3,4-DIHYDROISOQUINOLINE Property

Melting point:

251-254℃

Boiling point:

241.8±20.0℃ (760 Torr)

Density 

1.05±0.1 g/cm3 (20 ºC 760 Torr)

refractive index 

1.6041 (589.3 nm 30℃)

Flash point:

91.6±22.6℃

storage temp. 

2-8°C

pka

5.80±0.20(Predicted)

Safety

Hazard Codes 

T

Risk Statements 

22-24-36/38

Safety Statements 

26-36/37-45

RIDADR 

UN 2811 6.1 / PGII

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H310Fatal in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3,4-DIHYDROISOQUINOLINE Chemical Properties,Usage,Production

Uses

3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors.

Uses

3,4-Dihydroisoquinoline can be used as a reactant to synthesize:

• 5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI).
• 1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols.
• 3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6567, 1994 DOI: 10.1016/S0040-4039(00)78274-8