ChemicalBook > CAS DataBase List > 6-Methyl-2-(methylthio)pyrimidin-4-ol

6-Methyl-2-(methylthio)pyrimidin-4-ol

Product Name: 6-Methyl-2-(methylthio)pyrimidin-4-ol
CAS No.: 6328-58-1
Chemical Name: 6-Methyl-2-(methylthio)pyrimidin-4-ol
Synonyms: NSC37678;NSC43815;ST074533;NSC193525;ST5114026;ZINC05182359;ZINC00039515;ZINC03864720;Enamine_001117;6-Methyl-2-(methylthio)
CBNumber: CB8663120
Molecular Formula: C6H8N2OS
Formula Weight: 156.21
MOL File: 6328-58-1.mol

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6-Methyl-2-(methylthio)pyrimidin-4-ol Property

Melting point:: 224-226°C
Boiling point:: 259.2±23.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 8.24±0.50(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39-24/25
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R683868
Product name: 6-METHYL-2-(METHYLTHIO)-4(3H)-PYRIMIDINONE
Purity: AldrichCPR
Packaging: 10MG
Price: $148
Updated: 2025/07/31

Sigma-Aldrich

Product number: 775754
Product name: 4-Hydroxy-6-methyl-2-methylthiopyrimidine
Purity: 97%
Packaging: 5g
Price: $268
Updated: 2023/06/20

TRC

Product number: M338678
Product name: 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR939412
Product name: 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one
Purity: 95%
Packaging: 10g
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: Z2590
Product name: 2-Methylmercapto-4-hydroxy-6-methylpyrimidine
Packaging: 10g
Price: $141
Updated: 2021/12/16

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6-Methyl-2-(methylthio)pyrimidin-4-ol Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

56-04-2

74-88-4

6328-58-1

Sodium hydroxide (97%, 15.7 g, 381 mmol) was added to 500 mL of water and the suspension was stirred for 10 min at room temperature. 6-Methyl-2-thioxasulfinyl-1,2,3,4-tetrahydropyrimidin-4-one (98%, 53.5 g, 369 mmol) was added and the mixture was stirred until completely dissolved for 10 minutes. Iodomethane (28.99 mL, 461 mmol) was slowly added dropwise and the reaction mixture continued to be stirred for 4 hours at room temperature. After completion of the reaction, a colorless solid was obtained by filtration, washed with ice-cold water (2 x 100 mL) and dried under vacuum at 60 °C to give 6-methyl-4-hydroxy-2-methylthiopyrimidine (57 g, 98% yield) as a colorless solid. The product was analyzed by LC-MS: m/z = 156.9 [M + H]+; retention time (RT) = 0.61 min.

References

[1] Patent: WO2017/59191, 2017, A1. Location in patent: Paragraph 00126-00129
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 18, p. 3025 - 3030
[3] Archiv der Pharmazie, 1984, vol. 317, # 5, p. 425 - 430

6-Methyl-2-(methylthio)pyrimidin-4-ol Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate 2-Methyl-2-thiopseudourea sulfate Sodium carbonate

Preparation Products

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6-Methyl-2-(methylthio)pyrimidin-4-ol Suppliers

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View Lastest Price from 6-Methyl-2-(methylthio)pyrimidin-4-ol manufacturers

Dideu Industries Group Limited

Product: 6-METHYL-2-(METHYLTHIO)PYRIMIDIN-4-OL
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-08

6328-58-1, 6-Methyl-2-(methylthio)pyrimidin-4-olRelated Search:

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NSC43815

ST074533

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6-Methyl-2-(methylthio)pyrimidin-4-ol ISO 9001：2015 REACH

4-methyl-2-methylsulfanyl-1H-pyrimidin-6-one

6-METHYL-2-(METHYLTHIO)-4(3H)-PYRIMIDINONE

6328-58-1