2'-O-Methylguanosine

Product Name: 2'-O-Methylguanosine
CAS No.: 2140-71-8
Chemical Name: 2'-O-Methylguanosine
Synonyms: OMe-rG;2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe Guanosine;2′,-O-Me-Guo;2'-O-Methylguanosine;2'-O-Methylguanosine;2 '- Methoxyguanosine;2'- 0 -Methylguanosine
CBNumber: CB2276641
Molecular Formula: C11H15N5O5
Formula Weight: 297.27
MOL File: 2140-71-8.mol

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2'-O-Methylguanosine Property

Melting point:: 227-231°C (dec.)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Aqueous Base (Slightly), DMSO (Slightly),
pka: 9?+-.0.20(Predicted)
form: Powder
color: White to Off-white
λmax: 256 (pH 1)；258 (pH 11)
InChI: InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey: OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES: OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference: 2140-71-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-22
Safety Statements: 26-36-60-36/37
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2318
Product name: 2'-O-Methylguanosine Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $252
Updated: 2025/07/31

TCI Chemical

Product number: M2318
Product name: 2'-O-Methylguanosine Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $80
Updated: 2025/07/31

Cayman Chemical

Product number: 21039
Product name: 2'-O-Methylguanosine
Purity: ≥98%
Packaging: 250mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21039
Product name: 2'-O-Methylguanosine
Purity: ≥98%
Packaging: 500mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 21039
Product name: 2'-O-Methylguanosine
Purity: ≥98%
Packaging: 1g
Price: $153
Updated: 2024/03/01

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2'-O-Methylguanosine Chemical Properties,Usage,Production

Description

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.

Physiological effects

2'-O-Methylguanosine is a modified nucleoside, it is thought to stabilize the structure of the tRNA.2'-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2'-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

References

[1] B C PERSSON C G G J?ger. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2’-O-methyltransferase activity.[J]. Nucleic Acids Research, 1997, 25 20: 4093-4097. DOI: 10.1093/nar/25.20.4093
[2] RYOTA YAMAGAMI. Folate-/FAD-dependent tRNA methyltransferase from Thermus thermophilus regulates other modifications in tRNA at low temperatures[J]. Genes to Cells, 2016, 21 7: 740-754. DOI: 10.1111/gtc.12376
[3] JAUNIUS URBONAVICIUS Glenn R B Jér?me M B Durand. Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri.[J]. Journal of Bacteriology, 2002, 184 19: 5348-5357. DOI: 10.1128/jb.184.19.5348-5357.2002
[4] MIROS?AWA Z. BARCISZEWSKA Jan B Tamara D Mashkova. The primary structure of lupin seed 5.8 S ribosomal RNA[J]. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990, 1049 3: Pages 343-345. DOI: 10.1016/0167-4781(90)90108-e
[5] K SIRUM-CONNOLLY T L M. The role of nucleotide modifications in the yeast mitochondrial ribosome.[J]. Nucleic acids symposium series, 1995, 33: 73-75.
[6] TSUNEATSU MORI . Isolation and Identification of Apoptosis Inducing Nucleosides from CD57+HLA-DRbrightNatural Suppressor Cell Line[J]. Biochemical and biophysical research communications, 1998, 251 2: Pages 416-422. DOI: 10.1006/bbrc.1998.9423

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-Methylguanosine Suppliers

Americas 1 Canada 2 China 246 Europe 1 Germany 2 India 8 Japan 1 Poland 1 Slovakia 1 South Korea 1 United Kingdom 6 United States 22 Global 292

HeFei ShenShen Medical Technology Co.,Ltd

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View Lastest Price from 2'-O-Methylguanosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: 2'-O-Methylguanosine 2140-71-8
Price: US $99.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 1000KG
Release date: 2025-10-10

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 2'-O-Methylguanosine 2140-71-8
Price: US $0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-05-10

Yunbio Tech Co.,Ltd.

Product: 2'-O-Methylguanosine 2140-71-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 300KG per month
Release date: 2023-03-04

2140-71-8, 2'-O-MethylguanosineRelated Search:

Methyl hesperidin Guanosine Guanosine 5'-monophosphate disodium salt Acyclovir 7,8-Dihydro-7-methylguanosine 5'-Guanylic acid 2',3'-O-Isopropylideneguanosine 2',3',5'-Triacetylguanosine 1-METHYLGUANOSINE N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N2-Isobutyryl-2'-O-Methyl-guanosine 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine 2-Methylguanosine,N2-METHYLGUANOSINE,N-Methylguanosine N2-dimethylformamidine-2'-O-Methyl-guanosine 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine 2'-C-Methylguanosine 2'-O-Methylguanosine 2'-(N-Methylanthraniloyl)guanosine 3',5'-Cyclicmonophosphate, Sodium Salt

2'-OMe-G

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one

2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one

2'-OMe Guanosine

2'-O-Methyl-D-guanosine

2'-O-Methyl Guanosine, >=99%

2-aMino-9-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one

2'-O-Methylguanosine Hydrate

2'-OMe-Gr

2'-O-MethylguanosineHydrate&gt

Guanosine, 2'-O-methyl-

2'-OMe-rG

2'-O-Methylguanosine USP/EP/BP

2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

2’-O-Methylguanosine,RNA modified nucleoside Gm

Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA

2 '- Methoxyguanosine

2'-O-Methylguanosine

2'- 0 -Methylguanosine

OMe-rG

2’-OMe-Guanosine, 10 mM in DMSO

2&#8242,-O-Me-Guo

2'-O-Methylguanosine

2'-O-Methylguanosine - [X72830]

2140-71-8

C11H15N5O5xH2O

C11H15N5O5H2O

Nucleotides

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleosides

Modified（deoxy）nucleoside

Nucleosides-2'-OMe Nucleosides