MK-886

Product Name: MK-886
CAS No.: 118414-82-7
Chemical Name: MK-886
Synonyms: MK866;MK-886;CS-1988;L-663,536;CGS-81585;MK-886 (Base);MK-886 (L-663,536);MK-886 (Free Base);MK886, Lipoxygenase inhibitor;3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
CBNumber: CB8671381
Molecular Formula: C27H34ClNO2S
Formula Weight: 472.08
MOL File: 118414-82-7.mol

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MK-886 Property

Melting point:: 295-297°C
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 32 mg/mL
form: White solid.
color: white
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 475889
Product name: MK-886 - CAS 118414-82-7 - Calbiochem
Packaging: 5MG
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 21753
Product name: MK-886
Purity: ≥98%
Packaging: 25mg
Price: $330
Updated: 2024/03/01

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MK-886 Chemical Properties,Usage,Production

Description

MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10 μM).3

Chemical Properties

White Solid

Uses

Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes.

Uses

MK-886 is a potent and selective inhibitor of FLAP and Cox-1.

Definition

ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.

Biological Activity

An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .

storage

Store at RT

References

References/Citations 1) Gillard et al (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor; Can. .J. Physiol .Pharmacol. 67 456 2) Evans et al (1991) 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors; Mol. Pharmacol. 40 22 3) Kehrer et al (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886; Biochem. J. 356 899

MK-886 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-886 Suppliers

Canada 1 China 109 Europe 1 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 2 United States 19 Global 139

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View Lastest Price from MK-886 manufacturers

Career Henan Chemical Co

Product: MK-886 118414-82-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

118414-82-7, MK-886Related Search:

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Fatostatin A JNJ 1661010 NAGLY MK-886,MK 886 SODIUM SALT,mk-886 sodium hydrate,MK-886 hydrate sodium salt MK-886

L-663,536

CS-1988

1-[(4-CHLOROPHENYL)METHYL]-3-[(1,1-DIMETHYLETHYL)THIO]-ALPHA,ALPHA-DIMETHYL-5-(1-METHYLETHYL)-1H-INDOLE-2-PROPANOIC ACID

MK-886

3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt

3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid

3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid

3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid

CGS-81585

3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid

1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-

1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid

3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid

MK-886 (Free Base)

MK-886 (L-663,536)

3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid

MK866

1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-

leukotriene,FLAP,5-LOX,5-LO activating protein,non-competitive,L-663536,L663536,keratin-1,Leukotriene Receptor,Inhibitor,biosynthesis,Peroxisome proliferator-activated receptors,PPAR,PPARα,Apoptosis,MK 886,MK-886,inhibit

MK-886 (Base)

MK886, Lipoxygenase inhibitor

118414-82-7

C27H34ClNO2S

All Inhibitors

Inhibitors

Prostanoid receptor and related