ChemicalBook > CAS DataBase List > 4-HYDROXY-3-NITROPHENYLACETIC ACID

4-HYDROXY-3-NITROPHENYLACETIC ACID

Product Name: 4-HYDROXY-3-NITROPHENYLACETIC ACID
CAS No.: 10463-20-4
Chemical Name: 4-HYDROXY-3-NITROPHENYLACETIC ACID
Synonyms: TIMTEC-BB SBB007785;3-NITRO-4-HYDROXYPHENYLACETIC ACID;4-HYDROXY-3-NITROPHENYLACETIC ACID;4-Hydroxy-3-nitrobenzeneacetic acid;4-Hydroxy-3-nitrophenylaceticAcid>Benzeneacetic acid, 4-hydroxy-3-nitro-;2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID;4-Hydroxy-3-nitrophenylacetic acid,99%;4-Hydroxy-3-nitrophenylacetic acid 98%;4-Hydroxy-3-nitrophenylacetic acid, 10 mM in DMSO
CBNumber: CB8737517
Molecular Formula: C8H7NO5
Formula Weight: 197.14
MOL File: 10463-20-4.mol

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4-HYDROXY-3-NITROPHENYLACETIC ACID Property

Melting point:: 146-148 °C (lit.)
Boiling point:: 334.23°C (rough estimate)
Density: 1.5023 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: ethanol: soluble5%, clear, yellow to orange
form: crystalline
pka: 4.25±0.10(Predicted)
color: yellow
BRN: 2696044
CAS DataBase Reference: 10463-20-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: T
HazardClass: IRRITANT
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219924
Product name: 4-Hydroxy-3-nitrophenylacetic acid
Purity: 99%
Packaging: 1g
Price: $50.25
Updated: 2025/07/31

TCI Chemical

Product number: H1362
Product name: 4-Hydroxy-3-nitrophenylacetic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: H1362
Product name: 4-Hydroxy-3-nitrophenylacetic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $151
Updated: 2025/07/31

Usbiological

Product number: 279309
Product name: 4-Hydroxy-3-nitrophenylacetic acid
Packaging: 50mg
Price: $425
Updated: 2021/12/16

TRC

Product number: H948685
Product name: 4-Hydroxy-3-nitrophenylacetic Acid
Packaging: 1g
Price: $105
Updated: 2021/12/16

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4-HYDROXY-3-NITROPHENYLACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

4-Hydroxy-3-nitrophenylacetic acid was used in the synthesis of 4-hydroxy-3-nitrophenylacetyl caproic acid.

Uses

A metabolite of Nitrotyrosine (N597000), which is excreted in the urine.

Definition

ChEBI: (4-hydroxy-3-nitrophenyl)acetic acid is a monocarboxylic acid that is acetic acid carrying a 2-hydroxy-3-nitrophenyl substituent at C-2. It has a role as a hapten. It is a conjugate acid of a (4-hydroxy-3-nitrophenyl)acetate.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 1166, 1987 DOI: 10.1021/jm00390a009

General Description

4-Hydroxy-3-nitrophenylacetic acid enhances the ice-nucleation activity of Xanthomonas campestris.

Synthesis

156-38-7

10463-20-4

General procedure for the synthesis of 4-hydroxy-3-nitrophenylacetic acid from p-hydroxyphenylacetic acid: (a) Nitration reaction: fuming nitric acid (1.36 mL) was slowly added dropwise to a solution of 4-hydroxyphenylacetic acid (4.00 g, 26.3 mmol) in acetic acid (25 mL) under cooling in an ice bath. After the dropwise addition was completed, the reaction mixture was slowly warmed up to room temperature and reacted for 1 hour, during which time the solution gradually changed from yellow to brown color, accompanied by the formation of a precipitate. After completion of the reaction, the solid product was collected by filtration and recrystallized from ethyl acetate/hexane mixed solvent to obtain yellow needle-like crystals of 4-hydroxy-3-nitrophenylacetic acid (3.61 g, 70% yield). The structure of the product was confirmed by 1H-NMR: δ (CDCl3-d4/DMSO, 4:1) 3.50 (2H, s), 7.04 (1H, d, J = 9 Hz), 7.46 (1H, dd, J = 9, 3 Hz), 7.94 (1H, d, J = 3 Hz).

References

[1] Synthetic Communications, 1985, vol. 15, # 12, p. 1075 - 1080
[2] Patent: US5229510, 1993, A
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 7, p. 1166 - 1176
[4] Patent: US9995679, 2018, B2. Location in patent: Page/Page column 52
[5] Patent: US5852191, 1998, A

4-HYDROXY-3-NITROPHENYLACETIC ACID Preparation Products And Raw materials

Raw materials

Ethanol 4-Hydroxybenzyl cyanide Potassium hydroxide Ethyl acetate Nitric acid Acetic acid PETROLEUM ETHER Sulfuric acid

Preparation Products

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4-HYDROXY-3-NITROPHENYLACETIC ACID Suppliers

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View Lastest Price from 4-HYDROXY-3-NITROPHENYLACETIC ACID manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 2-(4-hydroxy-3-nitrophenyl)acetic acid 10463-20-4
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-05-12

Henan Fengda Chemical Co., Ltd

Product: 4-HYDROXY-3-NITROPHENYLACETIC ACID 10463-20-4
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Hydroxy-3-nitrophenylacetic acid 10463-20-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2020-01-10

10463-20-4, 4-HYDROXY-3-NITROPHENYLACETIC ACIDRelated Search:

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4-Hydroxy-3-nitrophenylacetic acid 98%

3-NITRO-4-HYDROXYPHENYLACETIC ACID

4-Hydroxy-3-nitrobenzeneacetic acid

4-Hydroxy-3-nitrophenylacetic acid,99%

2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID

4-HYDROXY-3-NITROPHENYLACETIC ACID

Benzeneacetic acid, 4-hydroxy-3-nitro-

TIMTEC-BB SBB007785

4-Hydroxy-3-nitrophenylaceticAcid&gt

4-HYDROXY-3-NITROPHENYLACETIC ACID ISO 9001：2015 REACH

4-Hydroxy-3-nitrophenylacetic acid, 10 mM in DMSO

10463-20-4

HOC6H3NO2CH2CO2H

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Aromatics

Metabolites & Impurities

Carbonyl Compounds

Carboxylic Acids

Phenyls & Phenyl-Het

Carboxylic Acids

Phenyls & Phenyl-Het

Aromatics, Metabolites & Impurities

Aromatic Phenylacetic Acids and Derivatives