Imipenem
Chemical Properties Discovery Broad-spectrum antibiotic- Product Name
- Imipenem
- CAS No.
- 74431-23-5
- Chemical Name
- Imipenem
- Synonyms
- Imipenem Monohydrate≥ 96% (HPLC);CS-342;MK-0787;Imipenem;lmipemide;EOS-61603;Imipenem（b）;Imipenem hydrate;Tienam monohydrate;Imipenem n-Hydrate
- CBNumber
- CB8695769
- Molecular Formula
- C12H19N3O5S
- Formula Weight
- 317.36
- MOL File
- 74431-23-5.mol
Imipenem Property
- Melting point:
- 193-198°C
- Boiling point:
- 567℃
- RTECS
- CL5446516
- Flash point:
- >110°(230°F)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O: >5mg/mL
- pka
- pKa 3.2/9.9(H2O,t = 25) (Uncertain)
- form
- powder
- color
- white to beige
- Water Solubility
- Soluble in water at 5mg/ml
- CAS DataBase Reference
- 74431-23-5(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 2941906000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- I0160
- Product name
- Imipenem monohydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $137.6
- Updated
- 2024/03/01
- Product number
- I0160
- Product name
- Imipenem monohydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $682
- Updated
- 2024/03/01
- Product number
- I0090000
- Product name
- Imipenem
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- I0090000
- Price
- $153
- Updated
- 2024/03/01
- Product number
- J66749
- Product name
- Imipenem monohydrate, 95%
- Packaging
- 5mg
- Price
- $97.65
- Updated
- 2024/03/01
- Product number
- J66749
- Product name
- Imipenem monohydrate, 95%
- Packaging
- 25mg
- Price
- $247
- Updated
- 2024/03/01
Imipenem Chemical Properties,Usage,Production
Chemical Properties
Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. Its chemical name is (5 R,6S)-3-[[2-(formimidoylamino)ethyl]thio]-6-[( R)-1-hydroxyethyl ]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate. It is an off-white, nonhygroscopic crystalline compound with a molecular weight of 317.37. It is sparingly soluble in water and slightly soluble in methanol.
Discovery
Broad-spectrum antibiotic
Chemical Properties
Off-White Solid
Uses
antiulcer
Uses
antidiabetic
Uses
Imipenem has a broad spectrum of antimicrobial action, which includes most clinically
significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is
resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for bacterial infections of the lower respiratory tract, infections of the urinary
and sexual tracts, infections of bones, joints, skin, soft tissues, intraabdominal and gynecological infections, bacterial septicemia, and endocarditis.
Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem,
it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2-
amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid
(32.1.3.6), which inhibits metabolisms of imipenem in the kidneys. This combination of two
compounds is also used in medicine under the name primaxin.
Uses
An extremely broad-spectrum semi-synthetic antibiotic
Definition
ChEBI: Imipenem hydrate is a member of carbapenems. It contains an imipenem.
General Description
Chemical structure: ?-lactam
Biochem/physiol Actions
Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.
Synthesis
Imipenem, [5R-[5|á,6|á(R)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino] ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-2-carboxylic acid (32.1.3.1), is the only carbapenem presently used in clinics. It is synthesized from thienamycin isolated from Streptomyces cattleya by reacting it with the methyl formimidate.
Unlike penicillins and cephalosporins, which have a side aminoacyl group joined to the betalactam ring, imipenem has a |á-hydroxyethyl side chain. Significant resistance to hydrolysis by beta-lactamases is observed in this compound, evidently thanks to the trans-configuration of the side chain, while the side chain of penicillins and cephalosporins have a cis configuration.
Imipenem Preparation Products And Raw materials
Raw materials
Preparation Products
Imipenem Suppliers
- Tel
- --
- Fax
- --
- biuro@pol-aura.pl
- Country
- Poland
- ProdList
- 1453
- Advantage
- 58
View Lastest Price from Imipenem manufacturers
- Product
- Imipenem 74431-23-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 1000
- Release date
- 2024-05-29
- Product
- Imipenem 74431-23-5
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-07
- Product
- Imipenem 74431-23-5
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-06