DIMETHISTERONE Property

Melting point:

102°

alpha 

D20 +10° (c = 1 in chloroform)

Boiling point:

416.28°C (rough estimate)

Density 

1.0555 (rough estimate)

refractive index 

1.4480 (estimate)

pka

13.03±0.70(Predicted)

EPA Substance Registry System

Dimethisterone (79-64-1)

Hazard and Precautionary Statements (GHS)

DIMETHISTERONE Chemical Properties,Usage,Production

Originator

Oracon,Mead Johnson,US,1965

Uses

Dimethisterone-d3 is the labeled analogue of Dimethisterone (D460430), an oral contraceptive steroid.

Definition

ChEBI: Dimethisterone is a 3-hydroxy steroid. It has a role as an androgen.

Manufacturing Process

A solution of a Grignard reagent, employing 1-propyne (8 grams) was prepared. To this reagent there was added the 3,3 ethylenedioxy derivative (4 grams) of 6-α-methylandrost-4-ene-3,17-dione in tetrahydrofuran (100 ml), and the mixture heated under reflux for 3 hours. After decomposition of the complex with aqueous ammonium chloride, the product was isolated with ether and treated with 90% acetic acid (50 ml) for 30 minutes at 100°C. The product obtained by pouring the mixture into water and extracting with ether was crystallized from aqueous methanol. 17β-Hydroxy-6α-methyl-17α-(prop- 1-ynyl)androst-4-en-3-one formed plates MP 99° to 102°C.

Therapeutic Function

Progestin