N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Product Name: N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
CAS No.: 51116-00-8
Chemical Name: N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
Synonyms: DB-cGMP;DBCGMP NA;DIBUTYRYL-CGMP;Bt2cGMP sodium;DIBUTYRYL-CGMP NA;DB-CGMP SODIUM SALT;Dibutyryl-cGMP sodium;N2,2'-O-Dibutyryl cGMP;DIBUTYRYL-CGMP SODIUM SALT;MGBPJXVWDGGLKI-GBIKJYCISA-M
CBNumber: CB8704951
Molecular Formula: C18H23N5NaO9P
Formula Weight: 507.37
MOL File: 51116-00-8.mol

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N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Property

storage temp.: −20°C
solubility: H₂O: 50 mg/mL
form: powder
color: off-white

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Safety

WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 370660
Product name: Guanosine 3?,5?-cyclic Monophosphate, N2,2?-O-Dibutyryl-, Sodium Salt
Packaging: 10mg
Price: $135
Updated: 2025/07/31

Cayman Chemical

Product number: 15991
Product name: Dibutyryl-Cyclic GMP (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 15991
Product name: Dibutyryl-Cyclic GMP (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $114
Updated: 2024/03/01

Cayman Chemical

Product number: 15991
Product name: Dibutyryl-Cyclic GMP (sodium salt)
Purity: ≥98%
Packaging: 50mg
Price: $398
Updated: 2024/03/01

TRC

Product number: D493780
Product name: Dibutyryl-cGMP
Packaging: 10mg
Price: $85
Updated: 2021/12/16

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N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Chemical Properties,Usage,Production

Description

Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase. It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.

Uses

Dibutyryl-cGMP is a membrane permeable cGMP analog.

in vivo

Dibutyryl-cGMP (50-200?μg/paw; subcutaneous injection; male Wistar rats) treatment antagonizes the hyperalgesic effect of PGE2 in a dose-dependent manner. Maximal antinociceptive effect of DbcGMP is at 1?h after administration and last for plus 2?h^[3].

Animal Model:	Male Wistar rats (180-?250?g) injection with Prostaglandin E2 (PGE2)^[3]
Dosage:	50 μg/paw, 75 μg/paw, 100 μg/paw and 200?μg/paw
Administration:	Subcutaneous injection
Result:	Antagonized the hyperalgesic effect of PGE2 (2?μg/paw), in a dose-dependent manner.

References

[1] M. CATALDI . Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells[J]. Biochimica et biophysica acta. Molecular cell research, 1999, 1449 2: Pages 186-193. DOI: 10.1016/s0167-4889(99)00013-0
[2] NICHOLAS J. WILLMOTT Antony G Judith Asselin. Calcium store depletion potentiates a phosphodiesterase inhibitor- and dibutyryl cGMP-evoked calcium influx in rat pituitary GH3 cells[J]. FEBS Letters, 1996, 386 1: 39-42. DOI: 10.1016/0014-5793(96)00413-9
[3] S S KAPLAN. Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP.[J]. Blood, 1989, 74 6: 1885-1887.
[4] C. CHIK. cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes[J]. Journal of Neuroscience, 1995, 2 1: 3104-3109. DOI: 10.1523/jneurosci.15-04-03104.1995
[5] T A ROONEY. Cyclic GMP induces oscillatory calcium signals in rat hepatocytes.[J]. The Journal of Biological Chemistry, 1996, 271 33: 19817-19825. DOI: 10.1074/jbc.271.33.19817

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Suppliers

China 36 Germany 2 Japan 1 Switzerland 2 United Kingdom 2 United States 16 Global 59

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51116-00-8, N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALTRelated Search:

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Sodium phosphate monobasic AICAR Ganciclovir N2-METHYLGUANOSINE 1-METHYL-1H-IMIDAZOLE-4-CARBALDEHYDE 2'-O-Methylguanosine 2',3'-Dideoxyguanosine Guanine Inosine 2'-Deoxyinosine N-2-Acetylguanine Guanosine N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE 2'-O-MB-CGMP SODIUM SALT 9-(3,4-dihydroxybutyl)guanine N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Acyclovir, Monophosphate

MGBPJXVWDGGLKI-GBIKJYCISA-M

dibutyryl cyclic 3',5'-guanosine monophosphate, sodium

N2,2μ-O-Dibutyrylguanosine 3μ,5μ-cyclic monophosphate hydrate sodium salt

Guanosine 3,5-cyclic Monophosphate, N2,2-O-Dibutyryl-, Sodium Salt - CAS 51116-00-8 - Calbiochem

N2,2μ-O-Dibutyrylguanosine 3μ,5μ-cyclic monophosphate dihydrate sodium salt

N,2'-O-Dibutyrylguanosine 3',5'-phosphoric acid

N2,2'-O-Dibutyryl cGMP

Dibutyryl-Cyclic GMP (sodium salt)

n2,2’-o-dibutyrylguanosine-3’,5’-cyclicmonophosphate(dbcgmp),sodiumsalt

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N2,2'-O-DIBUTYRYLGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N2-2''-O-Dibutyrylguanosine-3'',5''-cyclic monophosphoric acid

GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, N2,2'-O-DIBUTYRYL-, SODIUM SALT

DBCGMP NA

DB-CGMP SODIUM SALT

DIBUTYRYL-CGMP

DIBUTYRYL-CGMP NA

DIBUTYRYL-CGMP SODIUM SALT

Guanosine, 3,5-cyclic Monophosphate, N2,2-O-Dibutyryl-,

N2,2-O-Dibutyrylguanosine 3,5-cyclic monophosphate sodium salt dihydrate

N2,2'-O-dibutyrylguanosine-3',5'-cyclo-phos. so-sa. dihyd.

Guanosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSPH

N2 2'-O-DIBUTYRYLGUANOSINE-3' 5'-CYCLO-&

Bt2cGMP sodium

Dibutyryl-cGMP sodium

DB-cGMP

DibutyrylcGMP sodium,Dibutyryl cGMP sodium

N2,2'-O-DIBUTYRYLGUANOSINE 3':5'-CYCLIC MONOPHOSP...

Dibutyryl-cGMP, cGMP analog

51116-00-8

C18H23N5NaO9P

C18H23N5NaO9P2H2O

C18H24N5NaO9P

Nucleotide Analogs

Nucleosides, Nucleotides, Oligonucleotides

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide Metabolism

Cyclic Nucleotides and Analogs

Biochemicals and Reagents

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Biochemicals and Reagents

Nucleosides, Nucleotides, Oligonucleotides

Nucleotide Analogs

Cyclic Nucleotide Metabolism

Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology

G Proteins and Cyclic Nucleotides

Protein Kinase G (PKG)

Serine/Threonine Kinase Activators