2'-O-Methylguanosine

Product Name: 2'-O-Methylguanosine
CAS No.: 2140-71-8
Chemical Name: 2'-O-Methylguanosine
Synonyms: 2'-OMe-G;2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe-Gr;2'-OMe Guanosine;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methylguanosine;2 '- Methoxyguanosine
CBNumber: CB2276641
Molecular Formula: C11H15N5O5
Formula Weight: 297.27
MOL File: 2140-71-8.mol

More

Less

2'-O-Methylguanosine Property

Melting point:: 227-231°C (dec.)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Aqueous Base (Slightly), DMSO (Slightly),
pka: 9?+-.0.20(Predicted)
form: Powder
color: White to Off-white
λmax: 256 (pH 1)；258 (pH 11)
InChI: InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey: OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES: OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference: 2140-71-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-22
Safety Statements: 26-36-60-36/37
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: M2318
Product name: 2'-O-Methylguanosine Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $280
Updated: 2024/03/01

TCI Chemical

Product number: M2318
Product name: 2'-O-Methylguanosine Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $89
Updated: 2024/03/01

Alfa Aesar

Product number: J65770
Product name: 2'-O-Methylguanosine, 99%
Packaging: 1g
Price: $82.4
Updated: 2024/03/01

Alfa Aesar

Product number: J65770
Product name: 2'-O-Methylguanosine
Purity: 99%
Packaging: 250mg
Price: $20.2
Updated: 2021/12/16

Cayman Chemical

Product number: 21039
Product name: 2'-O-Methylguanosine
Purity: ≥98%
Packaging: 250mg
Price: $57
Updated: 2024/03/01

More

Less

2'-O-Methylguanosine Chemical Properties,Usage,Production

Description

2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2'-O-Methylguanosine Suppliers

Americas 1 Canada 2 China 210 Europe 1 Germany 2 India 8 Japan 1 Poland 1 Slovakia 1 South Korea 1 United Kingdom 6 United States 22 Global 256

MDP ChemControl Ltd.

Tel: --
Fax: --
Email: chemcontrol@nextra.sk
Country: Slovakia
ProdList: 6700
Advantage: 60

More

Less

View Lastest Price from 2'-O-Methylguanosine manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 2'-O-Methylguanosine 2140-71-8
Price: US $0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-05-10

Yunbio Tech Co.,Ltd.

Product: 2'-O-Methylguanosine 2140-71-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 300KG per month
Release date: 2023-03-04

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: 2'-O-Methylguanosine 2140-71-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-12-27

2140-71-8, 2'-O-MethylguanosineRelated Search:

5'-Guanylic acid Methyl hesperidin Guanosine Guanosine 5'-monophosphate disodium salt Acyclovir 7,8-Dihydro-7-methylguanosine 2',3'-O-Isopropylideneguanosine 2',3',5'-Triacetylguanosine 1-METHYLGUANOSINE N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N2-Isobutyryl-2'-O-Methyl-guanosine 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine 2-Methylguanosine,N2-METHYLGUANOSINE,N-Methylguanosine N2-dimethylformamidine-2'-O-Methyl-guanosine 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine 2'-C-Methylguanosine 2'-(N-Methylanthraniloyl)guanosine 3',5'-Cyclicmonophosphate, Sodium Salt 2',3',5-TRI-O-ACETYL-8-BROMOGUANOSINE

2'-OMe-G

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one

2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one

2'-OMe Guanosine

2'-O-METHYLGUANOSINE

2'-O-Methyl-D-guanosine

2'-O-Methyl Guanosine, >=99%

2-aMino-9-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one

2'-O-Methylguanosine Hydrate

2'-OMe-Gr

2'-O-MethylguanosineHydrate&gt

Guanosine, 2'-O-methyl-

2'-OMe-rG

2'-O-Methylguanosine USP/EP/BP

2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

2’-O-Methylguanosine,RNA modified nucleoside Gm

Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA

2 '- Methoxyguanosine

2'-O-Methylguanosine

2'-OMe Guanosine

2'-OMe-G

2'-OMe-Gr

2'- 0 -Methylguanosine

2140-71-8

C11H15N5O5xH2O

C11H15N5O5H2O

Nucleotides

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleosides

Modified（deoxy）nucleoside

Nucleosides-2'-OMe Nucleosides