TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

Product Name: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
CAS No.: 252881-74-6
Chemical Name: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
Synonyms: tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate;NH2-PEG3-C2-Boc;tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate;H2N-PEG3-tBu;NH2-PEG3-TBA;Amino-PEG3-COOtBu;NH2-PEG3-C2-COOtBu;NH2-PEG3-CH2CH2COtBu;NH2-PEG3-CH2CH2COOtBu;H2N-PEG3-CH2CH2COOtBu
CBNumber: CB8497770
Molecular Formula: C13H27NO5
Formula Weight: 277.36
MOL File: 252881-74-6.mol

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TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Property

Boiling point:: 358.5±27.0 °C(Predicted)
Density: 1.029±0.06 g/cm3(Predicted)
Flash point:: 169.7 °C
storage temp.: -20°C
form: oil
pka: 8.74±0.10(Predicted)
color: Clear
InChI: InChI=1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3
InChIKey: CWFSAZJIJBTKRC-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCN

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
F: 10-34
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 83060
Product name: tert-Butyl 12-amino-4,7,10-trioxadodecanoate
Purity: technical,≥80%(T)
Packaging: 1g
Price: $180.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 83060
Product name: tert-Butyl 12-amino-4,7,10-trioxadodecanoate
Purity: technical,≥80%(T)
Packaging: 5G
Price: $714
Updated: 2025/07/31

TCI Chemical

Product number: B5586
Product name: Amino-PEG3-acid tert-Butyl Ester
Packaging: 1G
Price: $239
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0124663
Product name: TERT-BUTYL 12-AMINO-4,7,10-TRIOXADODECANOATE
Purity: 95.00%
Packaging: 5G
Price: $1391.03
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0124663
Product name: TERT-BUTYL 12-AMINO-4,7,10-TRIOXADODECANOATE
Purity: 95.00%
Packaging: 1G
Price: $756.76
Updated: 2021/12/16

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TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Chemical Properties,Usage,Production

Description

Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:

Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
Synthesis of polycationic adamantane-based dendrons for cell imaging.
Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

reaction suitability

reagent type: cross-linking reagent

Synthesis

252881-73-5

252881-74-6

The general procedure for the synthesis of tert-butyl 12-amino-4,7,10-trioxa-dodecanoate from tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propionate was as follows: Raney-Ni (7.5 g, suspended in water) was washed sequentially with water (three times) and isopropanol (three times), and was subsequently mixed with tert-butyl 3-(2-(2-(2- azidoethoxy)ethoxy ) ethoxy)propionic acid tert-butyl ester (5.0 g, 16.5 mmol) in isopropanol. The reaction mixture was stirred at room temperature under hydrogen atmosphere for 16 hours. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the pad was washed with isopropanol. The filtrate was concentrated and purified by column chromatography (eluent: 5-25% methanol/dichloromethane) to afford the light yellow oily product tert-butyl 12-amino-4,7,10-trioxa-dodecanoate (2.60 g, 57% yield). Mass spectrometry (ESI) m/z calculated value C13H28NO5 [M+H]+ 279.19; measured value: 279.19.

IC 50

PEGs

References

[1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
[2] Journal of the American Chemical Society, 2018, vol. 140, # 38, p. 12189 - 12199
[3] Patent: WO2016/59622, 2016, A2. Location in patent: Page/Page column 102-103
[4] Patent: WO2017/46658, 2017, A1. Location in patent: Page/Page column 148
[5] Patent: WO2018/86139, 2018, A1. Location in patent: Page/Page column 151

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Suppliers

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View Lastest Price from TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA manufacturers

LAURENT

Product: NH2-PEG3-CH2CH2COOtBu 252881-74-6
Price: US $29.93/g
Min. Order: 10g
Purity: 97%
Supply Ability: 300kg
Release date: 2025-11-18

LAURENT

Product: NH2-PEG3-CH2CH2COOtBu 252881-74-6
Price: US $923.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-18

LAURENT

Product: NH2-PEG3-CH2CH2COOtBu 252881-74-6
Price: US $923.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-18

252881-74-6, TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECARelated Search:

H2N-PEG3-CH2COOtBu N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE PENTAETHYLENE GLYCOL MPEG7-CH2CH2COOH 2,5,8,11-TETRAOXATRIDECANE-13-THIOL 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol MPEG4-CH2CH2COOH FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID Biotin-PEG3-propionic acid HO-PEG16-OH Decaethylene glycol alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol) FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID FMOC-GAMMA-ABU-OH 1-Azidohexaethylene Glycol alpha-aMine-oMega-propionic acid dodecaethylene glycol Biotin-PEG4-N3 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL

[(+)-BIOTIN-PEG12-NHS ESTER]

H2N-PEG3-CH2CH2-t-butylester

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

Amino-PEG3-COOtBu

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

H2N-PEG3-tBu

H2N-PEG3-CH2CH2COOtBu

tert-Butyl 12-aMino-4,7,10-trioxa-dodec

tert-butyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate

3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester

NH2-PEG3-CH2CH2COOtBu

tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate

Propanoic acid,3-[2-[2-(2-aMinoethoxy)ethoxy]ethoxy]-, 1,1-diMethylethyl ester

tert-Butyl 12-amino-4,7,10-trioxadodecanoate technical, >=80% (T)

Amino-PEG3-tert-butyl ester

NH2-PEG3-C2-Boc

H2N-(CH2CH2O)3-CH2CH2COOt-Bu

Amino-PEG3-acid tert-Butyl Ester

Amino-PEG3-t-Bu Ester

H2N-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

NH2-PEG3-C2-COOtBu

12-Amino-4,7,10-Trioxdodecanoic acid tert-butyl ester

<i>tert</i>-Butyl 12-amino-4,7,10-trioxadodecanoate

NH2-PEG3-TBA

NH2-PEG3-CH2CH2COtBu

252881-74-6

C13H27NO5

PEG-COOtBu

peg