ChemicalBook > CAS DataBase List > L-Alaninol

L-Alaninol

Product Name
L-Alaninol
CAS No.
2749-11-3
Chemical Name
L-Alaninol
Synonyms
L-ALANINOL;2-AMINOPROPANOL;H-ALA-OL;310399;L-2-Amino-1-propanol;(S)-2-AMINO-1-PROPANOL;L-Ala-ol;L-Alanino;L-ALANILOL;H-ALANINOL
CBNumber
CB8693194
Molecular Formula
C3H9NO
Formula Weight
75.11
MOL File
2749-11-3.mol
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L-Alaninol Property

Melting point:
-2°C
Boiling point:
72-73 °C11 mm Hg(lit.)
alpha 
21.8 º (c=2,ethanol)
Density 
0.965 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.450
Flash point:
145 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Water Solubility 
Completely miscible in water
solubility 
Chloroform, Methanol (Slightly)
pka
12.88±0.10(Predicted)
form 
Oily Liquid
color 
Clear colorless to yellow
Specific Gravity
0.96
optical activity
[α]20/D +18°, neat
Sensitive 
Hygroscopic
BRN 
1718865
CAS DataBase Reference
2749-11-3(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanol, 2-amino-, (S)-(2749-11-3)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
F 
10-23
HazardClass 
8
PackingGroup 
III
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A76206
Product name
(S)-(+)-2-Amino-1-propanol
Purity
98%
Packaging
1g
Price
$47.2
Updated
2024/03/01
Sigma-Aldrich
Product number
A76206
Product name
(S)-(+)-2-Amino-1-propanol
Purity
98%
Packaging
10g
Price
$293
Updated
2024/03/01
TCI Chemical
Product number
A1085
Product name
(S)-(+)-2-Amino-1-propanol
Purity
>98.0%(GC)(T)
Packaging
1mL
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
A1085
Product name
(S)-(+)-2-Amino-1-propanol
Purity
>98.0%(GC)(T)
Packaging
5mL
Price
$93
Updated
2024/03/01
Alfa Aesar
Product number
B24916
Product name
(S)-(+)-2-Amino-1-propanol, 98%
Packaging
5g
Price
$108.65
Updated
2024/03/01
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L-Alaninol Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

S-(+)-2-Amino-1-propanol is an aliphatic amino alcohol shown to induce an antiproliferative effect in B16 melanoma cells. S-(+)-2-Amino-1-propanol is used in the preparation of oxazolines which are of ten used as ligands in homogeneous catalysis.

Uses

(S)-(+)-2-Amino-1-propanol (L-Alaninol) may be used in the preparation of unsymmetrical tridentate Schiff base ligands via condensation with carbonyl compounds. It may also be used as a chiral auxillary for the preparation of tert-butyl 4-N-[(2-hydroxy-1-(S)-methyl)ethylamino]-2-methylene-4-(S)-phenyl-butyrate.

Definition

ChEBI: An amino alcohol that is L-alanine in which the carboxy group has been reduced to the corresponding alcohol.

Biochem/physiol Actions

Pseudomonas sp. strain KIE171 was able to grow with L-alaninol [S-(+)-2-amino-1-propanol] as the sole carbon source[1]. W?sch et al. found that mutant KIE171-BI transformed isopropylamine to L-alaninol, mutant KIE171-BII failed to do so.

Synthesis

Simply produce L-alaninol in high yield and good reproducibility by directly reducing an inorganic acid salt of an L-alanine ester with NaBH4. 3.0 mol of NaBH 4 was added and dissolved in 560 ml of cold water, and L-alanine ethyl ester hydrochloride 1. A solution of 0 mol dissolved in 560 ml of ethanol was added. The mixture was added dropwise at 20 ° C. over 5 hours and further aged at 20 to 28 ° C. to complete the reaction. After the reaction, excess NaBH 4 was decomposed with acetone, 1000 ml of ethyl acetate was introduced, and the precipitated inorganic substance was separated by filtration. The lower aqueous layer portion of the filtrate was extracted with 600 ml of ethyl acetate; the ethyl acetate layer was distilled under reduced pressure to remove the solvent and then vacuum distilled to yield L-alaninol.

Purification Methods

Purify it as for S-2-amino-3-methylbutan-1-ol below. [Beilstein 4 IV 1615.]

