ChemicalBook > CAS DataBase List > 2'-O-Methylguanosine

2'-O-Methylguanosine

Product Name
2'-O-Methylguanosine
CAS No.
2140-71-8
Chemical Name
2'-O-Methylguanosine
Synonyms
OMe-rG;2'-OMe-G;2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe-Gr;2'-OMe Guanosine;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methylguanosine
CBNumber
CB2276641
Molecular Formula
C11H15N5O5
Formula Weight
297.27
MOL File
2140-71-8.mol
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2'-O-Methylguanosine Property

Melting point:
227-231°C (dec.)
Density 
1.98±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Aqueous Base (Slightly), DMSO (Slightly),
pka
9?+-.0.20(Predicted)
form 
Powder
color 
White to Off-white
λmax
256 (pH 1);258 (pH 11)
InChI
InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey
OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES
OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference
2140-71-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-22
Safety Statements 
26-36-60-36/37
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2318
Product name
2'-O-Methylguanosine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$280
Updated
2024/03/01
TCI Chemical
Product number
M2318
Product name
2'-O-Methylguanosine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
J65770
Product name
2'-O-Methylguanosine, 99%
Packaging
1g
Price
$82.4
Updated
2024/03/01
Alfa Aesar
Product number
J65770
Product name
2'-O-Methylguanosine
Purity
99%
Packaging
250mg
Price
$20.2
Updated
2021/12/16
Cayman Chemical
Product number
21039
Product name
2'-O-Methylguanosine
Purity
≥98%
Packaging
250mg
Price
$57
Updated
2024/03/01
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2'-O-Methylguanosine Chemical Properties,Usage,Production

Description

2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-Methylguanosine Suppliers

Zhengzhou Chemprize Biotech Co., Ltd.
Tel
15981919713
Email
sales@chemprize.com
Country
China
ProdList
408
Advantage
58
Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Fax
+86-25-58356858
Email
sales@unisyn.cn
Country
China
ProdList
561
Advantage
58
Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-8233716 18055326116
Email
kendoll@cqpharm.com
Country
China
ProdList
645
Advantage
58
Jiangsu Synthgene Biotechnology Co.,Ltd.
Tel
18136497538
Email
znf@syngenebio.com
Country
China
ProdList
901
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Shandong utilizing biological technology co., LTD
Tel
15966937598
Fax
3407640895 3071519937
Email
3407650895@qq.com
Country
China
ProdList
1240
Advantage
58
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
Advantage
64
HeFei ShenShen Medical Technology Co.,Ltd
Tel
15375050680; 15375050680
Email
gdz2.71828@163.com
Country
China
ProdList
17
Advantage
58
Allbiosyn Biotechnology Co.,LTD
Tel
18666985712
Email
info@allbiosyn.com
Country
China
ProdList
286
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from 2'-O-Methylguanosine manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
2'-O-Methylguanosine 2140-71-8
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
100kg
Release date
2023-05-10
Yunbio Tech Co.,Ltd.
Product
2'-O-Methylguanosine 2140-71-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
300KG per month
Release date
2023-03-04
Zhejiang Hengkang Pharmaceutical Co., Ltd.
Product
2'-O-Methylguanosine 2140-71-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg per month
Release date
2022-12-27

2140-71-8, 2'-O-MethylguanosineRelated Search:


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  • Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA
  • 2 '- Methoxyguanosine
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  • 2'- 0 -Methylguanosine
  • OMe-rG
  • 2140-71-8
  • C11H15N5O5xH2O
  • C11H15N5O5H2O
  • Nucleotides
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleosides
  • Modified(deoxy)nucleoside
  • Nucleosides-2'-OMe Nucleosides