ChemicalBook > CAS DataBase List > Moxonidine hydrochloride

Moxonidine hydrochloride

Product Name
Moxonidine hydrochloride
CAS No.
75438-58-3
Chemical Name
Moxonidine hydrochloride
Synonyms
BDF-5895 HCL;MOXONIDINE HCL;Moxoidine hydrochloride;MOXONIDINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;Moxonidine hydrochloride USP/EP/BP;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride
CBNumber
CB8686233
Molecular Formula
C9H13Cl2N5O
Formula Weight
278.14
MOL File
75438-58-3.mol
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Moxonidine hydrochloride Property

Melting point:
189°
CAS DataBase Reference
75438-58-3(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
UV6260290
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1559
Product name
Moxonidine hydrochloride
Purity
≥98%
Packaging
10MG
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
M1559
Product name
Moxonidine hydrochloride
Purity
≥98%
Packaging
25MG
Price
$285
Updated
2024/03/01
Usbiological
Product number
255893
Product name
Moxonidine hydrochloride
Packaging
10mg
Price
$403
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134877
Product name
Moxonidine hydrochloride
Purity
>99%
Packaging
100mg
Price
$510
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134877
Product name
Moxonidine hydrochloride
Purity
>99%
Packaging
250mg
Price
$606.9
Updated
2021/12/16
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Moxonidine hydrochloride Chemical Properties,Usage,Production

Description

Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.

Uses

Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM.

Application

Moxonidine hydrochloride has been used:
as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method.
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC).
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN).

Biological Activity

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.

Moxonidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Moxonidine hydrochloride Suppliers

China 99 Czech 1 Egypt 1 Europe 3 Switzerland 1 United Kingdom 2 United States 9 Global 116
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View Lastest Price from Moxonidine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Moxonidine hydrochloride 75438-58-3
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
97.5%-102% HPLC;EP
Supply Ability
10KGS
Release date
2021-11-08
Shaanxi Dideu Medichem Co. Ltd
Product
Moxonidine hydrochloride 75438-58-3
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09
Career Henan Chemical Co
Product
Moxonidine hydrochloride 75438-58-3
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-10

75438-58-3, Moxonidine hydrochlorideRelated Search:

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  • MOXONIDINE HYDROCHLORIDE
  • MOXONIDINE HCL
  • BDF-5895 HCL
  • 4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL
  • 4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
  • MoxonidineHclC9H12C1N50.HC1
  • 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-3H-pyrimidin-2-amine hydrochloride
  • 6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride
  • BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride
  • Moxonidine hydrochloride USP/EP/BP
  • Moxoidine hydrochloride
  • 75438-58-3
  • C9H14ClN5OHCl
  • C9H13Cl2N5O
  • C9H12ClN5OHCl
  • Imidazoline binding site
  • Antihypertensive