PF-06873600

Product Name: PF-06873600
CAS No.: 2185857-97-8
Chemical Name: PF-06873600
Synonyms: Ebvaciclib;PF-06873600;PF06873600,PF 06873600;Ebvaciclib (PF-06873600);PF-06873600, 10 mM in DMSO;6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）
CBNumber: CB84918288
Molecular Formula: C20H27F2N5O4S
Formula Weight: 471.52
MOL File: 2185857-97-8.mol

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PF-06873600 Property

Boiling point:: 634.0±65.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:15.0(Max Conc. mg/mL);31.81(Max Conc. mM)
form: A solid
pka: 14.69±0.40(Predicted)
color: White to light yellow
InChIKey: QIEKHLDZKRQLLN-FOIQADDNSA-N
SMILES: C1(NC2CCN(S(C)(=O)=O)CC2)=NC=C2C=C(C(F)F)C(=O)N([C@@H]3CCC[C@]3(O)C)C2=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0078633
Product name: PF-06873600
Purity: 99.98%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0078633
Product name: PF-06873600
Purity: 99.98%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0078633
Product name: PF-06873600
Purity: 99.98%
Packaging: 25mg
Price: $1750
Updated: 2021/12/16

ChemScene

Product number: CS-0078633
Product name: PF-06873600
Purity: 99.98%
Packaging: 50mg
Price: $2750
Updated: 2021/12/16

ChemScene

Product number: CS-0078633
Product name: PF-06873600
Purity: 99.98%
Packaging: 100mg
Price: $3950
Updated: 2021/12/16

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PF-06873600 Chemical Properties,Usage,Production

Description

PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively. It also blocks the phosphorylation of retinoblastoma protein (RB1) and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.

Uses

PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity[1][2].

Mechanism of action

PF-06873600 is taken as a tablet by mouth. PF-06873600 is a cancer growth blocker targeting specific proteins called Cyclin-Dependent Kinase 2, 4, and 6 (CDK2/4/6). It works by stopping or preventing the action of these proteins, which stimulate cancer cells to grow and divide. PF-06873600 selectively targets, binds to, and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are essential regulators of cell cycle progression and cellular proliferation are frequently overexpressed in tumour cells.

IC 50

CDK2: 0.09 nM (Ki); CDK4: 0.13 nM (Ki); CDK6: 0.16 nM (Ki)

References

[1] US 2018/0044344 A1.
[2] NCI Drug Dictionary

PF-06873600 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06873600 Suppliers

China 91 United States 4 Global 95

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
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Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
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Shanghai Topbiochem Technology Co., Ltd

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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
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Shanghai PharmaPartner Co., Ltd.

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Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Country: China
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View Lastest Price from PF-06873600 manufacturers

Jiangsu Nata Opto-electronic Material Co.,Ltd.

Product: PF-06873600 2185857-97-8
Price: US $0.00-0.00/mg
Min. Order: 100mg
Purity: 95%
Supply Ability: 1kg
Release date: 2023-05-25

2185857-97-8, PF-06873600Related Search:

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PF-06873600

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）

6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Ebvaciclib (PF-06873600)

Ebvaciclib

PF06873600,PF 06873600

PF-06873600, 10 mM in DMSO

2185857-97-8

C20H27F2N5O4S