ChemicalBook > CAS DataBase List > NU7026

NU7026

Product Name
NU7026
CAS No.
154447-35-5
Chemical Name
NU7026
Synonyms
CS-595;LY 293646;NU7026, >=98%;NU 7026; NU-7026;NU7026 USP/EP/BP;NU7026;LY293646; NU-7026;DNA-PK Inhibitor II NU7026 NU-7026;2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE;2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one;2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
CBNumber
CB8503981
Molecular Formula
C17H15NO3
Formula Weight
281.31
MOL File
154447-35-5.mol
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NU7026 Property

Melting point:
267-269 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point:
459.9±45.0 °C(Predicted)
Density 
1.330
storage temp. 
2-8°C
solubility 
DMSO: 3 mg/mL at 60 °C, soluble
form 
solid
pka
0.49±0.20(Predicted)
color 
tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1537
Product name
NU7026
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$279
Updated
2024/03/01
Sigma-Aldrich
Product number
260961
Product name
DNA-PK Inhibitor II
Packaging
5mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
13308
Product name
NU 7026
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
13308
Product name
NU 7026
Purity
≥95%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
13308
Product name
NU 7026
Purity
≥95%
Packaging
25mg
Price
$356
Updated
2024/03/01
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NU7026 Chemical Properties,Usage,Production

Uses

DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK.

Uses

NU7026 has been used:

  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Definition

ChEBI: 2-(4-morpholinyl)-4-benzo[h][1]benzopyranone is an organooxygen compound and an organic heterotricyclic compound.

Biological Activity

ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

storage

Store at +4°C

NU7026 Preparation Products And Raw materials

Raw materials

Preparation Products

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NU7026 Suppliers

China 88 India 1 Switzerland 1 United Kingdom 2 United States 14 Global 106
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from NU7026 manufacturers

Career Henan Chemical Co
Product
NU7026 154447-35-5
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-24

154447-35-5, NU7026Related Search:

Imidazolidinyl urea NU7441 (KU-57788) KU-55933 (ATM Kinase Inhibitor) VE-821 KU-60019 ABT 737 Olaparib NU7026 4H-1-Benzopyran-4-one, 2-(diethylamino)-

  • DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem
  • NU 7026; NU-7026
  • CS-595
  • 2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE
  • NU7026, >=98%
  • 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
  • NU7026;LY293646; NU-7026
  • LY 293646
  • 2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
  • 4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-
  • 2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one NU7026
  • NU7026 USP/EP/BP
  • DNA-PK Inhibitor II NU7026 NU-7026
  • DNA-dependent protein kinase,inhibit,NU-7026,Apoptosis,DNA-PK,LY-293646,Inhibitor,LY 293646,NU 7026
  • 154447-35-5
  • Inhibitors