Moxonidine hydrochloride
- Product Name
- Moxonidine hydrochloride
- CAS No.
- 75438-58-3
- Chemical Name
- Moxonidine hydrochloride
- Synonyms
- BDF-5895 HCL;MOXONIDINE HCL;Moxoidine hydrochloride;MOXONIDINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;Moxonidine hydrochloride USP/EP/BP;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride
- CBNumber
- CB8686233
- Molecular Formula
- C9H13Cl2N5O
- Formula Weight
- 278.14
- MOL File
- 75438-58-3.mol
Moxonidine hydrochloride Property
- Melting point:
- 189°
- CAS DataBase Reference
- 75438-58-3(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- UV6260290
N-Bromosuccinimide Price
- Product number
- M1559
- Product name
- Moxonidine hydrochloride
- Purity
- ≥98%
- Packaging
- 10MG
- Price
- $143
- Updated
- 2024/03/01
- Product number
- M1559
- Product name
- Moxonidine hydrochloride
- Purity
- ≥98%
- Packaging
- 25MG
- Price
- $285
- Updated
- 2024/03/01
- Product number
- 255893
- Product name
- Moxonidine hydrochloride
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- orb134877
- Product name
- Moxonidine hydrochloride
- Purity
- >99%
- Packaging
- 100mg
- Price
- $510
- Updated
- 2021/12/16
- Product number
- orb134877
- Product name
- Moxonidine hydrochloride
- Purity
- >99%
- Packaging
- 250mg
- Price
- $606.9
- Updated
- 2021/12/16
Moxonidine hydrochloride Chemical Properties,Usage,Production
Description
Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Uses
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM.
Application
Moxonidine hydrochloride has been used:
as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method.
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC).
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN).
Biological Activity
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Moxonidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Moxonidine hydrochloride Suppliers
View Lastest Price from Moxonidine hydrochloride manufacturers
- Product
- Moxonidine hydrochloride 75438-58-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 97.5%-102% HPLC;EP
- Supply Ability
- 10KGS
- Release date
- 2021-11-08
- Product
- Moxonidine hydrochloride 75438-58-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- Moxonidine hydrochloride 75438-58-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09