Polymyxin B sulfate

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Polymyxin B sulfate

Indications Dosage Drug Interactions Injection polymyxin B sulfate manufacturer Precautions Uses

Product Name: Polymyxin B sulfate
CAS No.: 1405-20-5
Chemical Name: Polymyxin B sulfate
Synonyms: POLYMYXIN B;POLYMYXIN B SULPHATE;POLYMIXIN B SULFATE;AEROSPORIN;POLYMIXIN B SULPHATE;polymyxin B sulfate usp;Polymyxin B sulfate for microbiological assay;N-[3-AMino-1-[[1-[[3-aMino-1-[[6,9,18-tris(2-aMinoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-Methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbaMoyl]propyl]carbaMoyl]-2-hydroxy-propyl]carbaMoyl]pro;Poly-RX;APPLISORB
CBNumber: CB8666707
Molecular Formula: C56H100N16O17S
Formula Weight: 1301.56
MOL File: 1405-20-5.mol

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Polymyxin B sulfate Property

Melting point:: 217-220°C (dec.)
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL
form: powder
pka: pKa 8.9 (Uncertain)
color: colorless or slightly yellow
PH: pH (10g/L, 25℃) : 4.5～7.0
optical activity: [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
Water Solubility: Soluble in water at 50mg/ml/n
Merck: 14,7573
Stability:: Hygroscopic
InChIKey: HFMDLUQUEXNBOP-UHFFFAOYSA-N
LogP: -6.361 (est)
CAS DataBase Reference: 1405-20-5(CAS DataBase Reference)
EPA Substance Registry System: Polymixin B sulfate (1405-20-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-24/25
RIDADR: 3249
WGK Germany: 3
RTECS: TR1150000
F: 3-8-10
HS Code: 2941 90 00
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: dog,LDLo,intracrebral,320ug/kg (0.32mg/kg),BEHAVIORAL: COMA,British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P4932
Product name: Polymyxin B sulfate salt
Purity: powder, BioReagent, suitable for cell culture
Packaging: 1000000units
Price: $51.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1004
Product name: Polymyxin B sulfate salt
Packaging: 1000000units
Price: $55.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1004
Product name: Polymyxin B sulfate salt
Packaging: 5000000units
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: P4932
Product name: Polymyxin B sulfate salt
Purity: powder, BioReagent, suitable for cell culture
Packaging: 5000000units
Price: $177
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1004
Product name: Polymyxin B sulfate salt
Packaging: 10000000units
Price: $237
Updated: 2024/03/01

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Polymyxin B sulfate Chemical Properties,Usage,Production

Indications

Polymyxin B sulfate is similar with polymyxin E, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Escherichia coli deputy, Klebsiella pneumoniae, acidophilus, Bordetella pertussis and Shigella dysentery. It is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by Pseudomonas aeruginosa and other kinds of pseudomonas. It can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and Pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.

Dosage

1. Intravenous injection: Adults and children with normal renal function: 1.5 to 2.5 mg per kilogram of body weight per day (for per kg body weight, generally apply not more than 2.5 mg), divide into 2 times with 1 time every 12 hours of infusion. Dilute every 50mg of the product with 500 mL of 5% glucose solution and further add drop wise. Babies with normal renal function can tolerate a amount of 4 mg/day per kilogram of body weight.
2. Intramuscular injection: Adults and children: apply 2.5 to 3 mg per kilogram of body weight; apply in divided doses with applying 1 time every 4 to 6 hours. For baby, the dosage can be 4 mg per day per kilogram of body weight. For new born children, we can apply to 4.5 mg per time per kilogram of body weight.
3. intrathecal injection (for Pseudomonas aeruginosa meningitis): Each mL of drug solution prepared by the sodium chloride injection contains 5mg. Adults and children with over 2 years of age, apply 5 mg daily; after application of 3 to 4 days, change one time every other day, and continue for at least 2 weeks until the result of cerebrospinal fluid culture becomes negative and the sugar inspection becomes normal. For children less than 2 years of age, apply 2mg 1 time per day for continuous 3 to 4 days (or 2.5mg per every other day); after that, apply 2.5mg every other day, until the test becomes normal.
4. The ophthalmic solution concentration: 1~2.5mg per milliliter.

