ChemicalBook > CAS DataBase List > 7-BROMO-2-CHLORO-QUINOLINE

7-BROMO-2-CHLORO-QUINOLINE

Product Name: 7-BROMO-2-CHLORO-QUINOLINE
CAS No.: 99455-15-9
Chemical Name: 7-BROMO-2-CHLORO-QUINOLINE
Synonyms: 7-BROMO-2-CHLORO-QUINOLINE;Quinoline, 7-bromo-2-chloro-
CBNumber: CB8713528
Molecular Formula: C9H5BrClN
Formula Weight: 242.5
MOL File: 99455-15-9.mol

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7-BROMO-2-CHLORO-QUINOLINE Property

Melting point:: 120-121 °C
Boiling point:: 325.7±22.0 °C(Predicted)
Density: 1.673±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: -1.25±0.50(Predicted)
color: Pale yellow
InChI: InChI=1S/C9H5BrClN/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5H
InChIKey: MOEWRAKNXMILKB-UHFFFAOYSA-N
SMILES: N1C2C(=CC=C(Br)C=2)C=CC=1Cl

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-41
Safety Statements: 26-39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000071
Product name: 7-Bromo-2-chloroquinoline
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B682808
Product name: 7-Bromo-2-chloro-quinoline
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B682808
Product name: 7-Bromo-2-chloro-quinoline
Packaging: 1g
Price: $130
Updated: 2021/12/16

TRC

Product number: B682808
Product name: 7-Bromo-2-chloro-quinoline
Packaging: 2.5g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: OR3654
Product name: 7-Bromo-2-chloroquinoline
Purity: 97%
Packaging: 1g
Price: $127
Updated: 2021/12/16

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7-BROMO-2-CHLORO-QUINOLINE Chemical Properties,Usage,Production

Synthesis

99465-10-8

99455-15-9

General procedure for the synthesis of 7-bromo-2-chloroquinoline from 7-bromoquinolin-2(1H)-one: To an inert reactor equipped with a mechanical stirrer, a reflux condenser, a charging funnel and a caustic scrubber were added 7-bromo-2-hydroxyquinoline (1.22 kg, 5.45 mol), dichloromethane (9.706 kg) and dimethylformamide (0.276 kg). Thionyl chloride (0.973 kg, 8.17 mol, 1.5 eq.) was added slowly and dropwise. The reaction mixture was gradually heated to reflux and kept at reflux until the reaction was complete (about 2 hours). After completion of the reaction, the mixture was cooled to 20-25 °C, USP grade purified water (3.663 kg) was added and stirred. Subsequently, a solution of potassium carbonate (0.828 kg) dissolved in USP grade purified water (0.828 kg) was slowly added with stirring. Stirring was stopped after 15 minutes and left to stratify. After confirming that the pH of the aqueous layer was greater than 7, the dichloromethane layer was separated and washed with USP grade purified water (3.663 kg). USP grade purified water (7.326 kg) was added to the dichloromethane solution and the dichloromethane was removed by distillation until the product precipitated from the aqueous layer. The reactor was cooled to 20-25 °C, the product was collected by filtration and washed with USP grade purified water (2 x 1.22 kg). The product was dried in a vacuum oven at 40-50 °C to give the final 7-bromo-2-chloroquinoline (1.154 kg, 78.8% yield). The product was analyzed by NMR and the results were consistent with the expected structure.

References

[1] Patent: WO2009/2955, 2008, A1. Location in patent: Page/Page column 10
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 16, p. 5836 - 5857

7-BROMO-2-CHLORO-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-BROMO-2-CHLORO-QUINOLINE manufacturers

Career Henan Chemical Co

Product: 7-BROMO-2-CHLORO-QUINOLINE 99455-15-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

99455-15-9, 7-BROMO-2-CHLORO-QUINOLINERelated Search:

7-bromo-2-chloroquinazolin-4-amine 7-bromo-2-chloroquinazoline 7-Bromo-2-chloroquinoxaline 7-Bromo-2-chloro-3-ethylquinoline 6-BROMO-4-CHLORO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER 6-BROMO-2-CHLORO-QUINOLINE 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE 7-BROMO-2-CHLORO-QUINOLINE-3-CARBALDEHYDE 7-BROMO-2-CHLOROQUINOLINE-3-METHANOL 7-BROMO-2-CHLORO-QUINOLINE 7-BROMO-2-CHLORO-3-PHENYLQUINOLINE 7-BROMO-2-CHLOROQUINOLINE-3-CARBONITRILE 7-BROMO-2-CHLORO-3-METHYLQUINOLINE 6-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID 6-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 8-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 7-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE

Quinoline, 7-bromo-2-chloro-

7-BROMO-2-CHLORO-QUINOLINE

99455-15-9