References

[1] Susana I de Azevedo W?sch. “Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates.”Applied and Environmental Microbiology (2002): 68.

L-Alaninol Preparation Products And Raw materials

Raw materials

L-Alanine

Preparation Products

1-AdaMantanethylaMine
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L-Alaninol Suppliers

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View Lastest Price from L-Alaninol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-Ala-ol 2749-11-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-14
Baoji Guokang Bio-Technology Co., Ltd.
Product
S-(+)-2-Amino-1-propano 2749-11-3
Price
US $125.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2021-06-07
Shandong Yanshuo Chemical Co., Ltd.
Product
L-Alaninol 2749-11-3
Price
US $0.00-0.00/kg
Min. Order
25kg
Purity
≥98%(HPLC,min.)
Supply Ability
10Tons
Release date
2022-11-21

2749-11-3, L-AlaninolRelated Search:

ALTRENOGEST Glycine 2-Amino-2-methyl-1-propanol Betaine EC 2.6.1.2 1-Propanol Glucosamine Acetaminophen Sulfamic acid Aminopyrine Isopropyl alcohol 3-Dimethylamino-1-propanol (S)-2-AMINO-PROPAN-1-OL,DL-2-Amino-1-propanol;DL-Alaninol; DL-Alaninol ,DL-ALANINOL FREE BASE Ethyl N-benzoyl-L-tyrosinate Ethyl N-acetyl-L-tyrosinate hydrate 3-Aminopropanol TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE (±)-1-amino-propan-2-o

  • H-L-ALA-OL
  • H-ALANINOL
  • H-ALA-OL
  • H-ALA-OL S-(+)-2 AMINO-PROPANOL
  • 2-AMINOPROPANOL
  • L-(+)-ALANINOL
  • L-ALANINOL
  • L-ALANILOL
  • L-(+)-2-AMINO PROPANOL
  • L-2-AMINO-PROPANOL
  • L-Alaninols-(+)-2-amino propanol
  • (2S)-(+)-2-Aminopropan-1-ol
  • L-Alaninol, (2S)-(+)-2-Amino-1-hydroxypropane
  • L-Alaninol SynonyMs: (S)-(+)-2-AMino-1-propanol
  • (S)-(+)-2-AMino-1-propanol 98%
  • 2-(2-AMinoethyl)-1,3-dioxolane, 98.0%(GC&T
  • L-Alanino
  • 310399
  • (S)-(+)-2-AMino-1-propanol, 98% 1GR
  • L-2-Amino-1-propanol
  • L-Alaninol≥ 99.9% (GC, Chiral purity)
  • L-Alaninol,99%e.e.
  • (S)-(+)-2-AMINO-1-PROPANOL
  • (S)-2-AMINO-1-PROPANOL
  • (S)-2-AMINO-PROPAN-1-OL
  • L-Alaninol,98+%
  • L-Alaninol (L-2-Amino-1-propanol)
  • (+)-2-Aminopropan-1-ol
  • (S)-(+)-Alaninol
  • Aminopropanol,95%
  • (S)-(+)-2-AMINO-1-PROPANOL, 98% (97% EE/
  • L-Alaninol(L-2-Amino-Propanol)
  • L-Ala-ol
  • VL-Alaninol
  • S-(+)-ALANINOL:L-ALANINOL
  • (S)-(+)-2-Amino-1-propanol,98%
  • S-(+)-2-Alaninol (L-
  • [(2S)-1-hydroxypropan-2-yl]ammonium
  • (S)-(+)-2-Amino-1-propanol &gt
  • 1-Propanol, 2-amino-, (2S)-
  • (S)-(+)-2-AMINO-L-PROPANOL
  • S-(+)-2-Amino-1-propanol USP/EP/BP
  • L-Alaninol, 98% [(S)-(+)-2-Amino-1-propanol]
  • Pirimicarb Impurity 5 (Pirimiphos Ethyl)
  • 2749-11-3
  • 2749-11-2
  • 11/3/2749
  • 2749-11-03
  • 27-49-1
  • C3H9NO
  • Building Blocks
  • Amino Acid Derivatives
  • Chiral Resolution Reagents
  • Chiral Resolving Reagents
  • Organic Building Blocks
  • Specialty Synthesis
  • Oxygen Compounds
  • Peptide Synthesis