Drug Interactions

We should avoid apply it in combination with drugs causing significant damage to the kidneys, skeletal muscle relaxants, aminoglycoside antibiotics, and anesthetic drugs with significant effect of muscle relaxation (such as enflurane). Also we should avoid simultaneous intravenous administration of quinine, and magnesium. Combining polymyxin B sulfate with sulfa drugs, rifampicin, and semi-synthetic penicillin has a better efficacy than single application in treating severe infections resistant Gram-negative bacteria.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Injection polymyxin B sulfate manufacturer

Shanghai “Xin Xianfeng” Pharmaceutical Co., Ltd. Zhunzi H31022973
Shanghai No. 1 Biochemical Pharmaceutical Co., Ltd. Zhunzi H31022631

Precautions

1. Pregnant and lactating women, children, patients with severe kidneys damage and severe kidney dysfunction should either take with caution or reduce the administrated amount.
2. this product has relative large toxicity and a poor efficacy in treating deep tissue infection. It is also not the primary choice of drug for treating any kinds of infection.
3. intravenous injection may lead to respiratory depression and thus should generally not used. Half of the amount in daily dose should subject to intravenous drip, and can’t subject to disposable rapid bolus avoid extensive neuromuscular blockade.
4. it shouldn’t be used in combination with drugs with other renal toxicity or neuromuscular blocking effects to avoid accidents.

Uses

Biochemical studies.
Polymyxin B is a kind of anti-Gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of Gram-negative bacteria. It has bactericidal effect on Escherichia coli through binding to the lipid A portion of bacterial lipopolysaccharide. Mechanism of action: bind and interfere with the permeability o the cellular membrane. Anti-bacteria spectrum: gram negative bacteria.

Description

The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B₁ to B₄, with polymyxin B₁ and B₂ being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.

Chemical Properties

White Solid

Uses

antibacterial

Uses

Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.

Uses

Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixtu re of Polymyxin B1 and B2 sulfate. Biological potency (dry basis): >6000U/mg.

Indications

Polymyxin B is one of a group of cyclic polypeptides elaborated by Bacillus polymyxa. The drug is a surface-active agent. It is thought to alter the lipoprotein membrane of bacteria so that it no longer functions as an effective barrier, thereby allowing the cell contents to escape. Polymyxin B is effective against Pseudomonas, E. coli, and other gram-negative bacteria except the Proteus and Serratia species. It has little effect on gram-positive organisms.

brand name

(GlaxoSmithKline); Poly-Rx (X Gen).

General Description

Polymyxin (Aerosporin) was discovered in 1947 almost simultaneouslyin three separate laboratories in the UnitedStates and Great Britain. As often happens whensimilar discoveries are made in widely separated laboratories,differences in nomenclature, referring to both theantibiotic-producing organism and the antibiotic itself, appearedin references to the polymyxins. Because the organismsfirst designated as Bacillus polymyxa and B.aerosporus Greer were found to be identical species, thename B. polymyxa is used to refer to all of the strains thatproduce the closely related polypeptides called polymyxins.Other organisms (e.g., see “Colistin” later) also producepolymyxins. Identified so far are polymyxins A, B1,B2, C, D1, D2, M, colistin A (polymyxin E1), colistin B(polymyxin E2), circulins A and B, and polypeptin. Theknown structures of this group and their properties havebeen reviewed by Vogler and Studer. Of these,polymyxin B as the sulfate usually is used in medicine because,when used systemically, it causes less kidney damagethan the others. Polymyxin B sulfate is a nearly odorless, white to buff powder. It is freely soluble in water and slightly soluble in alcohol.

Biochem/physiol Actions

Polymyxin B?is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant?Enterobacteriaceae.

Clinical Use

Polymyxin B is produced by fermentation of Bacillus polymyxa. It is separated from a mixture of related cyclic peptides and is primarily active against Gram-negative microorganisms. It apparently binds to phosphate groups in bacterial cytoplasmic membranes and disrupts their integrity. It is used IM or IV as a sulfate salt to treat serious urinary tract infections, meningitis, and septicemia, primarily caused by Pseudomonas aeruginosa, but some other Gram-negative bacteria also will respond. Irrigation of the urinary bladder with solutions of polymyxin B sulfate is employed as well by some to reduce the incidence of infections subsequent to installation of indwelling catheters. Additionally, it is used ophthalmically to treat infections by P. aeruginosa. When given parenterally, the drug is neuro- and nephrotoxic and, therefore, is employed only after other drugs have failed.

