2-Chloro-5-acetylpyridine
Application- Product Name
- 2-Chloro-5-acetylpyridine
- CAS No.
- 55676-22-7
- Chemical Name
- 2-Chloro-5-acetylpyridine
- Synonyms
- 1-(6-CHLOROPYRIDIN-3-YL)ETHANONE;1-(6-Chloropyridin-3-yl)ethan-1-one;1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE;3-Acetyl-6-chloropyridine;5-Acetyl-2-chloropyridine;6-CHLORO-3-ACETYLPYRIDINE;2-CHLORO-5-ACETYLPYRIDINE;5-Acetyl-2-chloropyridine >1-(6-Chlorpyridin-3-yl)ethanon;1-(6-chloro-3-pyridinyl)ethanone
- CBNumber
- CB1354254
- Molecular Formula
- C7H6ClNO
- Formula Weight
- 155.58
- MOL File
- 55676-22-7.mol
2-Chloro-5-acetylpyridine Property
- Melting point:
- 98 °C
- Boiling point:
- 280.5±20.0 °C(Predicted)
- Density
- 1.233±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- -2.14±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C7H6ClNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3
- InChIKey
- UXSNZYGTQTXRAD-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=C(Cl)N=C1)C
- CAS DataBase Reference
- 55676-22-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2796
- Product name
- 5-Acetyl-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- A2796
- Product name
- 5-Acetyl-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- C596183
- Product name
- 1-(6-Chloropyridin-3-yl)ethanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C596183
- Product name
- 1-(6-Chloropyridin-3-yl)ethanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 046735
- Product name
- 1-(6-Chloro-3-pyridinyl)-1-ethanone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
2-Chloro-5-acetylpyridine Chemical Properties,Usage,Production
Application
2-Chloro-5-acetylpyridine is also used industrially as a denaturant and dyeing aid.
Synthesis
923034-23-5
55676-22-7
Step 3 Synthesis of 1-(6-chloropyridin-3-yl)ethanone: Dimethyl 2-(6-chloronicotinoyl)malonate (89.8 g, 331 mmol) was dissolved in a solvent mixture of DMSO (445 mL) and water (11 mL), and the reaction was heated for 2.5 hr at 130 °C. After the reaction was completed, the reaction mixture was cooled and poured into H2O/ice (300 mL). The aqueous phase was extracted with EtOAc (4 x 150 mL). The organic phases were combined, washed with brine, dried and concentrated under reduced pressure. The residue was recrystallized by 60% ethanol-water solution to afford the target compound 1-(6-chloropyridin-3-yl)ethanone in a yield of 16.5 g (32% yield) as a yellow solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Tetrahedron, 1992, vol. 48, # 42, p. 9233 - 9236
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 3041 - 3044
2-Chloro-5-acetylpyridine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Chloro-5-acetylpyridine manufacturers
- Product
- 2-Chloro-5-acetylpyridine 55676-22-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2-Chloro-5-acetylpyridine 55676-22-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99%
- Supply Ability
- 5 ton
- Release date
- 2023-11-29
- Product
- 2-Chloro-5-acetylpyridine 55676-22-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2023-03-27