ChemicalBook > CAS DataBase List > Emedastine

Emedastine

Product Name: Emedastine
CAS No.: 87233-61-2
Chemical Name: Emedastine
Synonyms: Emestine;EMEDASTINE;Emedastine impurity F;Emedastinc Impurity C;Emedastine Impurity C;Emedastine Impurity 14;Emedastine, 10 mM in DMSO;1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole;1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole;1-(2-ethoxyethyl)-2-(4-Methyl-1,4-diazepan-1-yl)-1H-1,3-benzodiazole
CBNumber: CB8728076
Molecular Formula: C17H26N4O
Formula Weight: 302.41
MOL File: 87233-61-2.mol

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Emedastine Property

Boiling point:: 446.6±55.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 125 mg/mL (413.35 mM); Ethanol: 100 mg/mL (330.68 mM)
pka: 8.86±0.10(Predicted)
form: Viscous Liquid
color: Yellow to brown
CAS DataBase Reference: 87233-61-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028590
Product name: Emedastine
Purity: ≥98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009136
Product name: EMEDASTINE
Purity: 95.00%
Packaging: 5MG
Price: $496.67
Updated: 2021/12/16

ChemScene

Product number: CS-0028590
Product name: Emedastine
Purity: ≥98.0%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0028590
Product name: Emedastine
Purity: ≥98.0%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0028590
Product name: Emedastine
Purity: ≥98.0%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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Emedastine Chemical Properties,Usage,Production

Uses

Antihistaminic, H1-receptor; asthma prophylactic; anti-allergic.

Definition

ChEBI: 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the ifumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.

brand name

Emadine (Alcon).

Clinical Use

Emedastine also is a newer antihistamine used topically in the eye for conjunctivitis. It has very high H1 receptor selectivity characteristics, and it is structurally related to the benzimidazoles, such as astemizole. Inhibition of mast cell release of inflammatory mediators has been noted.

in vivo

Emedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg^[3].
Pretreatment with Emedastine (0.03, 0.1, 0.3 mg/kg; orally) significantly inhibits the scratching induced by substance P and leukotriene B^[3].
Emedastine (0.3 mg/kg, p.o.) produces significant inhibition of passive peritoneal anaphylaxis in guinea-pigs^[2].
Emedastine inhibits histamine-induced contractions of isolated ileum (IC₅₀=6.1 nM)^[2].

Animal Model:	Male ICR mice 5-6 weeks of age^[3]
Dosage:	0.03, 0.1, 0.3 mg/kg
Administration:	Orally; 30 min before pruritogen injection
Result:	Significantly suppressed histamine-induced scratching with pretreatment of 0.1 and 0.3 mg/kg.

IC 50

H₁ Receptor: 1.3 nM (Ki); H₂ Receptor: 49067 nM (Ki); H₃ Receptor: 12430 nM (Ki)

Emedastine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Emedastine manufacturers

Career Henan Chemical Co

Product: Emedastine 87233-61-2
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-14

87233-61-2, EmedastineRelated Search:

METSULFURON METHYL Heptane Betahistine ULINASTATIN Ibudilast Methyl salicylate Tribenuron methyl Basic Violet 1 Methyl acrylate Benzimidazole Methylparaben Cilastatin Phenformin Imipenem-Cilastatin sodium hydrate Kresoxim-methyl Methanol Sodium 1-heptanesulfonate Methyl

EMEDASTINE

1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole

1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepine-1-yl)-1H-benzimidazole

1-(2-Ethoxyethyl)-2-[(hexahydro-4-methyl-1H-1,4-diazepin)-1-yl]-1H-benzimidazole

1-(2-ethoxyethyl)-2-(4-Methyl-1,4-diazepan-1-yl)-1H-1,3-benzodiazole

1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole

1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole

Emedastine impurity F

allergic,Histamine Receptor,antiallergic,benzimidazole,Inhibitor,skin,inhibit,Emedastine,orally,rhinitis,diseases,conjunctivitis

Emedastine Impurity 14

Emedastine Impurity C

Emestine

Emedastinc Impurity C

Emedastine, 10 mM in DMSO

87233-61-2

C17H26N4O

impurity

DCP

GYL