11-29

LY Global chemicals co.,ltd .

Product: 2-Chloro-5-acetylpyridine 55676-22-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2023-03-27

55676-22-7, 2-Chloro-5-acetylpyridineRelated Search:

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1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE

1-(6-CHLOROPYRIDIN-3-YL)ETHANONE

1-(6-chloro-3-pyridinyl)ethanone

6-CHLORO-3-ACETYLPYRIDINE

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1-(6-Chloropyridin-3-yl)ethan-1-one

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Ethanone, 1-(6-chloro-3-pyridinyl)-

1-(6-CHLORO-3-PYRIDINYL)-1-ETHANON

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2-CHLORO-5-ACETYLPYRIDINE

5-Acetyl-2-chloropyridine &gt

2-Chloro-5-acetylpyridine ISO 9001：2015 REACH

1-(6-Chlorpyridin-3-yl)ethanon

55676-22-7

152356-57-6

Heterocycle-Pyridine series