Hederagenin

Product Name: Hederagenin
CAS No.: 465-99-6
Chemical Name: Hederagenin
Synonyms: Hederidin;NSC 24954;hederagenol;HEDERAGENIN;Hederogenin;Rangefinder;Hederagenine;MELANTHIGENIN;Vaccaric acid;Kalosapogenin
CBNumber: CB8739586
Molecular Formula: C30H48O4
Formula Weight: 472.71
MOL File: 465-99-6.mol

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Hederagenin Property

Melting point:: 332-334°
alpha: D20 +81° (c = 0.7 in pyridine)
Boiling point:: 493.44°C (rough estimate)
Density: 0.9871 (rough estimate)
refractive index: 1.4800 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: methanol: soluble1mg/mL
pka: 4.63±0.70(Predicted)
form: Solid
color: White to Off-White
λmax: 405nm(H2SO4)(lit.)
Merck: 14,4624
InChIKey: PGOYMURMZNDHNS-MYPRUECHSA-N
LogP: 7.410 (est)

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Safety

Hazard Codes: Xi
Risk Statements: 22
Safety Statements: 22-45-24/25
WGK Germany: 3
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H3916
Product name: Hederagenin
Purity: ≥97% (HPLC)
Packaging: 10mg
Price: $477
Updated: 2024/03/01

TCI Chemical

Product number: H1645
Product name: Hederagenin
Purity: >98.0%(HPLC)(T)
Packaging: 50mg
Price: $164
Updated: 2024/03/01

TCI Chemical

Product number: H1645
Product name: Hederagenin
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $565
Updated: 2024/03/01

Cayman Chemical

Product number: 27030
Product name: Hederagenin
Packaging: 250mg
Price: $629
Updated: 2024/03/01

Cayman Chemical

Product number: 27030
Product name: Hederagenin
Packaging: 500mg
Price: $1116
Updated: 2024/03/01

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Hederagenin Chemical Properties,Usage,Production

Description

Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.

Chemical Properties

White Solid

Uses

Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.

Definition

ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).

Hederagenin Preparation Products And Raw materials

Raw materials

Preparation Products

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Hederagenin Suppliers

Americas 1 Canada 2 China 230 Europe 1 France 2 Germany 4 India 2 Japan 1 United Kingdom 6 United States 22 Global 271

Carbosynth

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Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

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Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
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Apin Chemicals Limited (UK)

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Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6184
Advantage: 60

Leancare Ltd.

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Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

MOLEKULA Ltd.

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Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
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Apin Chemicals Ltd.

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Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6807
Advantage: 42

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View Lastest Price from Hederagenin manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Hederagenin 465-99-6
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-03

Shanghai Standard Technology Co., Ltd.

Product: Hederagenin 465-99-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-29

Shanghai Standard Technology Co., Ltd.

Product: Hederagenin 465-99-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-09-29

465-99-6, HederageninRelated Search:

Ginsenoside Rh2 4-Hydroxycinnamic acid Oleanolic acid Folic acid Ethyl 2-(Chlorosulfonyl)acetate Diosgenin Ascoric Acid Phytolaccagenin esculentoside E Bayogenin Escin sodium Ginsenosides CAULOPHYLLOGENIN Tubeimoside A Hederacoside C medicagenic acid Platycodin D ALPHA-HEDERIN

HEDERAGENIN(RG)

(3β,4α) -3,23-Dihydroxy-olean-12-en- 28-oic acid

CAULOSAPOGENIN

HEDERAGENIN

3,23-DIHYDROXYOLEAN-12-EN-28 OIC ACID

(3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid

3,23-dihydroxy-,(3-beta,4-alpha)-olean-12-en-28-oicaci

3-beta,23-dihydroxy-olean-12-en-28-oicaci

astrantiagenine

hederagenicacid

hederagenol

MELANTHIGENIN

Hederagenin 465-99-6

Hederagenin, 98%, from Hedera nepalensisvar.sinensis

CAULOSAPOGENIN hplc

HEDERAGENIN WITH HPLC

(3b,4a)-3,23-Dihydroxyolean-12-en-28-oic acid

(4R)-3β,23-Dihydroxyolean-12-en-28-oic acid

Hederogenin

Vaccaric acid

(4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-methylol-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

(4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

Hederidin

Kalosapogenin

Hederagenine

NSC 24954

3,23-Dihydroxyolean-12-en-28-acid

Hederagenin, >=98%

Olean-12-en-28-oicacid, 3,23-dihydroxy-, (3b,4a)-

(4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylicaci

Rangefinder

(4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-Hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

Olean-12-en-28-oic acid, 3,23-dihydroxy-, (3β,4α)-

Hederagenin(AS)

Hederagenin-RM

465-99-6

14126-03-6

Saponins

Pentacyclic Triterpenes

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Detergent

Intermediates & Fine Chemicals

Pharmaceuticals