in vitro

polymyxin b elicited up-regulation of dendritic cells (dcs) maturation markers, including the increase in the in the expression of co-stimulatory molecule cd86 and hla-class i and ii molecules. polymyxin b induced a progressive increase in the adhesion property of human dcs. in addition, polymyxin b triggered the activation of the erk1/2 pathway and iκb-α/nf-κb pathways [1].

in vivo

male bacteraemia ddy mice were subcutaneously treated with polymyxin b at a dose of 5, 10, 15 or 20 mg/kg for 7 days. polymyxin b, in a dose-dependent fashion, improved the survival both of ou-01062- and ou-98039-infected mice. in polymyxin b-treated mice, except for 5 mg/kg polymyxin b, the viable cell counts had a tendency to reduce steadily in each concentration group. it was showed a rapid and marked decline of bacterial cell count between 3 to 6 h after infection [2].

storage

Room temperature

References

[1]. valentinis, b., bianchi, a., zhou, d., cipponi, a., catalanotti, f., russo, v., & traversari, c. direct effects of polymyxin b on human dendritic cells maturation: the role of i b- /nf- b and erk1/2 pathways and adhesion. journal of biological chemistry. 2005; 280(14): 14264-14271.
[2]. miyajima, y., hiramatsu, k., mizukami, e., morinaga, r., ishii, h., & shirai, r. et al. in vitro and in vivo potency of polymyxin b against imp-type metallo-β-lactamase-producing pseudomonas aeruginosa. international journal of antimicrobial agents. 2008; 32(5): 437-440.

Polymyxin B sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Polymyxin B sulfate manufacturers

Anhui Yiao New Material Technology Co., Ltd

Product: polymyxin B standard solution 1405-20-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 tons
Release date: 2023-08-09

Anhui Yiao New Material Technology Co., Ltd

Product: polymyxin B standard solution 1405-20-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 tons
Release date: 2023-08-09

Anhui Yiao New Material Technology Co., Ltd

Product: polymyxin B standard solution 1405-20-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 tons
Release date: 2023-08-09

1405-20-5, Polymyxin B sulfateRelated Search:

POLYMYXIN E SULFATE COLISTIN Benzyl nicotinate Copper(II) sulfate Benzyl alcohol Barium sulfate Ammonium sulfate Aluminum sulfate CHONDROITIN SULFATE B SODIUM SALT Magnesium sulfate Dimethyl sulfate Ferrous sulfate heptahydrate polymyxin B 2.5sulfate entahydrate,Polymyxin B (base and/or unspecified salts) Benzyl isocyanate Benzyl chloride Tricine Tris(hydroxymethyl)aminomethane Sodium sulfate Polymyxin B Sulfate Salt

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AEROSPORIN

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APPLISORB

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m-CP-Selektiv-Supplement I

POLYMYXIN B SULFATE CELL CULTURE REAGENT

N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide sulfuric acid

PolyoxyalkyleneGlycol

PolymyxineBsulfate

Polymixin B-Sulfate USP

POLYMYXINBSULFATE,MICRONIZED,USP

POLYGONUNCUSPIDATUMP.E

Polymyxin B Sulfate (Aerosporin)

Polymyxin B sulfate, >6500 IU/mg, suitable for cell culture

PolyMyxin B sulphate (USP35,EP7.0)

PolyMyxin-B-sulfate research grade

Polymyxin B sulfate N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbam

Polymyxin B sulfate for microbiological assay

Aerosporin PolyMyxin B Sulfate

Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested

Polymyxin B sulfate for microbiological assay CRS

Polymyxin B sulfate CRS

Poly-RX

Polymyxin B sulfate USP/EP/BP

Polymyxin B sulfate (P2400000)

Polymyxin B Sulphate [Mixture of Isomres]Q: What is Polymyxin B Sulphate [Mixture of Isomres] Q: What is the CAS Number of Polymyxin B Sulphate [Mixture of Isomres] Q: What is the storage condition of Polymyxin B Sulphate [Mixture of Isomres]

Polymyxin B Sulphate (Aerosporin, PXNS), 6000U/mg

Polymyxin B Sulphate (Aerosporin, PXNS), 6000U/mg for cell culture

Polymyxin B Sulfate (COLD SHIPMENT REQUIRED) (1547007)

POLYMYXIN B SULPHATE Extra Pure

Polymyxin B sulfate (1404-26-8 free base)