4-Acetoxy-2-azetidinone
- Product Name
- 4-Acetoxy-2-azetidinone
- CAS No.
- 28562-53-0
- Chemical Name
- 4-Acetoxy-2-azetidinone
- Synonyms
- 4-Oxo-2-azetidinyl acetate;4-ACETOXY-2-AZETIDINONE;3-Acetoxy-3-propanelactam;4-Acetyloxyazetidin-2-one;4-OXOAZETIDIN-2-YLACETATE;2-oxoazetidinium 4-acetate;4-ACETOXY-2-AZETIDINONE(4-AA);2-Azetidinone, 4-(acetyloxy)-;Acetic acid 4-oxo-2-azetidinyl ester;Acetic acid 2-oxoazetidin-4-yl ester
- CBNumber
- CB8672313
- Molecular Formula
- C5H7NO3
- Formula Weight
- 129.11
- MOL File
- 28562-53-0.mol
4-Acetoxy-2-azetidinone Property
- Melting point:
- 38-40 °C (lit.)
- Boiling point:
- 239.15°C (rough estimate)
- Density
- 1.3816 (rough estimate)
- refractive index
- 1.4220 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- formic acid: soluble50mg/mL, clear, yellow-orange
- pka
- 13.41±0.40(Predicted)
- BRN
- 1524738
- CAS DataBase Reference
- 28562-53-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Acetoxy-2-azetidinone(28562-53-0)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-43
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 1759 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 272159
- Product name
- 4-Acetoxy-2-azetidinone
- Purity
- 98%
- Packaging
- 1g
- Price
- $125
- Updated
- 2023/01/07
- Product number
- 272159
- Product name
- 4-Acetoxy-2-azetidinone
- Purity
- 98%
- Packaging
- 5g
- Price
- $300
- Updated
- 2023/01/07
- Product number
- A187958
- Product name
- 4-Acetoxy-2-azetidinone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FA30790
- Product name
- 4-Acetoxy-2-azetidinone
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- APN0000239
- Product name
- 4-ACETOXY AZETIDIN-2-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $155.4
- Updated
- 2021/12/16
4-Acetoxy-2-azetidinone Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
4-Acetoxy-2-azetidinone was used in the synthesis of derivatized cyclopentenes in high regio- and diastereoselectivity. It was also used as a heterocyclic synthon for antibiotic and anti-inflammatory agents.
Synthesis Reference(s)
Journal of the American Chemical Society, 112, p. 7820, 1990 DOI: 10.1021/ja00177a067
Tetrahedron Letters, 29, p. 1409, 1988 DOI: 10.1016/S0040-4039(00)80310-X
Purification Methods
Dissolve it in CHCl3, dry (MgSO4) concentrate at 40o/70mm, or better at room temperature to avoid decomposition. Wash and stir the residual oil with hexane by decantation and discard the wash. Dry the oil at high vacuum when it should solidify, m 34o. It can be distilled at high vacuum, 80-82o/10-3mm, but this results in extensive losses. The purity can be checked by TLC using Merck Silica Gel F254 and eluting with EtOAc. The azetidinone has RF 0.38 (typical impurities have RF 0.67). The spots can be detected by the TDM spray. This is prepared from (A) 2.5g 4,4'-tetramethyldiaminodiphenylmethane (TDM) in 10mL AcOH and diluted with 50mL of H2O, (B) 5g KI in 100mL of H2O and (C) 0.3g ninhydrin in 10mL of AcOH and 90mL of H2O. The spray is prepared by mixing (A) and (B) with 1.5mL of (C) and stored in a brown bottle. [Clau et al. Justus Liebigs Ann Chem 539 1974, Michel et al. Org Synth 65 135 1987, Beilstein 21/12 V 4.]
4-Acetoxy-2-azetidinone Preparation Products And Raw materials
Raw materials
Preparation Products
4-Acetoxy-2-azetidinone Suppliers
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- Country
- Switzerland
- ProdList
- 6896
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View Lastest Price from 4-Acetoxy-2-azetidinone manufacturers
- Product
- 4-Acetoxy-2-azetidinone 28562-53-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-14
- Product
- 4-Acetoxy-2-azetidinone 28562-53-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 794
- Release date
- 2019-09-02