ChemicalBook > CAS DataBase List > AZD-7648

AZD-7648

Product Name
AZD-7648
CAS No.
2230820-11-6
Chemical Name
AZD-7648
Synonyms
AZD7640;CPD2810;AZD-7648;AZD-7648, 10 mM in DMSO;AZD-7648;AZD 7648;AZD7648;7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one;7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-;DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinositide 3-kinase,AZD-7648,Ataxia telangiectasia mutated,antitumor,ATM and RAD3 related,ATM/ATR,AZD 7648,DNA-PK
CBNumber
CB84844134
Molecular Formula
C18H20N8O2
Formula Weight
380.4
MOL File
2230820-11-6.mol
More
Less

AZD-7648 Property

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C)
form 
A crystalline solid
pka
3.53±0.20(Predicted)
color 
Off-white to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
25mg
Price
$704
Updated
2024/03/01
Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
10mg
Price
$301
Updated
2024/03/01
ChemScene
Product number
CS-0091859
Product name
AZD-7648
Purity
99.89%
Packaging
50mg
Price
$400
Updated
2021/12/16
More
Less

AZD-7648 Chemical Properties,Usage,Production

Uses

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity in non small cell lung cancer.

in vivo

AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression[1].

Animal Model:Nude mice, A549 xenografts and NCI-H1299 xenografts[1]
Dosage:100 mg/kg
Administration:Oral administration, once daily for 5 days
Result:Induced tumour growth inhibition in combination with IR in A549 xenografts and induced tumour regression in combination with IR in NCI-H1299 xenografts.

IC 50

PI3Kγ: 1.37 μM (IC50); ATM: 17.93 μM (IC50); DNA-PKcs: 91.3 nM (IC50)

storage

Store at -20°C

AZD-7648 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AZD-7648 Suppliers

China 91 United States 6 Global 97
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32239
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38648
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
More
Less

View Lastest Price from AZD-7648 manufacturers

Career Henan Chemical Co
Product
AZD-7648 2230820-11-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10
Career Henan Chemical Co
Product
AZD-7648 2230820-11-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

2230820-11-6, AZD-7648Related Search:

AZD-5672 AZD0364 CCR1 antagonist AZD5153 AZD-8055 AZD-0284 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

  • CPD2810
  • AZD-7648
  • AZD-7648;AZD 7648;AZD7648
  • 7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one
  • AZD7640
  • 8H-Purin-8-one, 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-
  • 7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one
  • DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinositide 3-kinase,AZD-7648,Ataxia telangiectasia mutated,antitumor,ATM and RAD3 related,ATM/ATR,AZD 7648,DNA-PK
  • AZD-7648, 10 mM in DMSO
  • 2230820-11-6
  • APIs
  • api