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2'-O-Methylguanosine

Product Name
2'-O-Methylguanosine
CAS No.
2140-71-8
Chemical Name
2'-O-Methylguanosine
Synonyms
2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe Guanosine;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methylguanosine;2 '- Methoxyguanosine;2'-O-Methyl-D-guanosine;Guanosine, 2'-O-methyl-
CBNumber
CB2276641
Molecular Formula
C11H15N5O5
Formula Weight
297.27
MOL File
2140-71-8.mol
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2'-O-Methylguanosine Property

Melting point:
227-231°C (dec.)
Density 
1.98±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Aqueous Base (Slightly), DMSO (Slightly),
pka
9?+-.0.20(Predicted)
form 
Powder
color 
White to Off-white
InChI
InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey
OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES
OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference
2140-71-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-22
Safety Statements 
26-36-60-36/37
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2318
Product name
2'-O-Methylguanosine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$280
Updated
2024/03/01
TCI Chemical
Product number
M2318
Product name
2'-O-Methylguanosine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
J65770
Product name
2'-O-Methylguanosine, 99%
Packaging
1g
Price
$82.4
Updated
2024/03/01
Alfa Aesar
Product number
J65770
Product name
2'-O-Methylguanosine
Purity
99%
Packaging
250mg
Price
$20.2
Updated
2021/12/16
Cayman Chemical
Product number
21039
Product name
2'-O-Methylguanosine
Purity
≥98%
Packaging
250mg
Price
$57
Updated
2024/03/01
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2'-O-Methylguanosine Chemical Properties,Usage,Production

Description

2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-Methylguanosine Suppliers

Americas 1 Canada 2 China 192 Europe 1 Germany 2 India 8 Japan 1 Poland 1 Slovakia 1 South Korea 1 United Kingdom 6 United States 21 Global 237
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23662
Advantage
75
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View Lastest Price from 2'-O-Methylguanosine manufacturers

Yunbio Tech Co.,Ltd.
Product
2'-O-Methylguanosine 2140-71-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
300KG per month
Release date
2023-03-04
Hefei Huana Biomedical Technology Co.,Ltd.
Product
2'-O-Methylguanosine 2140-71-8
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
100kg
Release date
2023-05-10
Zhejiang Hengkang Pharmaceutical Co., Ltd.
Product
2'-O-Methylguanosine 2140-71-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg per month
Release date
2022-12-27

2140-71-8, 2'-O-MethylguanosineRelated Search:

5'-Guanylic acid Methyl hesperidin Guanosine Guanosine 5'-monophosphate disodium salt Acyclovir 7,8-Dihydro-7-methylguanosine 2',3'-O-Isopropylideneguanosine 2',3',5'-Triacetylguanosine 1-METHYLGUANOSINE N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N2-Isobutyryl-2'-O-Methyl-guanosine 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine 2-Methylguanosine,N2-METHYLGUANOSINE,N-Methylguanosine N2-dimethylformamidine-2'-O-Methyl-guanosine 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine 2'-C-Methylguanosine 2'-(N-Methylanthraniloyl)guanosine 3',5'-Cyclicmonophosphate, Sodium Salt 2',3',5-TRI-O-ACETYL-8-BROMOGUANOSINE

  • 2'-OMe-G
  • 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one
  • 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one
  • 2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one
  • 2'-OMe Guanosine
  • 2'-O-METHYLGUANOSINE
  • 2'-O-Methyl-D-guanosine
  • 2'-O-Methyl Guanosine, >=99%
  • 2-aMino-9-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one
  • 2'-O-Methylguanosine Hydrate
  • 2'-OMe-Gr
  • 2'-O-MethylguanosineHydrate&gt
  • Guanosine, 2'-O-methyl-
  • 2'-OMe-rG
  • 2'-O-Methylguanosine USP/EP/BP
  • 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one
  • 2’-O-Methylguanosine,RNA modified nucleoside Gm
  • Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA
  • 2 '- Methoxyguanosine
  • 2'-O-Methylguanosine
  • 2'-OMe Guanosine
  • 2140-71-8
  • C11H15N5O5xH2O
  • C11H15N5O5H2O
  • Nucleotides
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleosides
  • Modified（deoxy）nucleoside