5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE

Product Name: 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE
CAS No.: 35899-54-8
Chemical Name: 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE
Synonyms: SIBA;SIBA, 10 mM in DMSO;5'-Isobutylthioadenosine;5'-S-Isobutylthioadenosine;5'-S-Isobutyl-5'-deoxyadenosine;5''-Deoxy-5''-S-isobutyladenosine;5'-Deoxy-5'-isobutylthioadenosine;5'-Isobutylthio-5'-deoxyadenosine;5'-Isobutylthio-5'-deoxyadenosine;5’-deoxy-5’-s-isobutylthioadenosine
CBNumber: CB8503653
Molecular Formula: C14H21N5O3S
Formula Weight: 339.41
MOL File: 35899-54-8.mol

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5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Property

Boiling point:: 631.2±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO : ≥ 100 mg/mL (294.63 mM)
pka: 13.13±0.70(Predicted)
form: Solid
color: Off-white to gray

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5062
Product name: SIBA
Purity: 99.42%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015019
Product name: 5'-DEOXY-5'-S-ISOBUTYLTHIOADENOSINE
Purity: 95.00%
Packaging: 5MG
Price: $497.97
Updated: 2021/12/16

ChemScene

Product number: CS-5062
Product name: SIBA
Purity: 99.42%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611715
Product name: SIBA
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

ChemScene

Product number: CS-5062
Product name: SIBA
Purity: 99.42%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Chemical Properties,Usage,Production

Uses

SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH.html" class="link-product" target="_blank">SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].

in vivo

SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo^[1].
SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo^[1].

Animal Model:	C57BL/6 female mice (4-8 weeks old)^[1].
Dosage:	150 mg/kg
Administration:	Intraperitoneal injection; twice weekly for 3 weeks.
Result:	Significantly reduced the median number of lung metastases.

Animal Model:	Adult syngeneic Wistar AG rats (8-week-old; subcutaneously grafted with RMS-J1 cells)^[1].
Dosage:	15 mg/kg
Administration:	Intraperitoneal injection; thrice weekly for 4 weeks.
Result:	Inhibited in vivo metastatic spread of RMS-J1 cells, and showed median numbers of lung metastatic nodules was 26.

IC 50

Plasmodium; HSV-1

References

[1] F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. DOI:10.1007/BF01580402
[2] B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. DOI:10.1128/JVI.22.1.160-167.1977
[3] Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9. DOI:10.1042/bj2040853

5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Suppliers

China 33 Switzerland 1 United States 9 Global 43

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35899-54-8, 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINERelated Search:

Dideoxyinosine 2'-Deoxyadenosine monohydrate Cyclic AMP Dideoxyadenosine 5'-DEOXYADENOSINE ADP DL-BUTHIONINE-[S,R]-SULFOXIMINE Adenosine 5'-DEOXY-5'-METHYLTHIOADENOSINE (S)-1-MERCAPTOGLYCEROL 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE ETHYL ISOBUTYL SULFIDE ISO-BUTYL PROPYL SULFIDE 2-(ISOBUTYLTHIO)ETHANOL 3-ETHYLTHIO-1,2-PROPANEDIOL,97%

5'-Isobutylthioadenosine

5'-ISOBUTYLTHIOADENOSINE;5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE

5'-Deoxy-5'-isobutylthioadenosine

5’-deoxy-5’-s-isobutylthioadenosine

5'-S-(2-Methylpropyl)-5'-thioadenosine

SIBA

5'-S-Isobutyl-5'-deoxyadenosine

5'-S-Isobutylthioadenosine

Adenosine, 5'-S-(2-methylpropyl)-5'-thio-

5''-Deoxy-5''-S-isobutyladenosine

5μ-Deoxy-5μ-S-isobutylthioadenosine, 5μ-S-(2-Methylpropyl)-5μ-thioadenosine

chick embryo fibroblasts,Parasite,inhibit,HEp2,3 LL,malaria,HSV,Inhibitor,SAH,HSV-1,Herpes simplex virus,cancer,RMS-J1,SIBA,Nucleoside Antimetabolite/Analog

(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((isobutylthio)methyl)tetrahydrofuran-3,4-diol

5'-Isobutylthio-5'-deoxyadenosine

SIBA, 10 mM in DMSO

5'-Isobutylthio-5'-deoxyadenosine

35899-54-8