Emedastine
- Product Name
- Emedastine
- CAS No.
- 87233-61-2
- Chemical Name
- Emedastine
- Synonyms
- Emestine;EMEDASTINE;Emedastine impurity F;Emedastinc Impurity C;Emedastine Impurity C;Emedastine Impurity 14;Emedastine, 10 mM in DMSO;1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole;1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole;1-(2-ethoxyethyl)-2-(4-Methyl-1,4-diazepan-1-yl)-1H-1,3-benzodiazole
- CBNumber
- CB8728076
- Molecular Formula
- C17H26N4O
- Formula Weight
- 302.41
- MOL File
- 87233-61-2.mol
Emedastine Property
- Boiling point:
- 446.6±55.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 125 mg/mL (413.35 mM); Ethanol: 100 mg/mL (330.68 mM)
- pka
- 8.86±0.10(Predicted)
- form
- Viscous Liquid
- color
- Yellow to brown
- CAS DataBase Reference
- 87233-61-2(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- CS-0028590
- Product name
- Emedastine
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- API0009136
- Product name
- EMEDASTINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.67
- Updated
- 2021/12/16
- Product number
- CS-0028590
- Product name
- Emedastine
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0028590
- Product name
- Emedastine
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0028590
- Product name
- Emedastine
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
Emedastine Chemical Properties,Usage,Production
Uses
Antihistaminic, H1-receptor; asthma prophylactic; anti-allergic.
Definition
ChEBI: 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the ifumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.
brand name
Emadine (Alcon).
Clinical Use
Emedastine also is a newer antihistamine used topically in the eye for conjunctivitis. It has very high H1 receptor selectivity characteristics, and it is structurally related to the benzimidazoles, such as astemizole. Inhibition of mast cell release of inflammatory mediators has been noted.
in vivo
Emedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg[3].
Pretreatment with Emedastine (0.03, 0.1, 0.3 mg/kg; orally) significantly inhibits the scratching induced by substance P and leukotriene B[3].
Emedastine (0.3 mg/kg, p.o.) produces significant inhibition of passive peritoneal anaphylaxis in guinea-pigs[2].
Emedastine inhibits histamine-induced contractions of isolated ileum (IC50=6.1 nM)[2].
| Animal Model: | Male ICR mice 5-6 weeks of age[3] |
| Dosage: | 0.03, 0.1, 0.3 mg/kg |
| Administration: | Orally; 30 min before pruritogen injection |
| Result: | Significantly suppressed histamine-induced scratching with pretreatment of 0.1 and 0.3 mg/kg. |
IC 50
H1 Receptor: 1.3 nM (Ki); H2 Receptor: 49067 nM (Ki); H3 Receptor: 12430 nM (Ki)
Emedastine Preparation Products And Raw materials
Raw materials
Preparation Products
Emedastine Suppliers
- Tel
- --
- Fax
- --
- sales@alsachim.com
- Country
- France
- ProdList
- 424
- Advantage
- 0
View Lastest Price from Emedastine manufacturers
- Product
- Emedastine 87233-61-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-14