2'-O-Methylguanosine
- Product Name
- 2'-O-Methylguanosine
- CAS No.
- 2140-71-8
- Chemical Name
- 2'-O-Methylguanosine
- Synonyms
- OMe-rG;2'-OMe-G;2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe-Gr;2'-OMe Guanosine;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methylguanosine
- CBNumber
- CB2276641
- Molecular Formula
- C11H15N5O5
- Formula Weight
- 297.27
- MOL File
- 2140-71-8.mol
2'-O-Methylguanosine Property
- Melting point:
- 227-231°C (dec.)
- Density
- 1.98±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Aqueous Base (Slightly), DMSO (Slightly),
- pka
- 9?+-.0.20(Predicted)
- form
- Powder
- color
- White to Off-white
- λmax
- 256 (pH 1);258 (pH 11)
- InChI
- InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
- InChIKey
- OVYNGSFVYRPRCG-KQYNXXCUSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
- CAS DataBase Reference
- 2140-71-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-60-36/37
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2318
- Product name
- 2'-O-Methylguanosine Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $280
- Updated
- 2024/03/01
- Product number
- M2318
- Product name
- 2'-O-Methylguanosine Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- J65770
- Product name
- 2'-O-Methylguanosine, 99%
- Packaging
- 1g
- Price
- $82.4
- Updated
- 2024/03/01
- Product number
- J65770
- Product name
- 2'-O-Methylguanosine
- Purity
- 99%
- Packaging
- 250mg
- Price
- $20.2
- Updated
- 2021/12/16
- Product number
- 21039
- Product name
- 2'-O-Methylguanosine
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2024/03/01
2'-O-Methylguanosine Chemical Properties,Usage,Production
Description
2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.
Chemical Properties
White Solid
Uses
Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
Definition
ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.
Synthesis
8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.
2'-O-Methylguanosine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2'-O-Methylguanosine manufacturers
- Product
- 2'-O-Methylguanosine 2140-71-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-05-10
- Product
- 2'-O-Methylguanosine 2140-71-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 300KG per month
- Release date
- 2023-03-04
- Product
- 2'-O-Methylguanosine 2140-71-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg per month
- Release date
- 2022-12-27