ChemicalBook > CAS DataBase List > 4-Acetoxy-2-azetidinone

4-Acetoxy-2-azetidinone

Product Name
4-Acetoxy-2-azetidinone
CAS No.
28562-53-0
Chemical Name
4-Acetoxy-2-azetidinone
Synonyms
4-Oxo-2-azetidinyl acetate;4-ACETOXY-2-AZETIDINONE;3-Acetoxy-3-propanelactam;4-Acetyloxyazetidin-2-one;4-OXOAZETIDIN-2-YLACETATE;2-oxoazetidinium 4-acetate;4-ACETOXY-2-AZETIDINONE(4-AA);2-Azetidinone, 4-(acetyloxy)-;Acetic acid 4-oxo-2-azetidinyl ester;Acetic acid 2-oxoazetidin-4-yl ester
CBNumber
CB8672313
Molecular Formula
C5H7NO3
Formula Weight
129.11
MOL File
28562-53-0.mol
More
Less

4-Acetoxy-2-azetidinone Property

Melting point:
38-40 °C (lit.)
Boiling point:
239.15°C (rough estimate)
Density 
1.3816 (rough estimate)
refractive index 
1.4220 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
formic acid: soluble50mg/mL, clear, yellow-orange
pka
13.41±0.40(Predicted)
BRN 
1524738
CAS DataBase Reference
28562-53-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Acetoxy-2-azetidinone(28562-53-0)
More
Less

Safety

Hazard Codes 
C
Risk Statements 
34-43
Safety Statements 
26-36/37/39-45
RIDADR 
UN 1759 8/PG 2
WGK Germany 
3
HazardClass 
8
PackingGroup 
III
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
272159
Product name
4-Acetoxy-2-azetidinone
Purity
98%
Packaging
1g
Price
$125
Updated
2023/01/07
Sigma-Aldrich
Product number
272159
Product name
4-Acetoxy-2-azetidinone
Purity
98%
Packaging
5g
Price
$300
Updated
2023/01/07
TRC
Product number
A187958
Product name
4-Acetoxy-2-azetidinone
Packaging
100mg
Price
$75
Updated
2021/12/16
Synthonix
Product number
A15221
Product name
4-Acetoxy-2-azetidinone
Purity
95+%
Packaging
1g
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30790
Product name
4-Acetoxy-2-azetidinone
Packaging
1g
Price
$80
Updated
2021/12/16
More
Less

4-Acetoxy-2-azetidinone Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

4-Acetoxy-2-azetidinone was used in the synthesis of derivatized cyclopentenes in high regio- and diastereoselectivity. It was also used as a heterocyclic synthon for antibiotic and anti-inflammatory agents.

Synthesis Reference(s)

Journal of the American Chemical Society, 112, p. 7820, 1990 DOI: 10.1021/ja00177a067
Tetrahedron Letters, 29, p. 1409, 1988 DOI: 10.1016/S0040-4039(00)80310-X

Purification Methods

Dissolve it in CHCl3, dry (MgSO4) concentrate at 40o/70mm, or better at room temperature to avoid decomposition. Wash and stir the residual oil with hexane by decantation and discard the wash. Dry the oil at high vacuum when it should solidify, m 34o. It can be distilled at high vacuum, 80-82o/10-3mm, but this results in extensive losses. The purity can be checked by TLC using Merck Silica Gel F254 and eluting with EtOAc. The azetidinone has RF 0.38 (typical impurities have RF 0.67). The spots can be detected by the TDM spray. This is prepared from (A) 2.5g 4,4'-tetramethyldiaminodiphenylmethane (TDM) in 10mL AcOH and diluted with 50mL of H2O, (B) 5g KI in 100mL of H2O and (C) 0.3g ninhydrin in 10mL of AcOH and 90mL of H2O. The spray is prepared by mixing (A) and (B) with 1.5mL of (C) and stored in a brown bottle. [Clau et al. Justus Liebigs Ann Chem 539 1974, Michel et al. Org Synth 65 135 1987, Beilstein 21/12 V 4.]

