ChemicalBook > CAS DataBase List > Moxonidine hydrochloride

Moxonidine hydrochloride

Product Name: Moxonidine hydrochloride
CAS No.: 75438-58-3
Chemical Name: Moxonidine hydrochloride
Synonyms: BDF-5895 HCL;MOXONIDINE HCL;Moxoidine hydrochloride;MOXONIDINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;Moxonidine hydrochloride USP/EP/BP;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride
CBNumber: CB8686233
Molecular Formula: C9H13Cl2N5O
Formula Weight: 278.14
MOL File: 75438-58-3.mol

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Moxonidine hydrochloride Property

Melting point:: 189°
InChI: InChI=1S/C9H14ClN5O.ClH/c1-9(15-8-11-3-4-12-8)13-6(10)5-7(14-9)16-2;/h5,13H,3-4H2,1-2H3,(H2,11,12,15);1H
InChIKey: SKWXZGXGBKLLOD-UHFFFAOYSA-N
SMILES: C1(C)(NC2NCCN=2)N=C(OC)C=C(Cl)N1.[H]Cl
CAS DataBase Reference: 75438-58-3(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: UV6260290

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M1559
Product name: Moxonidine hydrochloride
Purity: ≥98%
Packaging: 10MG
Price: $125
Updated: 2025/07/31

Sigma-Aldrich

Product number: M1559
Product name: Moxonidine hydrochloride
Purity: ≥98%
Packaging: 25MG
Price: $249
Updated: 2025/07/31

Usbiological

Product number: 255893
Product name: Moxonidine hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134877
Product name: Moxonidine hydrochloride
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134877
Product name: Moxonidine hydrochloride
Purity: >99%
Packaging: 250mg
Price: $606.9
Updated: 2021/12/16

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Moxonidine hydrochloride Chemical Properties,Usage,Production

Description

Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.

Uses

Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM.

Application

Moxonidine hydrochloride has been used:
as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method.
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC).
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN).

Biological Activity

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.

Moxonidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Moxonidine hydrochloride Suppliers

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View Lastest Price from Moxonidine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Moxonidine hydrochloride 75438-58-3
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97.5%-102% HPLC;EP
Supply Ability: 10KGS
Release date: 2021-11-08

Shaanxi Dideu Medichem Co. Ltd

Product: Moxonidine hydrochloride 75438-58-3
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

Career Henan Chemical Co

Product: Moxonidine hydrochloride 75438-58-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-10

75438-58-3, Moxonidine hydrochlorideRelated Search:

Imidazolidine Anisole Cinchonidine Tizanidine Ramosetron hydrochloride (Trifluoromethoxy)benzene Fexofenadine hydrochloride Propacetamol Topotecan hydrochloride Methylparaben Clonidine hydrochloride Dihydromyrcenol 2-Methoxyethanol Methanol Methyl acrylate Tribenuron methyl Imidazole Methyl

MOXONIDINE HYDROCHLORIDE

MOXONIDINE HCL

BDF-5895 HCL

4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL

4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE

MoxonidineHclC9H12C1N50.HC1

4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-3H-pyrimidin-2-amine hydrochloride

6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride

BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride

Moxonidine hydrochloride USP/EP/BP

Moxoidine hydrochloride

75438-58-3

C9H14ClN5OHCl

C9H13Cl2N5O

C9H12ClN5OHCl

Imidazoline binding site

Antihypertensive