ChemicalBook > CAS DataBase List > 4-Chloropyridine-3-carboxaldehyde
4-Chloropyridine-3-carboxaldehyde
- Product Name
- 4-Chloropyridine-3-carboxaldehyde
- CAS No.
- 114077-82-6
- Chemical Name
- 4-Chloropyridine-3-carboxaldehyde
- Synonyms
- 4-Chloronicotinaldehyde;4-CHLORO-3-FORMYLPYRIDINE;4-chloro-3-pyridylazaldehyde;4-chloropyridin-3-carbaldehyde;4-chloropyridine-3-carbaldehyde;4-chloro-3-pyridinecarbaldehyde;4-chloro-3-pyridincarboxaldehyde;4-Chloro-3-pyridinecarboxaldehyde;4-CHLOROPYRIDINE-3-CARBOXALDEHYDE;4-Chhloropyridine-3-carboxaldehyde
- CBNumber
- CB8687487
- Molecular Formula
- C6H4ClNO
- Formula Weight
- 141.56
- MOL File
- 114077-82-6.mol
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4-Chloropyridine-3-carboxaldehyde Property
- Boiling point:
- 228.8±20.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 1.89±0.10(Predicted)
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C6H4ClNO/c7-6-1-2-8-3-5(6)4-9/h1-4H
- InChIKey
- DYRMBQRXOMOMNW-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(Cl)=C1C=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C381278
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
TRC
- Product number
- C381278
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
TRC
- Product number
- C381278
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 070118
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC55551
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
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4-Chloropyridine-3-carboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
White to light yellow powder
Synthesis
626-61-9
68-12-2
114077-82-6
General procedure: a tetrahydrofuran solution (50 ml) of 4-chloropyridine (25.0 g, 0.22 mol) was slowly added dropwise to a solution of diisopropylammonium lithium prepared from a hexane solution of 1.6 M n-butyllithium (179 ml, 0.29 mol) with diisopropylamine (33.4 g, 0.33 mol) in tetrahydrofuran (300 ml) under the protection of argon gas, keeping the reaction temperature at -78°C. After dropwise addition, stirring was continued for 30 min. Subsequently, N,N-dimethylformamide (DMF, 19.3 g, 0.26 mol) was added and the reaction mixture was gradually warmed up to room temperature. After completion of the reaction, extraction was carried out with ethyl acetate (200 ml) and 5% aqueous ammonium chloride solution (300 ml). The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude product 4-chloro-3-pyridinecarboxaldehyde (27 g, 86% yield) as an oil. The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 7.45 (1H, d, J = 5.0 Hz), 8.69 (1H, d, J = 5.0 Hz), 9.05 (1H, s), 10.51 (1H, s).
References
[1] Patent: EP1348706, 2003, A1. Location in patent: Page/Page column 37
[2] Patent: US2011/53975, 2011, A1. Location in patent: Page/Page column 60
[3] Journal of the American Chemical Society, 2013, vol. 135, # 40, p. 14916 - 14919
[4] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 44
[5] Patent: WO2004/41806, 2004, A2. Location in patent: Page 88-89
4-Chloropyridine-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Nitrogen
Ethyl formate
Sodium sulfate
Sodium
Diisopropylamine
Tetrahydrofuran
Ethyl acetate
Methanol
4-Chloropyridinium chloride
n-Butyllithium
Preparation Products
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View Lastest Price from 4-Chloropyridine-3-carboxaldehyde manufacturers
PNP Biotech Co. Ltd
- Product
- 4-Chloropyridine-3-carboxaldehyde 114077-82-6
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-10
Dideu Industries Group Limited
- Product
- 4-Chloropyridine-3-carboxaldehyde 114077-82-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
Career Henan Chemical Co
- Product
- 4-Chloropyridine-3-carboxaldehyde 114077-82-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14
114077-82-6, 4-Chloropyridine-3-carboxaldehydeRelated Search:
Chlorosulfonyl isocyanate
Pentachloropyridine
MCPA SODIUM
N-Chlorosuccinimide
2-Chloro-5-chloromethylpyridine
3-Aminopyridine
Clopidol
2-Chloro-3-cyanopyridine
3-Hydroxypyridine
4-Chloropyridinium chloride
4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
4-Chloronicotinic acid
ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE
4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBONYL CHLORIDE
5-CHLORO-2-FORMYLPYRIDINE
5-Chloropyridine-3-carboxaldehyde
3-CHLOROPYRIDINE-4-CARBOXALDEHYDE
2-CHLOROPYRIDINE-3-CARBOXALDEHYDE,2-Chloropyridine-3-carboxaldehyde, 2-Chloro-3-formylpyridine