4-Chloro-2,3-dimethylpyridine 1-oxide
- Product Name
- 4-Chloro-2,3-dimethylpyridine 1-oxide
- CAS No.
- 59886-90-7
- Chemical Name
- 4-Chloro-2,3-dimethylpyridine 1-oxide
- Synonyms
- NSC 27526;nsc 275262;Lansoprazole-15;4-Chloro-2,3-dimethy;Rabeprazole Impurity 40;Lansoprazole Impurity 57;Lansoprazole Impurity B-9;Lansoprazole EP Impurity 16;3-DiMethyl-4-chloropyridine N-oxide;2,3-DiMethyl-4-chloropyridne-n-oxide
- CBNumber
- CB8670430
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 59886-90-7.mol
4-Chloro-2,3-dimethylpyridine 1-oxide Property
- Melting point:
- 103-105°C
- Boiling point:
- 338.5°C
- Density
- 1.19
- vapor pressure
- 0.346Pa at 25℃
- Flash point:
- 158.5°C
- storage temp.
- Room temperature.
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.28±0.10(Predicted)
- color
- Pale Yellow to Light Beige
- LogP
- 0.4 at 25℃
- CAS DataBase Reference
- 59886-90-7(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T138479
- Product name
- 4-CHLORO-2,3-DIMETHYLPYRIDINE 1-OXIDE
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- C2820
- Product name
- 4-Chloro-2,3-dimethylpyridine N-Oxide
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2024/03/01
- Product number
- C2820
- Product name
- 4-Chloro-2,3-dimethylpyridine N-Oxide
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 268163
- Product name
- 4-Chloro-2,3-dimethylpyridine N-oxide
- Packaging
- 5g
- Price
- $326
- Updated
- 2021/12/16
- Product number
- C365450
- Product name
- 4-Chloro-2,3-dimethylpyridine N-Oxide
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
4-Chloro-2,3-dimethylpyridine 1-oxide Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
An intermediate in the synthesis of rabeprazole (R070500).
Synthesis
83.0 g (0.49 mol) of 4-nitro-2,3-dimethylpyridine N-oxide and 90 g (1.54 mol) of NaCl were admixed with 1350 ml of CH3CN, 180 ml of aq. HCl (36%) and 16.6 g of benzyltributylammonium chloride, and the resulting suspension was boiled under reflux with stirring for 12 h. The resulting reaction mixture was adjusted to PH=9 using 350 ml of 20% NaOH, wherefor the existing precipitate largely dissolved. The organic phase was separated off, water was added to the aqueous phase until the precipitate had completely dissolved, and it was subsequently extracted using dichloromethane. The organic phases were combined and the solvent was removed under reduced pressure. 76.6 g (98.5%) of 4-Chloro-2,3-dimethylpyridine 1-oxide were obtained.
4-Chloro-2,3-dimethylpyridine 1-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-2,3-dimethylpyridine 1-oxide manufacturers
- Product
- 4-Chloro-2,3-dimethylpyridine-N-oxide 59886-90-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2019-12-27
- Product
- 4-Chloro-2,3-dimethylpyridine 1-oxide 59886-90-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- 4-Chloro-2,3-dimethylpyridine1-oxide 59886-90-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-17