PF-06873600
- Product Name
- PF-06873600
- CAS No.
- 2185857-97-8
- Chemical Name
- PF-06873600
- Synonyms
- Ebvaciclib;PF-06873600;PF06873600,PF 06873600;Ebvaciclib (PF-06873600);6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）
- CBNumber
- CB84918288
- Molecular Formula
- C20H27F2N5O4S
- Formula Weight
- 471.52
- MOL File
- 2185857-97-8.mol
PF-06873600 Property
- Boiling point:
- 634.0±65.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:15.0(Max Conc. mg/mL);31.81(Max Conc. mM)
- form
- A solid
- pka
- 14.69±0.40(Predicted)
- InChIKey
- QIEKHLDZKRQLLN-FOIQADDNSA-N
- SMILES
- C1(NC2CCN(S(C)(=O)=O)CC2)=NC=C2C=C(C(F)F)C(=O)N([C@@H]3CCC[C@]3(O)C)C2=N1
N-Bromosuccinimide Price
- Product number
- CS-0078633
- Product name
- PF-06873600
- Purity
- 99.98%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0078633
- Product name
- PF-06873600
- Purity
- 99.98%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0078633
- Product name
- PF-06873600
- Purity
- 99.98%
- Packaging
- 25mg
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- CS-0078633
- Product name
- PF-06873600
- Purity
- 99.98%
- Packaging
- 50mg
- Price
- $2750
- Updated
- 2021/12/16
- Product number
- CS-0078633
- Product name
- PF-06873600
- Purity
- 99.98%
- Packaging
- 100mg
- Price
- $3950
- Updated
- 2021/12/16
PF-06873600 Chemical Properties,Usage,Production
Description
PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively. It also blocks the phosphorylation of retinoblastoma protein (RB1) and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.
Mechanism of action
PF-06873600 is taken as a tablet by mouth. PF-06873600 is a cancer growth blocker targeting specific proteins called Cyclin-Dependent Kinase 2, 4, and 6 (CDK2/4/6). It works by stopping or preventing the action of these proteins, which stimulate cancer cells to grow and divide. PF-06873600 selectively targets, binds to, and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are essential regulators of cell cycle progression and cellular proliferation are frequently overexpressed in tumour cells.
PF-06873600 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06873600 Suppliers
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
- Country
- China
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- 2613
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- 021-52996696，15000506266 15000506266
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- +86-21-52996696
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- China
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- 17764003753
- Fax
- 13669031409
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- Country
- China
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- 55
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
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- 188
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- 55
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
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- 9952
- Advantage
- 58
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- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
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- 021-58170097
- info@topbiochem.com
- Country
- China
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- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
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- Tel
- 19983777532
- Fax
- -
- pharmabridge@163.com
- Country
- China
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- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1845
- Advantage
- 55
View Lastest Price from PF-06873600 manufacturers
- Product
- PF-06873600 2185857-97-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 100mg
- Purity
- 95%
- Supply Ability
- 1kg
- Release date
- 2023-05-25