Protein degrader 1 (TFA)

Product Name: Protein degrader 1 (TFA)
CAS No.: 1631137-51-3
Chemical Name: Protein degrader 1 (TFA)
Synonyms: S)-AHPC TFA;VH032-NH2 TFA;(S,R,S)-AHPC TFA;VHL ligand 1 (TFA);E3 ligase Ligand 6;Protein degrader 1 (TFA);(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate;VH032-NH2,Inhibitor,inhibit,E3 ligase-recruiting Moiety,Ligands for E3 Ligase,(S,R,S)-AHPC,(S,R,S)AHPC TFA,VHL ligand 1,VHL ligand1,VHL ligand-1,(S,R,S) AHPC TFA
CBNumber: CB84796684
Molecular Formula: C24H31F3N4O5S
Formula Weight: 544.59
MOL File: 1631137-51-3.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC26127
Product name: VHLligand1(TFA)
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC26127
Product name: VHLligand1(TFA)
Purity: >98%
Packaging: 1g
Price: $2700
Updated: 2021/12/16

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Protein degrader 1 (TFA) Chemical Properties,Usage,Production

Description

VHL-7526, also known as Protein degrader 1, is a protein degrader and is a small molecule ligand for VHL

Uses

(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC 50

VHL

References

[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442

Protein degrader 1 (TFA) Preparation Products And Raw materials

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Preparation Products

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1631137-51-3, Protein degrader 1 (TFA)Related Search:

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Protein degrader 1 (TFA)

E3 ligase Ligand 6

VHL ligand 1 (TFA)

(S,R,S)-AHPC TFA

VH032-NH2 TFA

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate

S)-AHPC TFA

VH032-NH2,Inhibitor,inhibit,E3 ligase-recruiting Moiety,Ligands for E3 Ligase,(S,R,S)-AHPC,(S,R,S)AHPC TFA,VHL ligand 1,VHL ligand1,VHL ligand-1,(S,R,S) AHPC TFA

1631137-51-3