6-Chlorooxindole

Preparation

Product Name: 6-Chlorooxindole
CAS No.: 56341-37-8
Chemical Name: 6-Chlorooxindole
Synonyms: 6-chloroindolin-2-one;6-CHLORO-2-OXINDOLE;6-Chloro-2-oxoindole;AKOS 207-09;6-CHLOROOXINDOLE;6-CHLORO0XINDOLE;Isatin Impurity 18;6-Chlorooxindole 98%;6-Chlorooxindole,98%;6-Chlorooxindole >
CBNumber: CB8681061
Molecular Formula: C8H6ClNO
Formula Weight: 167.59
MOL File: 56341-37-8.mol

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6-Chlorooxindole Property

Melting point:: 195-199 °C (lit.)
Boiling point:: 329.0±42.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Dimethylformamide
form: powder to crystal
pka: 13.39±0.20(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C8H6ClNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11)
InChIKey: CENVPIZOTHULGJ-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(Cl)=C2)CC1=O
CAS DataBase Reference: 56341-37-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-43-36/37/38
Safety Statements: 37/39-36-26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 636215
Product name: 6-Chloro-2-oxindole
Purity: 97%
Packaging: 5g
Price: $23.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 636215
Product name: 6-Chloro-2-oxindole
Purity: 97%
Packaging: 25g
Price: $42.7
Updated: 2024/03/01

TCI Chemical

Product number: C2024
Product name: 6-Chlorooxindole
Purity: >98.0%(GC)
Packaging: 5g
Price: $32
Updated: 2024/03/01

TCI Chemical

Product number: C2024
Product name: 6-Chlorooxindole
Purity: >98.0%(GC)
Packaging: 25g
Price: $95
Updated: 2024/03/01

Alfa Aesar

Product number: A19674
Product name: 6-Chlorooxindole, 98%
Packaging: 5g
Price: $40.65
Updated: 2024/03/01

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6-Chlorooxindole Chemical Properties,Usage,Production

Preparation

STEP A: 3-(2-nitro-4-chlorophenyl)pyruvic acid To a cooled mixture prepared by adding 13.6 g. of sodium to 300 ml. of ethanol is added a solution of 100 g. of 4-chloro-2-nitrotoluene and 84 g of diethyloxalate in 150 ml of ethanol while maintaining the temperature below 20℃. The resulting mixture is refluxed for one hour, cooled, 400 ml. of water added and the resulting mixture refluxed for 90 minutes. The ethanol is then evaporated to a small volume and the resulting precipi tate containstan and black material and the black mate rial is mechanically separated and discarded and the remainder (filtrate plus tan precipitate) used in the next step. STEP B: 4-chloro-2-nitro-phenylacetic acid The filtrate of Step A, above, is adjusted to pH 8-9 with 2 N sodium hydroxide and is heated at 35-40℃. while adding a 3-6% aqueous hydrogen peroxide solution until samples no longer turn dark on treatment with 2N sodium hydroxide. The tan precipitate is suspended in 1500 ml of water, adjusted to pH 8-9 and similarly treated with aqueous hydrogen peroxide. The combined reaction mixtures are then acidified with concentrated hydrochloride acid to obtain a precipitate which are re covered by filtration, washed 3 times with water and dried in vacuo. The crude product (mp 145-150° C) is recrystallized from ether to obtain 4-chloro-2-nitro phenylacetic acid, m.p. 156-159℃. STEP C: The product of Step B, above, is subjected to reductive cyclization analogously to Step B of Example 1 to obtain 6-chloro-oxindole, m.p. 185-189℃.

Chemical Properties

Off-white to tan crystalline powder

Uses

6-Chlorooxindole is a useful research chemical used in the design of potent non-peptide MDM2 inhibitors.

Definition

ChEBI: 6-Chlorooxindole is a member of indoles.

Application

6-chlorooxyindole, also known as 6-chloro-2-indolone, is an intermediate of Ziprasidone hydrochloride. Ziprasidone is an atypical broad-spectrum antipsychotic developed by Pfizer for the treatment of schizophrenia with a strong affinity for serotonin and dopamine receptor antagonists, particularly the 5-HTA2/DAD2 receptor.

6-Chlorooxindole Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide N,N-Dimethylformamide Dimethyl malonate Acetic acid 2,5-Dichloronitrobenzene Iron Lithium chloride

Preparation Products

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6-Chlorooxindole Suppliers

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View Lastest Price from 6-Chlorooxindole manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 6-Chlorooxindole 56341-37-8
Price: US $999.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-22

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 6-Chlorooxindole 56341-37-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 500kg
Release date: 2022-12-13

Shanghai Yongzeng Technology Co.,Ltd

Product: 6-Chlorooxindole 56341-37-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 1000kgs
Release date: 2024-09-03

56341-37-8, 6-ChlorooxindoleRelated Search:

Indometacin Oxindole Chlorine dioxide Chlortalidone 1-(2,6-Dichlorophenyl)indolin-2-one Trazodone Zirconyl chloride octahydrate 3'-Chloroacetophenone Indole-3-acetic acid Chlormezanone Dihydromyrcenol 6-Chloroindole KETAMINE/ZYLAZINE SOLUTION--SCHEDULE*III ITEM 4,6-DICHLORO-1H-INDOLE-2,3-DIONE Ziprasidone hydrochloride monohydrate 6-Chloroisatin Ziprasidone HCl Difluorochloromethane

6-Chloro-2-oxoindole

6-Chloro-1,3-dihydro-2H-indol-

6-Chlorooxindole 98%

6-Chloro-2-oxindole in stock Factory

6-Chloro-2-oxindole / 6-Chloro-1,3-dihydro-indole 2-one

6-Chloro-1,3-dihydroindole-2-one

6-Chlorooxindole,98%

6-Chloro-1,3-dihvdro-indol-2-one

6-Chloro-2-oxindole 98%

6-chloro indole ketone

6-Chloroindolin-2-one, 6-Chloro-1,3-dihydro-2H-indol-2-one

1H-indol-6-yl hypochlorite

6-chloroindolin-2-one

2H-Indol-2-one,6-chloro-1,3-dihydro-

6-CHLOROINDOL-2(3H)-ONE

6-CHLOROOXINDOLE

6-CHLORO-2-OXOINDOLINE

6-CHLORO-2-OXINDOLE

6-CHLORO-2-INDOLINONE

6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE

6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

AKOS 207-09

LABOTEST-BB LT01147821

6-Chloroindole-2(3H)-one

6-Chlorooxindole &gt

6-Chloro-1,3,-dihydro-indol-2-on

6-Chlorooxindole 56341-37-8

Ziprasidone Impurity 19

Isatin Impurity 18

6-Chloroindole-2-one

6 -chloro oxi indole

6-CHLORO0XINDOLE

56341-37-8

563411-37-8

C8H6ClNO

C8H86ClNO

C8H6NOCI

Halogenated Heterocycles

Indoles

Heterocyclic Building Blocks

Building Blocks

Indoles and derivatives

Indole

Indoles

Heterocycles

Indole and Indoline

Starting Raw Materials & Intermediates

blocks

IndolesOxindoles

Indole/indoline/oxindole