4-Acetoxy-2-azetidinone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Acetoxy-2-azetidinone Suppliers

Canada 1 China 117 Europe 2 Germany 3 India 4 Switzerland 1 United Kingdom 11 United States 23 Global 162
Shanghai Xinhua Chemical Technology Co., Ltd
Tel
086-18817515273 18817515273
Email
hm-huangmiao@163.com
Country
China
ProdList
383
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9895
Advantage
55
Nanjing Credit Trading Co.,Ltd
Tel
025-52164950
Fax
025-86800069
Email
Googlexu_0114@sina.com
Country
China
ProdList
644
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10021
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Xishi Chemical (Shanghai) Co., Ltd.
Tel
021-60499358 13661956116
Fax
+86 (21) 5106-9359
Email
info@cs-pharm.com
Country
China
ProdList
199
Advantage
58
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
021-54581719 13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1722
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7980
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3331
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Suzhou JingTong Pharmaceutical Co., Ltd.
Tel
13675155016
Fax
18912765016
Email
tongtf110@sina.com
Country
China
ProdList
963
Advantage
55
WG reagent
Tel
13391486464
Fax
QQ:14748090
Email
samwjf@163.com
Country
China
ProdList
3086
Advantage
55
Suzhou Future Chemical Technology Co., Ltd.
Tel
13921981169
Fax
-
Email
ftchem2016@163.com
Country
China
ProdList
464
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4014
Advantage
58
Shanghai Bank Pharma Limited
Tel
021-2221346380 021-54220652 17701603001
Fax
QQ:2221346380
Email
bankpharma@163.com
Country
China
ProdList
438
Advantage
58
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9186
Advantage
65
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28809
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15494
Advantage
58
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
13913522962
Email
180642609@qq.com
Country
China
ProdList
4967
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24969
Advantage
58
Nanjing SynTitan Pharmaceutical Co., Ltd.
Tel
25-57027686 17372956142
Fax
025-57027686
Email
li_lan@syntitan.com
Country
China
ProdList
10000
Advantage
58
Shanghai Tube Pharmaceutical Co., Ltd.
Tel
021-54338626 18017892860
Fax
021-54338626
Email
sales@tubepharm.com
Country
China
ProdList
2416
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Pinghu city zhengyuan medical technology co. LTD
Tel
18367600069
Fax
QQ3388371646
Email
pinghushizy@163.com
Country
China
ProdList
7803
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9639
Advantage
58
More
Less

View Lastest Price from 4-Acetoxy-2-azetidinone manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-Acetoxy-2-azetidinone 28562-53-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-14
Career Henan Chemical Co
Product
4-Acetoxy-2-azetidinone 28562-53-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 794
Release date
2019-09-02

28562-53-0, 4-Acetoxy-2-azetidinoneRelated Search:

2-Azetidinone (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Acetoxyacetyl chloride Sodium triacetoxyborohydride SILICON TETRAACETATE Acetoxyacetic acid 4-BROMOMETHYLBIPHENYL 4-Aminopyrimidine 4-BroMo-3-Methyl-7-azaindole 4-Bromoindole (3R,4R)-4-ACETOXY-3-[(3R)-1-(BUTYLDIMETHYL-SILYOXY)-ETHYL]-2-AZETIDIONE Cyclobutanone 4-BENZOYLOXY-2-AZETIDINONE Acetoxy 4-Acetoxy-2-azetidinone

  • 2-Azetidinone, 4-(acetyloxy)-
  • 4-Oxo-2-azetidinyl acetate
  • 4-ACETOXY-2-AZETIDINONE
  • 3-Acetoxy-3-propanelactam
  • 2-oxoazetidinium 4-acetate
  • 4-OXOAZETIDIN-2-YLACETATE
  • 4-ACETOXY-2-AZETIDINONE(4-AA)
  • 4-Acetyloxyazetidin-2-one
  • Acetic acid 2-oxoazetidin-4-yl ester
  • Acetic acid 4-oxo-2-azetidinyl ester
  • acetic acid (2-oxo-1-azetidinyl) ester
  • 28562-53-0
  • C5H7NO312911
  • Lactams
  • Organic Building Blocks
  • Building Blocks
  • Carbonyl Compounds
  • Carbonyl Compounds
  • Lactams
  • Organic Building Blocks
  • Ring Systems